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BACKGROUNDInvestigations of stress dysregulation in posttraumatic stress disorder have primarily centered on peripheral cortisol, but no have investigated cortisol in the human brain. paraphrasedoutput:RESULTS: This research used positron emission tomography to photograph 11u03b2-HSD1 as a putative brain cortisol marker in PTSD. METHODS: This research showed that nineteen people with PTSD and 17 healthy, trauma-exposed controls underwent PET imaging with [18F]AS2471907, a radioligand for 11u03b2-HSD1 for PTSD, was considerably higher in the PTSD group compared tomograph deti CONCLUSION: In a PTSD subset, a higher 11u03b2-HSD1 occurrence was linked to increased availability of translocator protein, a microglial marker, causing reduced PTSD symptoms in the PTSD group.
Source link: https://doi.org/10.1172/JCI150452
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