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Colorectal Cancer - Wiley Online Library

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Last Updated: 19 January 2023

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Novel strategies to reverse chemoresistance in colorectal cancer

Abstract Colorectal cancer is a common digestive disease with elevated morbidity and fatality. Chemotherapy, as traditional CRC treatment, has exhibited a strong antitumor function and greatly improved CRC patients' survival. However, chemoresistance is one of the key issues during chemotherapy for CRC, and it significantly limits the effectiveness of the therapy and influences patient prognosis.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/cam4.5594


Multicellular Quadruple Colorectal Cancer Spheroids as an In Vitro Tool for Anti‐angiogenic Potential Evaluation of Nanoparticles

The encapsulation of bevacizumab, angiogenesis inhibitor antibody, has been investigated into nanocarriers with the intention of improving its colorectal cancer therapy while still avoiding potential side effects. The CRC's development of a multicellular spheroid of CRC was suggested herein as an advanced pre-u2010clinical model of CRC capable of determining novel nanomedicines' anti-u2010angiogenic properties. When compared to free BVZ, Gellan gum/chitosan nanoparticles encapsulating BVZ displayed superior anti-u2010angiogenic activity. Overall, the produced nanoparticles could be explored more as a promising treatment for CRC patients.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/adtp.202200282


Circ‐ERBB2 knockdown sensitized colorectal cancer cells to 5‐FU via miR‐181a‐5p/PTEN/Akt pathway

MiR2010181a-u20105p's CRC cells had no effect on miRu2010181a/u20505p silencing in CRC cells, which was contrary to circ/u2010ERBB2 and miR 2010181a u20105p downregulation, which abolished the role of circ-u2010ERBB2 silencing in CRC cells. circ 2005181a's u2010181a. Circu2010ERBB2 silencing dramatically reduced CRC cell resistance to 5u2010FU, according to Circ. In CRC cell resistance to 5u2010FU, MiR’u2010181a is a United states politician who ruled that downregulation of around u2010ERBB2 reduced the role of circu2010ERBB2 knockdown to 5 percent in U2010FU to 5 u2010FU. In addition, a new mechanism research showed a novel regulatory pathways that circumscribed u2010ERBB2 knockdown, increasing cell sensitivity to 5 u2010FU by regulating the miR2010181a/PTEN/Akt pathway. Ciru2010ERBB2 was found to be a valuable biomarker for CRC diagnosis and treatment. This research indicated that circu2010ERBB2 may be a useful biomarker for diagnosis and treatment of CRC.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/jbt.23297


Tumor deposits in colorectal cancer: Refining their definition in the TNM system

Abstract Tumor deposits are discontinuous tumor formation in the mesocolon/mesorectum, which is present in approximately 20% of colorectal cancer and negatively influences survival. paraphrasedoutput:u201d In several studies using the u201ccounting technique, the effectiveness of an alternative staging strategy has been shown consistently. u201d In multiple studies using the u201ccounting method, all nodular type TDs are individually counted together with positive LNs to derive the final pN, resulting in a prognostic and diagnostic value that is superior to existing TNM systems. Although the TNM system has long relied on TDs for determining its categorization, it's time to open alternative options and start a international discussion on the optimal treatment of TDs in tumor staging; otherwise, a significant number of patients will miss the opportunity to receive the right adjuvant therapy.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/ags3.12652


Potential role of volatile organic compound breath testing in the Australasian colorectal cancer pathway

With colonoscopy resources under pressure and inequitable participation rates in our screening services, there is urgent need to investigate the possibility of testing new techniques for the detection of colorectal cancer in Australasia. Flexible organic compounds emitted from the human body can act as biomarkers for CRC early and late-stage CRC, as well as adenomatous polyps. This report summarizes the current state of knowledge in using VOC-u2010-based methodologies for CRC testing. CRC patients should be specifically targeted at various points along the CRC patient path.

Source link: https://onlinelibrary.wiley.com/doi/10.1111/ans.18195


Hsa_circ_0079480 enhances cell proliferation, migration, and invasion in colorectal cancer through miR‐498/ATP5E axis

Using quantitative real time polymerase chain reaction assay, Hsa_circ_0079480, miR2010498, and ATP5E expressions in CRC tissues and CRC cells were determined in CRC tissues and CRC cells. An experiment was done to investigate the interactions between hsa_circ_0079480, miR_u2010498, and ATP5E. According to this report, hsa_circ_0079480 and ATP5E expressions were significantly elevated in CRC tissues and CRC cells, while miRu2010498 was downregulated. Meanwhile, it turned out that hsa_circ_0079480 knockdown stymied CRC tumor formation in vivo. Hsa_circ_0079480 could negatively influence miR's expression by specifically attacking MiR2010498. MiRu2010498's overexpression significantly stifled CRC cell malignant activity. By specifically binding to ATP5E, miRu2010498 negatively limited ATP5E expression by ubiquitically binding to ATP5E. A ATP5E knockdown mistook CRC cell malignant activity by suppressed CRC cell malignant behaviours, according to a ATP5E knockdown. The inhibitory effect of hsa_circ_0079480 on CRC cell malignant behavior was minimized by ATP5E overexpression, which reduced the inhibitory effect of hsa_circ_0079480 on CRC cell malignant behaviors. Since the hsa_circ_0079480 knockdown stymied CRC cells' malignant activities by tightening the miR's/ATP5E axis, it can be concluded that hsa_circ_0079480 could be a promising therapeutic target for CRC cells.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/kjm2.12616


Identification of faecal extracellular vesicles as novel biomarkers for the non‐invasive diagnosis and prognosis of colorectal cancer

The extracellular vesicles in CRC patients' faeces could act as a potent biomarker for CRC's non-invasive diagnosis and prognosis. The detection findings reveal that CD147 and A33 on fEVs were upregulated in CRC patients, thus distinguishing them from healthy donors. The CD147/A33u2010enriched fEVs may be used as new-u2020scale, non-invasive CRC screening, as well as real-time monitoring of patient outcomes during clinical intervention studies.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/jev2.12300


Association of KMT2C/D loss‐of‐function variants with response to immune checkpoint blockades in colorectal cancer

In the LOF group, the number of patients with MSIu2010H tumors was higher than in the non-u2010LOF group. In both the Chinese and TCGA cohorts, the PD/u2010L1 expression was highest in the LOF group only for colorectal cancer. Importantly, KMT2C/D LOF variants were attributed to decreased regulatory T cells and elevated levels of CD8+ T cells, stimulated NK cells, M1 macrophages, and M2 macrophages in colorectal cancer. However, there was no significant correlation between KMT2C/D LOF and TILs levels in other cancer types. In a Chinese colorectal cancer cohort, the patients with KMT2C/D LOF mutations exhibited improved clinical response to anti-u20101 therapy. These results, taken together, show that KMT2C/D LOF variants may be a good predictor of ICIs use in colorectal cancer. In comparison, the predictive value of KMT2C/D LOF variants was consistent with their association with TILs levels.

Source link: https://onlinelibrary.wiley.com/doi/10.1111/cas.15716


Therapy with pembrolizumab in treatment‐naïve patients with non‐metastatic, mismatch repair deficient colorectal cancer

Patients with metastatic mismatch deficient colorectal cancer are able to be cancer-free; however, studies on neoadjuvant ICI therapy in patients with locally advanced CRC are limited. Five Danish oncological centers treated ten patients with pre-u2010nau201efficial colon cancer, 9 with a non-u2010metastatic, unresectable colon cancer, and 1 with a locally advanced rectum cancer from March 2019 to June 2020. No remaining tumor cells were found in 5 patients, according to a microscopic analysis, although 5 patients had tumor cells present, although 5 patients had tumor cells. According to 19% of the patients with colon cancer and 1. 5 percent of those with rectum cancer had an dMMR tumor in 2017.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/ijc.34420


Retraction: CircRNA_103948 inhibits autophagy in colorectal cancer in a ceRNA manner

The following essay, which was originally published online in Wiley Online Library on September 3, 2021, has been retracted by agreement between the authors, the journal Editor, u2010Chief, and Wiley Periodicals LLC. The authors informed the journal that they were unable to confirm or replicate the experimental findings of the transmission electron microscopy examination and autophagosome detection shown in Figure 6. In a ceRNA manner, CircRNA_103948 hinders autophagy in colorectal cancer.

Source link: https://onlinelibrary.wiley.com/doi/10.1111/nyas.14955

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions