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Computational Biology - Springer Nature

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Last Updated: 10 January 2022

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Targeting CK2 mediated signaling to impair/tackle SARS-CoV-2 infection: a computational biology approach

Background Similarities in the hijacking mechanisms used by SARS-CoV-2 and numerous kinds of cancer cells, recommend the repurposing of cancer drugs to treat Covid-19. CK2 kinase antagonists have been proposed for cancer treatment. Next, we incorporated information from multi-omics research studies and information concentrating on the hostile impact on the CK2 kinase activity of CIGB-300. Results Firstly, from the SARS-CoV research studies, we presumed the possible occurrence of CIGB-300 in SARS-CoV-2 interference on the immune response. After that, from the evaluation of multiple omics information, we proposed the activity of CIGB-300 from the beginning of viral infections perturbing the virus hijacking of RNA splicing equipment. We additionally forecasted the disturbance of CIGB-300 in virus-host interactions that are responsible for the high infectivity and the specific immune response to SARS-CoV-2 infection.

Source link: https://doi.org/10.1186/s10020-021-00424-x

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions