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We report a case of fetal T. pallidum infection and premature delivery in a woman whose syphilis testing was negative at 16 weeks of gestation. This case shows that even if early syphilis testing of pregnant women is negative, they can also be infected with T. pallidum later on in pregnancy. T. pallidum infection should be excluded in patients with a rash without a definite cause. The abovementioned factors may have reduced the risk of T. pallidum infection in pregnant women and their infants.
Source link: https://doi.org/10.3389/fpubh.2022.1073893
Abstract Background This congenital syphilis is influenced by Treponema pallidum spirochete transmission from an infected mother to fetus during pregnancy. Due to the combined pathogenic effect of both CS and prematurity, premature infants with CS may have more severe signs of disease than those without. Presentation of the case We present a case study of a female preterm newborn with the majority of the typical CS symptoms, in comparison to gastrointestinal disorders such as feeding difficulties, colon stenosis, and postnatal growth restriction. The mother did not receive any drugs after a positive syphilis screening test during the first trimester of pregnancy, but she did not seek any intervention. Our infant was VDRL positive at birth, and she was treated with intravenous benzylpenicillin G for ten days. Within the descending tract, A barium enema X-Ray detected a colon stenosis. An improvement of enteral feeding was recorded after the introduction of an amino acid-based product at 5 months of age, with no more and significantly reduced episodes of abdominal distension and vomiting respectively, as well as regular stool leaks at 5 months old. A psychological assistance to the family created a more stable relationship between the mother and her child, thus providing the mother with a significant boost in food tolerance and growth. Conclusions Our study reveals that gastrointestinal disorders such as feeding difficulties, colon stenosis, and malabsorption contribute to postnatal growth delay. CS may be present in high-income countries, with high rates of antenatal screening and prenatal services available.
Source link: https://doi.org/10.1186/s13052-022-01404-5
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