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Colorectal Cancer - Wiley Online Library

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Last Updated: 19 July 2022

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Calycosin suppresses colorectal cancer progression by targeting ERβ, upregulating PTEN, and inhibiting PI3K/Akt signal pathway

Fiberectal cancer prevention has been traced to a high intake of phytoestrogen. In our previous research, Calycosin belongs to a phytoestrogen that has been shown to reduce CRC cells. This research investigated the effect of calycosin on human CRC HCT116 and SW480 cells' viability and apoptosis of human CRC HCT116 and SW480 cells' viability and apoptosis by MTT assay, flow cytometry assay, and caspaseu20103/7 activity assay. And then, the alterations of biological activity in CRC cells transplanted with ERu03b2 siRNA were determined. The antitumor effect in vivo was investigated in mouse xenograft models. The results show that calycosin decreases CRC cell viability, promotes cell differentiation, and minimizes xenograft tumor formation. Following calycosin therapy, the protein expressions of ER-u03b2 and PTEN have been highly enhanced, whereas pu2010AKT/AKT ratio and Bclu20102 value have been significantly reduced, while the Bcl/Bcl/Bcl u20132 ratio and Bclu20102 level have been significantly downregulated, while ru2013AKT/AKT ratio and Bclu2010AKT/u2013AKT/T utin treatment, u002 and Phe u03b2 and PTEN are greatly u002 and PTM/AKT/AKT/AKT/AKT/U20102 levels are significantly increased, u20102u2010AKT/B2U20102u20102 and Pu20102u20102B2u20102u20102u20102u20102u20102u20102u20102u20102u20132u20102u20102u20132/BCT.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/cbin.11840


Total flavonoids from the dried root of Tetrastigma hemsleyanum Diels et Gilg inhibit colorectal cancer growth through PI3K/AKT/mTOR signaling pathway

In southern China, the dried root of Tetrastigma hemsleyanum Diels et Gilg is used as a common Chinese medicine as a folk remedy for cancers and gastrointestinal disorders. T. hemsleyanum's total flavonoids are the primary bioactive constituents. We investigated the antitumor effects of THTF on colorectal cancer in vitro and in vivo. THTF delayed colorectal tumor formation by banning the PI3K/AKT/mTOR pathway, thus making it a potential candidate for colorectal cancer prevention, according to the study.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/ptr.7561


The potential role of prebiotics, probiotics, and synbiotics in adjuvant cancer therapy especially colorectal cancer

Abstract Cancer is a global health problem that is quickly rising, with younger people and an increasing number of patients. Microecologics have anti-u2010cancer activity, and their potential connection with cancer is strong. In addition, other research has shown the importance of microecological agents to supplement chemotherapy and counter the toxic side effects of cancer drugs. Prebiotics, probiotics, synbiotics, and their use in cancer patients can be seen as a medical benefit, although the effect can be considered a clinical benefit.

Source link: https://onlinelibrary.wiley.com/doi/10.1111/jfbc.14302


The Emerging Era of Personalised Medicine in Advanced Colorectal Cancer

Colorectal cancer is a genetically heterogeneous disease with its pathogenesis often triggered by a combination of genetic or epigenetic mutations. The results of the tumor microenvironment's pivotal role in cancer growth and dissemination were published by a deep molecular analysis. A personalized approach tailoring therapy based on individual tumor's histopathological and molecular characteristics can potentially lead to improved patient outcomes and a reduced incidence of recurrence in patients with advanced CRC.

Source link: https://onlinelibrary.wiley.com/doi/10.1111/jgh.15937


Developing and validating polygenic risk scores for colorectal cancer risk prediction in East Asians

Several polygenic risk scores have been developed to identify the risk of colorectal cancer in European descendants. In two case-u2010control studies, we used genome-wide association study data from 22,702 cases and 212,486 controls of Asian ancestry to create PRS and validated them. According to three methods, GWAS-u2010identified CRC risk SNPs, CRC risk variants were identified through fine-u2010mapping of known risk loci, and genome-u2010-wide risk prediction tools. OR per SD increase of PRS115. 60EAS was 1. 63, compared to OR 1. 44 for PRS115u2010EUR. Individuals in the top 5% of PRS115. u2010EAS/EUR have a 2. 52 percent elevated CRC risk compared to the medium risk group and have a 12 percent risk of developing CRC by age 85, with a 120% chance of experiencing CRC by age 85. Our findings show that CRC PRS are effective in predicting CRC risk in East Asians, as well as highlighting the importance of using population-specific data to develop CRC risk prediction models.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/ijc.34194


