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Gut microbes are able to tell CRC by metabolites, but how the metabolites affect CRC is largely unknown. We investigated fecal metabolites associated with mouse models of colon tumorigenesis in mice models of colon tumorigenesis with varying mutational load. Lactobacillus reuteri and its metabolite, reuterin, are downregulated in mouse and human CRC, according to Microbial profiling. Reuterin causes selective protein oxidation and determines ribosomal biogenesis and protein translation, as well as inhibits protein synthesis and protein translation. In vivo, Exogenous Lactobacillus reuteri restricts colon tumor formation, increases tumor reactive oxygen species, and reduces protein translation.
Source link: https://doi.org/10.1016/j.ccell.2021.12.001
A rise in colorectal cancer incidence in young men and women, which is usually chemoresistant, according to emerging reports. Here, we investigated the role of TGF-u03b2 signaling on the intestinal microbiome and the safety of chemotherapy for CRC caused by azoxymethane and dextran sodium sulfate in mice. We investigated gut microbiota composition in mice with CRC and discovered reduced amounts of beneficial Bacteroides and Parabacteroides in the mutants relative to wild-type mice by using shotgun metagenomic sequencing. In addition, the mutant mice with CRC were not able to 5FU. E. boltae, B. dorei, Lachnoclostridium sp. , and Mordavella sp. are among the many E. boltae, B. dorei, Mordavella sp. In mice with CRC mice, the response to 5FU was dramatically reduced, but these mice were only recovered to basal levels after 5FU treatment, suggesting that the changes in the intestinal microbiome caused by defective TGF-u03b2 signaling impaired the response to 5FU.
Source link: https://doi.org/10.1016/j.bbadis.2021.166179
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