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Colorectal Cancer - Springer Nature

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Last Updated: 19 July 2022

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Upregulated LINC01088 facilitates malignant phenotypes and immune escape of colorectal cancer by regulating microRNAs/G3BP1/PD-L1 axis

LINC01088 is a newly found long non-coding RNA that was long-coding RNA that was not coding RNA and has long been present on Long RNA. . In vivo, xenograft tumor mouse models were created. Conclusions We discovered that LINC01088 was significantly upregulated in colorectal cancer tissues and CRC cell lines, compared to adjacent normal tissues and colonic epithelial cells. Patients with CRC had negative outcomes when LINC01088 levels were linked to adverse outcomes. LINC01088 was linked directly to miR-548b-5p and miR-548c-5p, a shortening CRC cell phenotypes, and a genetically modified Ras GTPase-binding proteins 1 and programmed death ligand 1 expression. LINC01088 knockdown restricted CRC tumor formation and lung metastasis in mouse xenograft models, reducing CRC tumor formation and lung metastasis. Notably, LINC01088's downregulation of PD-L1 expression, but G3BP1 overexpression of PD-L1 in xenograft tumors restored PD-L1 gene expression in xenograft tumors. Besides, the LINC01088 knockdown has slowed CRC organoid growth ex vivo. Conclusion These results showed that LINC01088 specifically targeted miR-548b-5p and miR-548c-5p, encouraging G3BP1 and PD-L1 expression, which helped with colorectal cancer progression and immune escape.

Source link: https://doi.org/10.1007/s00432-022-03981-8


National differences in implementation of minimally invasive surgery for colorectal cancer and the influence on short-term outcomes

Background The timing and extent of implementation of minimally invasive surgery for colorectal cancer in different countries vary. This survey also sought to determine differences in patient selection, applied methods, and findings of minimally invasive surgery for colorectal cancer between the Netherlands and Sweden. Patients who underwent elective minimally invasive surgery for T1-3 colon or rectal cancer were included in the Dutch ColoRectal Audit or Swedish ColoRectal Cancer Registry. Output: Outcomes were compared to time periods when a similar degree of MIS implementation was present. If compared to MIS in Sweden during 2017u20132018, a higher reoperation rate for colon cancer and a higher readmission rate resulted in a higher readmission rate, as well as lower non-surgical complications for rectal cancer in the Netherlands for the years 2012–2013. Conclusions This research found that the introduction of MIS for colorectal cancer in Sweden took place later in Sweden than in the Netherlands, resulting in similar outcomes despite lower volumes.

Source link: https://doi.org/10.1007/s00464-021-08974-1


Increasing Colorectal Cancer Incidence Before and After Age 50: Implications for Screening Initiation and Promotion of “On-Time” Screening

Background Early onset colorectal cancer incidence is on the rise among individuals born 1950 to later, with a birth cohort association to increased incidence among individuals born 1950 and later. It is unclear if rising incidence trends will pose an increased risk beyond age 50, the previously recommended age to start screening, but screening availability could change incidence trends. Average Annual Percent Change in cancer incidence by age subgroup was used to determine Average Annual Percent Change in cancer incidence by age subgroup. Results 470,458 CRC cases were recorded by age 40u201359, with absolute numbers of rectal and distal cancer cases per year for age 50 to 70,000-2009 records by 2017. Age 40u201354, from 4. 9 to 6. 3, with age 45 to 12,0 for age 45u201354, and from 16. 7 to 19. 5 for age 50, U201354.

Source link: https://doi.org/10.1007/s10620-021-07213-w


Colorectal Cancer Cell Differentiation Is Dependent on the Repression of Aerobic Glycolysis by NDRG2-TXNIP Axis

Background: Colorectal cancers that are poorly differentiated are more aggressive. However, how cancer cells reproprogramming glucose metabolism contributes to cell differentiation was largely unknown. Previous studies have shown that tumor suppressor NDRG2 may be able to promote colorectal cancer differentiation. MTT assay was used to demonstrate cell viability and proliferation. NDRG2 has been shown to inhibit cell proliferation, glucose uptake, and decrease the expression of key glycolysis enzymes in colorectal cancers. However, the deletion of TXNIP, a common glucose metabolism inhibitor, may alter the function of NDRG2 in differentiation, glucose uptake, expression of key glycolysis enzymes, and proliferation. The development of TXNIP promoters is aided by a high glucose flux, mechanistically. Mondo A on TXNIP's promoter, predominantly via the suppression of c-myc, which could come to an end with Mondo A binding to the TXNIP promoter. And NDRG2 supports transcription factor Mondo A on TXNIP promoter. TXNIP-dependent induction of TXNIP in colorectal cancer differentiation is vital for aerobic glycolysis during aerobic glycolysis.

Source link: https://doi.org/10.1007/s10620-021-07188-8


Training prediction models for individual risk assessment of postoperative complications after surgery for colorectal cancer

We developed prediction software for estimating patient risks of complications based solely on preoperatively available data in a multidisciplinary team setting. Knowing beforehand of surgery, the possibility of obtaining a complication may assist in improving informed decision-making by surgeon and patient and individualize surgical treatment trajectories. Methods The national Colorectal Cancer Group website held a registry of patients over 18 years of age between January 1, 2014 and December 31, 2019. The database's results were turned into the Observation Health Data Science and Informatics initiative, which was turned into the Observation Medical Outcomes Partnership Common Data Model. Conclusions The prediction of postoperative complications based solely on preoperative variables using a national quality assurance colorectal cancer registry shows promise for estimating patient risk.

Source link: https://doi.org/10.1007/s10151-022-02624-x


A retrospective analysis using deep-learning models for prediction of survival outcome and benefit of adjuvant chemotherapy in stage II/III colorectal cancer

The majority of Stage II/III colorectal cancer patients can be treated by surgery alone, and only certain CRC patients benefit from adjuvant chemotherapy. Methods We trained and internally verified CRCNet using 780 Stage II/III CRC patients from Molecular and Cellular Oncology, as well as patients from Molecular and Cellular Oncology. From The Cancer Genome Atlas, 337 Stage II/III CRC patients were used to test the model independently. After accounting for new risk factors, multivariate Cox regression results reported that CRCNet risk groups are statistically significant. Conclusions The retrospective review shows that H&E image-based biomarkers may be of great use in delivering drugs following chemotherapy for Stage II/III CRC, increasing patient survival, minimizing unnecessary care and associated risks, as well as providing additional information on other studies and prospective validation in clinical trials.

Source link: https://doi.org/10.1007/s00432-022-03976-5


Recent Progress in Mass Spectrometry-based Metabolomics for Colorectal Cancer

Cancer is a disease that alters cellular metabolism, and metabolomics can play a key role in early diagnosis of cancer and the evaluation of medical interventions and therapies for cancer. Many metabolomics studies are based on high-sensitivity and high-throughput mass spectrometry systems. Colorectal cancer is the third most common disease worldwide, with the highest incidence in China being third. This essay discusses the latest advances in colorectal cancer research using mass spectrometry methods.

Source link: https://doi.org/10.1007/s40242-022-2119-5


Informational needs and predictors of Jordanian breast and colorectal cancer survivors: a national cross-sectional study

Methods A national cross-sectional survey of breast and colorectal cancer survivors was conducted in 2020 using a representative sample of patients diagnosed in 2015/2016 as enrolled from Jordan's Cancer Registry. Background details; information typologies determined on a 5-point Likert scale; time of publishing the data needs to be considered. The reliable association between demographics and information seeking behavior amongst refugees was used by logistic regression to determine the unidirectional relationship between demographics and information seeking behavior amongst survivors. ANOVA was used to measure the means of interest in cancer-related research among more than two organizations. Patients requiring immediate care following diagnosis and 23 percent experienced their needs within two months, and 58% of patients needed information immediately after diagnosis. Age was the only reliable predictor of high tech needs amongst cancer survivors. Survivors raised cancer awareness requirements, implying that they may have been under-informed. To satisfy the informational requirements, effective health information systems should be developed.

Source link: https://doi.org/10.1007/s00520-022-07110-6


Local Therapies for Colorectal Cancer Oligometastases to the Lung

Purpose of Investigation The growing consensus is that oligometastatic disease-directed therapy has improved oncologic outcomes in patients with colorectal cancer; however, the correct local administration of pulmonary oligometastases remains tense. Latest Results Although surgery has traditionally been regarded as the gold standard local treatment for pulmonary metastases, there are no prospective studies proving a significant benefit of pulmonary metastasectomy relative to other local treatment techniques, such as stereotactic radiotherapy or radiofrequency ablation, according to recent studies.

Source link: https://doi.org/10.1007/s11888-022-00477-y

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions