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Cortisol - Springer Nature

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Last Updated: 19 September 2022

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Adrenalectomy improves blood pressure control in nonfunctioning adrenal incidentalomas and glycemic and lipid control in patients with autonomous cortisol secretion

Methods An retrospective review of all patients with NFAI and ACS who were hospitalized or in follow-up in our center between January 2011 and 2020 is published. Patients with ACS at baseline were older than those with NFAI at baseline. Patients with ACS had a greater risk of hypertension and elevated blood glucose and HbA1c after adjusting by age, as well as NFAI. ACS patients who underwent adrenalectomy had a larger decline in glucose levels and triglycerides than ACS patients who conservatively handled. Compared to the conservative group's NFAI, NFAI patients who underwent surgery noticed a decrease in systolic blood pressure relative to the NFAI. Conclusions The benefits of adrenalectomy in the cardiometabolic profile of adrenal incidentalomas are not limited to the group of patients with ACS, but an increase in blood pressure control is also present in NFAI patients after surgery.

Source link: https://doi.org/10.1007/s12020-022-03120-w


Urinary free cortisol excretion is associated with lumbar bone density in patients with adrenal Cushing’s syndrome

The lumbar spine bone mineral density decreases as a result of increased adrenal cortisol overproduction is the most notable lumbar spine bone density decrease. Patients with adrenal Cushing'u2019s syndrome have a poor prognosis as a result of the autonomous hypersecretion of endogenous cortisol from the adrenal gland. After the overnight dexamethasone suppression test, but not the morning or late at night or indices of a regulated tomography were strongly and positively associated with the adrenal cortisol level, was found to be significantly and positively linked to the adrenal cortisol content, the adrenal cortisol level was measured. These findings indicate that 24-h urinary free cortisol excretion is best related to a decrease in bone density as a result of elevated adrenal cortisol overproduction and that it could be used as a marker for osteoporosis in these patients.

Source link: https://doi.org/10.1038/s41440-022-00939-8


Loneliness and diurnal cortisol levels during COVID-19 lockdown: the roles of living situation, relationship status and relationship quality

During the first lockdown in Germany, we investigated living conditions, marital status, and quality as potential moderators for trait and state depression, salivary cortisol levels in healthy adults. Next, N = 247 completed ecological momentary evaluation, collecting twelve saliva samples on two days and reporting their momentary loneliness levels simultaneously. Participants with a spouse and those who were living apart from their partner reported loneliness levels similar to singles living alone, reducing loneliness in participants with a partner and those who were living alone. A significant cross-level relationship between relationship status and momentary loneliness in predicting cortisol predicted cortisol was discovered by hierarchical linear models.

Source link: https://doi.org/10.1038/s41598-022-19224-2


Assessment of DHEAS, cortisol, and DHEAS/cortisol ratio in patients with COVID-19: a pilot study

In sepsis and inflammatory conditions, the purpose of dehydroepiandrosterone sulfate has been reduced. DHEAS and cortisol, DHEAS/cortisol ratio, and their relationship with inflammatory markers in patients with COVID-19 were investigated in the current research. Conclusions When compared to controls, we found reduced DHEAS and DHEAS/cortisol ratios in cases and higher levels of cortisol in these cases. Conclusions DHEAS levels and DHEAS/cortisol ratio in COVID-19 patients and control subjects are the first of its kind.

Source link: https://doi.org/10.1007/s42000-022-00382-x


Opioid-blunted cortisol response to stress is associated with increased negative mood and wanting of social reward

However, the neurochemistry of stress-related social contact seeking in humans is also unclear. Following a standard psychosocial stress induction, participants in a social reward project, in which the motivation to get skin-to-skin social contact and the hedonic reactions evoked by such touch were assessed. Morphine prevented the rise in salivary cortisol normally observed after acute stress exposure. These findings reveal new insight into the effects of exogenous opioids administration on psychosocial stress's responses, as well as a state-based regulation of social motivations.

Source link: https://doi.org/10.1038/s41386-022-01283-8


Impact of a Mindfulness-Based Stress Reduction Program on Psychological Well-Being, Cortisol, and Inflammation in Women Veterans

Background: Women veterans of combat suffer higher rates of stress-related illnesses than those in civilian populations. Mindfulness-based stress reduction has been shown to increase psychological stability in other populations, but no randomized controlled trials have been conducted to determine the effect of MBSR on well-being and inflammation in women veterans at risk of CVD. Intervention An 8-week MBSR program with weekly 2. 5-h classes was compared to an ACC that consisted of an 8-week health promotion education curriculum with weekly 2. 5-h classes. Participants in the MBSR program reported a more rapid decline in diurnal salivary cortisol as compared to those in the ACC, although there were no significant differences between groups or changes over time. Women veterans with MBSR can be used by health care professionals to increase their psychological stability as a way to improve their psychological stability.

Source link: https://doi.org/10.1007/s11606-022-07584-4


Quantification of cortisol and its metabolites in human urine by LC-MS^n: applications in clinical diagnosis and anti-doping control

The purpose of the current study was to produce a liquid chromatography-MSn system for the determination of free cortisol and its 15 endogenous metabolites in human urine. For the spectrometric analysis, a linear ion trap operating in ESI negative ion mode was chosen for the spectrometric analysis, performing MS3 and MS4 experiments. It was also successful in urine samples of two patients with Cushing syndrome and one with Addison's disease. This experimental strategy could be more dependable than the traditional method of determining urinary free cortisol collected in 24-h urine. The possibility of investigating the differences and relationship between cortisol and its metabolites allows for analytical difficulties related to cortisol alone's quantitative analysis. Moreover, the hypothalamus-hypophysis axis has been shown to be a good antidoping device concerning the potential misuse of corticosteroids, which could interfere with cortisol metabolism, has been shown to be safe for antidoping oversight regarding cortisol metabolism.

Source link: https://doi.org/10.1007/s00216-022-04249-3


Sex and drug differences in stress, craving and cortisol response to the trier social stress task

Following a laboratory stress intervention, there hasn't been a direct comparison of HPA axis and subjective responses between people with different types of drug use disorders. Objectives The current report sought to compare subjective and neuroendocrine responses to the Trier Social Stress Task in various key areas of substance use disorders and examine gender differences between males and females in the Trier Social Stress Task. As compared to other drug use groups, the study groups involving individuals with cocaine use disorder had lessened anxiety, appetite, and cortisol responses after the TSST. Females in the cocaine groups said elevated subjective distress but lower cortisol than males, but not lower cortisol. Conclusions The study found that substances on the HPA axis may have divergent results, with cocaine users leading to more blunting of the HPA axis response than to those using other drugs.

Source link: https://doi.org/10.1007/s00213-022-06163-z


Increases in Circulating Cortisol during the COVID-19 Pandemic are Associated with Changes in Perceived Positive and Negative Affect among Adolescents

The Coronavirus Disease 2019 pandemic has swarmed around the world, resulting in more than 5 million deaths to date, as well as many lockdowns, disruptions of daily life, and an extended period of social alienation and loneliness. According to studies, mental stability among youth has greatly suffered as a result of the pandemic. Corretisol is a stress hormone that rises during chronic conditions and can have deleterious effects on mental and physical wellbeing when elevated. During the pandemic's first wave, there were hair cortisol concentration studies, which allowed retrospectiveinvestigation of circulating cortisol before and after pandemic-related local lockdowns in the first wave. Between May and June of 2020, a final sample of 44 youth ages 10-to-old collected hair samples and reported on their perceived wellbeing and level of anxiety regarding pandemic-related stressors.

Source link: https://doi.org/10.1007/s10802-022-00967-5


Hair cortisol level might be indicative for a 3PM approach towards suicide risk assessment in depression: comparative analysis of mentally stable and depressed individuals versus individuals after completing suicide

Prior studies found elevated levels of cortisol in depressed people's scalp hair, but estimates on suicide completeers are missing. To establish the usage of HCL as a new target for 3 p. m. , we sought to identify differences in HCL between subject with depression, SC, and mentally stable control subjects. An average rise in HCL for depressed patients and SC is seen in 3-cm hair segments, which is not comparable to that for controls. The presence of a significant relationship between HCL in the 1-cm and the 3-cm hair segments, as well as a strong correlation between the severity of depressive symptoms and HCL was discovered. To conclude, the results of elevated HCL in patients with depression compared to that in controls were replicated, and an additional rise in HCL was seen in SC in comparison to patients with depression.

Source link: https://doi.org/10.1007/s13167-022-00296-z

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions