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Cortisol - Europe PMC

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Last Updated: 19 September 2022

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Real-time racial discrimination, affective states, salivary cortisol and alpha-amylase in Black adults.

Perception of racial discrimination has been attributed to the autonomic nervous system and hypothalamic-adrenal axis' operation-two major stress response frameworks. For four days, twelve healthy Black adults completed baseline surveys and self-collected saliva samples 4x/day to determine cortisol and alpha amylase as a proxy of HPA and ANS systems, respectively. Multilevel models were used to investigate the relationship between racial misogation and stress responses. Also, microaggressions were strongly associated with the diurnal cortisol slope in the same day, implying that on a day when people reported more microaggressions than normal, a flatter diurnal slope of cortisol was seen. The simultaneous use of salivary biomarkers and EMA was a valid way to investigate the temporal correlation between racial discrimination and physiological stress responses. The stress responses could be aided or delayed by an inside-person approach.

Source link: https://europepmc.org/article/MED/36103465


Cortisol-producing adenoma-related somatic mutations in unilateral primary aldosteronism with concurrent autonomous cortisol secretion: their prevalence and clinical characteristics.

Objection Concurrent autocortisol secretion in patients with primary aldosteronism is becoming more popular. It is unknown if these mutations in unilateral PA patients undergoing simultaneous with ACS are present. Methods 98 patients from the Taiwan Primary Aldosteronism Investigation registry who were enrolled in an overnight 1-mg dexamethasone suppression test and adrenalectomy from 2016 to 2018 were enrolled. CPA-related mutations in 11 patients were identified by 11 patients. Patients with these mutations had elevated post-DST cortisol and greater adenoma. After adrenalectomy, little more complete clinical results of uPA patients with these mutations was discovered, although it was statistically non-significant. These mutations were found to be related to the presence of these mutations, as demonstrated by Post-DST cortisol levels, adenoma size > 1. 9 cm, and the interaction of adenoma size > 1. 9 cm with potassium level. Conclusion Our report showed that CPA-related mutations were present in 36. 7% of uPA/ACS adenomas.

Source link: https://europepmc.org/article/MED/35900323


Household income, cortisol, and obesity during early childhood: A prospective longitudinal study.

The NET-Works Survey's baseline, 12-, 24-, and 36-month follow-up visits measured household income, child hair cortisol levels, and BMI of the 95th percentile trajectories using adjusted linear growth curve models were measured at baseline, 12-, 24-, and 36-month follow-up visits. Children from very poor households at baseline had annual BMIp95 readings that were higher than those from reference group households. Hair cortisol concentrations among children from households with rising income did not differ significantly from the reference group, with children from very low-income households having higher hair cortisol accumulations than reference group children, while increasing income children had higher hair cortisol levels. Conclusions The economic situation of families can influence children's BMI trajectories and their evolving stress processes, but these processes can differ from one another.

Source link: https://europepmc.org/article/MED/36113639


Expression of the angiogenesis marker endocan in Cushing's syndrome due to cortisol producing adenoma

Purpose: In this research, we wanted to investigate endocan expression in tissue samples of patients with Cushing's syndrome due to Cortisol-Productivity-Adenoma and compare it to normal adrenal cortex tissue, as well as determining the correlations of endocan expression with clinical and histopathological characteristics. In the study, 11 patients who were treated for CS due to CPA between 2009 and 2021 were included, as well as 14 control subjects with normal adrenal cortex. Result:: : The number of subjects with positive endocan expression and the mean endocan expression level in the CS group was significantly higher than the control group compared to the control group. Endocan expression and medical and histopathological characteristics of CPA tissue may be related to CPA's hormonal stability.

Source link: https://europepmc.org/article/PPR/PPR544337


Predictive Value of Early Postoperative Course of Serum Cortisol After Transsphenoidal Surgery for Cushing's Disease.

During the postoperative course, serum cortisol levels were monitored every four hours at least until the next morning. In the case of recurrence following remission, receiver operating characteristic curves were used to determine sensitivity, specificity, positive predictive value, and negative predictive value of various cut-off values of serum cortisol in the postoperative course. Those with recurrence differed in cortisol levels beginning from 4 p. m. on the day of surgery plus, an event of higher cortisol during the early postoperative course compared to patients with persistent long-term remission. Binary logistic regression showed the connection between a peak of serum cortisol in the early postoperative course and an elevated risk of recurrence. Patients with a peak of serum cortisol in the early postoperative course have an elevated recurrence rate. Patients with later recurrence could not be identified with a cut-off value of serum cortisol for prompt detection of patients with later recurrence.

Source link: https://europepmc.org/article/MED/36084942


Prenatal stress assessment using heart rate variability and salivary cortisol: A machine learning-based approach.

Methods ECG signals and salivary cortisol were determined from 29 pregnant women as part of a cross-section study involving a common acute psychological stress exposure and a control non-stress condition. Results On graphical display, an immediate difference in heart rate, HRV parameters, and cortisol were evident among 17 participants between the two visits, which enabled the stress assessment device to distinguish between stress and non-stress exposures with greater precision. The eight participants did not have a clear difference between HR and HRV measurements, but they did show a significant rise in cortisol following stress compared to non-stress conditions. When combining salivary cortisol with HR and HRV parameters, our machine learning software shows acceptable accuracy in detecting acute distress among pregnant women.

Source link: https://europepmc.org/article/MED/36084123


Performance of glucagon stimulation test in diagnosing central adrenal insufficiency in children when utilising the Roche Elecsys ® cortisol II assay: a pilot study.

Objects The glucagon stimulation test is used for the simultaneous assessment of central adrenal insufficiency and growth hormone deficiency. The GST's success in diagnosing central adrenal insufficiency was also comparable to that of the overnight metyrapone test. The GST, the post-metyrapone serum 11-deoxycortisol, and adhocorticotropin levels of the ONMTPT were all recorded in peak serum cortisol. sensitivity, precision 0. 64, positive predictive value 0. 60, negative LR 1. 12 and negative LR 1. 12, sensitivity of the post-GST C-level at 374 nmol/L was 0. 40, specificity 0. 64, negative predictive value 0. 64, positive predictive value 0. 64, negative predictive value 0. 60, and negative LR 1. 12. Conclusions This report shows that the GST at any C II cut-off will not be able to replace the ONMTPT as a diagnostic tool for CAI in children.

Source link: https://europepmc.org/article/MED/36062297


Mothers' and fathers' reflective functioning and its association with parenting behaviors and cortisol reactivity during a conflict interaction with their adolescent children.

During a parent-child conflict interaction task, we investigated parental reflective practices with the Parent Development Interview-Revised and Investigated, looking at its connection with parenting habits, that is, autonomy protection and psychological monitoring, as well as stress responses. Higher grades of PRF predicted greater emotional control than sex per se, rather than sex per se. Parental sex and divorced family status were neither correlated to autonomy nor to psychological control, and only in the context of parenting stress was best predicted by divorced family status and parental sex.

Source link: https://europepmc.org/article/MED/36066849


Loneliness and diurnal cortisol levels during COVID-19 lockdown: the roles of living situation, relationship status and relationship quality.

During the first lockdown in Germany, we investigated living conditions, marital status, and quality as potential moderators for trait and state loneliness, salivary cortisol levels in healthy adults. Participants with a partner and those who were living separately reported loneliness levels similar to singles living alone. Living alone was associated with elevated loneliness levels. In predicting cortisol, hierarchical linear models showed a significant cross-level relationship between relationship status and momentary loneliness.

Source link: https://europepmc.org/article/MED/36064567


Antibody-Coated Wearable Organic Electrochemical Transistors for Cortisol Detection in Human Sweat.

Although wearable antibody-based biosensors can provide real-time and simple detection of antigens, an accurate and low-cost antibody-based cortisol detection by electrochemical methods is extremely difficult due to its low density and high ionic strength of real biofluids. Based on antibody-coated organic electrochemical transistors, a label-free and fast sensor for cortisol detection is suggested here. Cortisol sensing in high-ionic-strength solutions with accurate cortisol detection in real human sweat, as shown by real human sweat.

Source link: https://europepmc.org/article/MED/36054907

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions