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Those affected individuals can stretch marks on their thighs and abdomen, as well as bruise easily. Individuals with Cushing disease may have a hump on their upper back caused by abnormal fat deposits. Cushing disease may cause mood disorders such as anxiety, exhaustion, and depression. People with Cushing disease have an elevated risk of experiencing elevated blood pressure and diabetes. Women with Cushing disease may have irregular menstruation and excessive hair growth on their face, abdomen, and legs. Erectile dysfunction can occur among men with Cushing disease. Children with Cushing disease have a slow growth rate.
Multiple lumps in the adrenal glands, which are small hormone-producing glands on the roof of each kidney, are a characteristic of primary macronodular hyperplasia. These nodules, which often are found in both adrenal glands and differ in size, cause adrenal gland growth and result in the production of higher-than-normal amounts of the hormone cortisol. However, some people with PMAH do not have these signs and symptoms, and are thought to have subsided Cushing syndrome.
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