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Breast cancer survivorship is almost entirely a result of tumor metastasis and resistance to therapy, and therefore understanding the underlying mechanisms is an emerging problem. Following resection of a triple-negative breast tumor, the production of complement factors in lung fibroblasts was stimulated by complement factors and improved an immunosuppressive metastatic niche that promoted lung metastasis. Our results indicate that combining cytotoxic therapy with blockade of complement signaling in triple-negative breast cancer patients may reduce the adverse effects of chemotherapy, providing a promising treatment option for clinical use.
Source link: https://www.ncbi.nlm.nih.gov/bioproject/859133
Age-related macular degeneration, one of the leading causes of blindness worldwide, contributes to personal suffering and high socioeconomic costs, as well as high socioeconomic burdens. Though advancements have been made in the treatment of AMD's neovascular variant of the disease, no drugs are yet available for the more popular dry form, also known as geographic atrophy. To determine the underlying pathology, we analyzed retinal tissue in a mouse model of retinal degeneration triggered by sodium iodate-induced retinal pigment epithelium atrophy. Patchy RPE loss and thinning of the photoreceptor layer were associated with NaIO3's patchy RPE loss and thinning of the photoreceptor layer. At day 10, retinal degeneration was upregulated in retinal degeneration. Proinflammatory ccl-2, -3, -5, IL-33, and tgf-b were all elevated in NaIO3 mice's retinas, but vegf-a mRNA were reduced. Local retinal inflammatory changes in the NaIO3 retina could be a cellular source for local retinal inflammatory changes.
Source link: https://www.ncbi.nlm.nih.gov/bioproject/781828
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