Salivary metabolomics with machine learning for colorectal cancer detection

Abstract As the worldwide prevalence of colorectal cancer is increasing, it is important to minimize morbidity and mortality by early detection. Here, we investigated and tested salivary biomarkers to distinguish patients with CRC from those with adenoma and healthy controls. Patients with CRC, AD, and HC were tested for Saliva samples, which were collected from patients with CRC, AD, and HC. Untargeted salivary hydrophilic metabolite profiling was carried out using capillary electrophoresis spectrometry and liquid chromatography, according to U2013mass spectrometry. CRC, AD, and HC samples were collected by a number of 2602 unstimulated saliva samples. The ADTree model was refined by cross-u2010validation using the training dataset, and the validated model was verified using the validation dataset. 0. 960 for CV and 0. 870 for the validation dataset, which was consistent with the receiver-u2010operating characteristic curves. According to the other model distinguishing CRC from AD + HC, there were AUCs of 0. 79 and 0. 870, respectively.

Source link: https://onlinelibrary.wiley.com/doi/10.1111/cas.15472


Colonoscopy decreases mortality in colorectal cancer patients compared with fecal immunochemical test

Background and Aim Colonoscopy and fecal immunochemical testing are common screening techniques for the detection of colorectal cancer, but their effects on survival have not been compared. We compared survival outcomes in patients with CRC as a result of colonoscopy or FIT before diagnosis of CRC. Methods We conducted a national populationu2010insurance claims survey using Korean national 2011insurance claims data. In total, 24 875 patients with CRC diagnosis in 2012 were included. In comparison to the never-u2010screened group, the adjusted hazard ratios for death were 0. 56 in the colonoscopy group and 0. 78 in the FIT group. The adjusted hazard ratios for death in the matched cohort were 0. 76 in the colonoscopy group in comparison to the FIT group. Conclusions Comparing to FIT, colonoscopy is a more cost-effective strategy for reducing mortality in patients with CRC.

Source link: https://onlinelibrary.wiley.com/doi/10.1111/jgh.15924


DNA methylation biomarkers in colorectal cancer: Clinical applications for precision medicine

Colorectal cancer is the second leading cause of cancer death worldwide, owing to gradually increasing genetic and epigenetic changes over time. A panel of DNA methylation markers has been published over the last decade, with a high degree of reproducibility and reproducibility in a variety of semi-invasive or noninvasive biosamples. In addition, epigenetic revisions for cancer therapy as a precision medicine approach will increase their therapeutic effectiveness over time. We'll be reviewing the current state of DNA methylation based biomarkers and their effects on CRC diagnosis here.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/ijc.34186


Long non‐coding RNA TDRG1 aggravates colorectal cancer stemness by binding with miR‐873‐5p to upregulate PRKAR2

In several tumors, the effects of long non-coding RNA TDRG1 have been identified; however, its roles in colorectal cancer progression have yet to be discovered. Here, we found that the TDRG1 level in CRC cells was elevated in comparison to that in normal colon epithelial cells. TDRG1 knockdown reduced the stemness of CRC cells, both in vitro and in vivo.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/tox.23602


RING finger protein 128 (RNF128) regulates malignant biological behaviors of colorectal cancer cells via PI3K/AKT signaling pathway

This research was designed and conducted to determine the effects of RNF128 expression on malignant biological characteristics of colorectal cancer cells and the underlying mechanism. RNF128 gene expression in CRC tissues was determined by mRNA sequencing results from the TCGA database and was confirmed by Western blot assay. In addition, tumor xenograft models in nude mice were created to investigate the relationship between RNF128 expression and tumor formation in vivo. Both RNF128 mRNA and protein were significantly elevated in CRC tissues, and CRC tissues' expression levels were also elevated. Cell growth, antiapoptosis, migration, and invasion were all suppressed by RNF128's knockdown in vitro, including cell growth, antiapoptosis, migration, and invasion. RNF128 functions as a tumor promoter in CRC's pathogenesis by regulating the PI3K/AKT pathway, making it a good candidate for CRC therapy, and it could be a useful target for CRC therapy.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/cbin.11835

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions