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Congenital Syphilis - Springer Nature

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Last Updated: 28 January 2023

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Congenital syphilis in the twenty-first century: an area-based study

All newborns and children aged from January 2010 to June 2022 were exposed to Treponema pallidum in utero and/or congenitally infected at the Federico II University of Naples' Perinatal and Pediatric Infectious Disease Units, enrolling all infants and children from January 2010 to June 2022. The majority of CS cases had normal clinical signs. The number of referred neonates tripled since 2017, but the prevalence of late maternal diagnoses did not significantly differ. When compared to mothers of exposed infants, mothers of CS cases were younger, had less recent pregnancies, and received a diagnosis of syphilis at a later stage of pregnancy. In 36 percent of cases, paternal syphilis status was present. Specific maternal risk profiles should be used to develop specific maternal risk profiles. What is New: U2022 Congenital syphilis has a major effect in Europe, and prevention should be targeted to specific maternal risk profiles.

Source link: https://doi.org/10.1007/s00431-022-04703-5


Congenital syphilis in a preterm newborn with gastrointestinal disorders and postnatal growth restriction

Congenital syphilis is characterized by the transfer of Treponema pallidum spirochetes from an infected mother to fetus during pregnancy. Due to the combined pathogenic effect of both CS and prematurity, premature infants with CS may have more severe signs of disease than those without CS. Presentation of a female preterm newborn The majority of typical CS symptoms are present in addition to gastrointestinal disorders such as feeding difficulties, colon stenosis, and malabsorption leading to postnatal growth restriction. The mother tested positive on the syphilis screening test of pregnancy's first trimester, but she did not undergo any intervention. Our newborn was VDRL positive at birth, and she was treated with intravenous benzylpenicillin G for ten days. Within the descending tract, A barium enema X-Ray detected a colon stenosis. After the introduction of an amino acid-based formula, an increase in enteral feeding was recorded, with no further and significantly reduced episodes of abdominal distension and vomiting, respectively, as well as regular stool release at 5 months of age, following the introduction of an amino acid-based product. A psychological help to the family's increased bond with the mother and her baby was a significant improvement in food tolerance and growth. Conclusions Our study reveals that less common gastrointestinal CS signs such as feeding difficulties, colon stenosis, and malabsorption contribute to postnatal growth lagout. CS may be present in high-income countries, with high incidences of antenatal screening and prenatal care.

Source link: https://doi.org/10.1186/s13052-022-01404-5

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions