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Colorectal Cancer - PubAg

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Last Updated: 16 October 2021

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Prognostic effect of sarcopenia in colorectal cancer recurrence

We consider that nutritional condition at cancer recurrence is just one of the important variables that influence treatment option and strength. This research assessed the prognostic effects of improved postoperative nutritional condition for people with colorectal cancer recurrence. We enlisted 209 participants with pathologically validated stage II or III colorectal cancer that undertook extreme resection. Individuals with preoperative sarcopenia who fell back were separated into 2 teams at the time of reappearance: sarcopenia extension and sarcopenia renovation. Preoperative sarcopenia did not affect the cancer recurrence proportion. The sarcopenia-improvement group had higher total survival than the sarcopenia-continuation group. Among individuals with preoperative sarcopenia, the prognosis at the time of reappearance boosted for the sarcopenia-improvement team compared to the sarcopenia-continuation group. In people with colorectal cancer and sarcopenia, nutritional management is essential not only prior to but also after surgery.

Source link: https://pubag.nal.usda.gov/catalog/7405128


USP47 maintains the stemness of colorectal cancer cells and is inhibited by parthenolide

Colorectal cancer stem cells are implicated in colorectal tumor initiation, intrusion, recurrence and treatment resistance, so elucidation of the mechanism underlying the cancer stem cells induction and growth of drugs targeting CCSCs are crucial for cancer treatment. USP47 silencing decreases spreading and movement of colorectal cancer cells and reduces the self-renewal of CCSCs by downregulating the expression of cancer stem cell pens, including CD44, CD133, CD166, OCT4 and NANOG. Taken together, our findings highlighted an unique DUB entailed in the inflection of CCSCs stemness and the potential of PTL in the CRC treatment by targeting CCSCs as the USP47 prevention.

Source link: https://pubag.nal.usda.gov/catalog/7390992


Magnetic Nanoparticle-Based Hyperthermia Mediates Drug Delivery and Impairs the Tumorigenic Capacity of Quiescent Colorectal Cancer Stem Cells

Cancer stem cells are the lump cell subpopulation responsible for resistance to radiation treatment, growth recurrence, and metastasis. We below investigate the effect of magnetic hyperthermia in combination with neighborhood radiation treatment as a double therapy to hinder patient-derived colorectal qCR-CSCs. We apply iron oxide nanocubes as MHT warm arbitrators, covered with a thermoresponsive polymer and filled with DOXO as a chemotherapeutic agent. In colony-forming assays, the cells subjected to TR-Cubes with MHT reveal that qCR-CSCs struggle to endure the warm damages and, with a due hold-up, reactivate the department of inactive cells. The in vivo tumor development research confirms the combined effects of MHT with heat-mediated medication launch: only the team of pets that obtained the CR-CSCs pretreated, in vitro, with TR-DOXO and MHT did not have the formation of lump even after a number of months.

Source link: https://pubag.nal.usda.gov/catalog/7339006


Effects of kefir on doxorubicin-induced multidrug resistance in human colorectal cancer cells

Multidrug resistance versus chemotherapeutic agents often takes place in cancer cells, bring about cancer therapy failure. To explore the potential chemo-sensitizing results of kefir, drug-resistant human colorectal cancer cells were generated by revealing cells to 34 nm of doxorubicin for 12 weeks. Outcomes demonstrated that cells treated with kefir attenuated MDR and improved the anticancer impact of DOX in drug-resistant cells. Our information suggest that kefir intake may be useful in patients getting DOX radiation treatment owing to its chemo-sensitizing results.

Source link: https://pubag.nal.usda.gov/catalog/7254262


Immunomodulatory nanomedicine for colorectal cancer treatment: a landscape to be explored?

Colorectal cancer is one of the most dangerous cancers cells worldwide generally because of metastasis occasions. As is well understood, the immunosuppressive lump microenvironment plays a key function in tumorigenesis, promoting cancer cell immune escape and condition progression. In addition, gathering proof indicates that the immunosuppressive microenvironment is a crucial obstacle for antitumor immunity in CRC, being incredibly important to modulate the immune microenvironment to inhibit the tumor-promoting immune response.

Source link: https://pubag.nal.usda.gov/catalog/7362610


Identification of Key mRNAs and Pathways in Colorectal Cancer

Colorectal cancer is the third most cancer-related fatality worldwide. 3 gene expression datasets were accumulated from GEO datasets, including tumor example and surrounding nontumor cells example. RankProd was utilized to find the differential revealed genes in between growth and nearby nontumor cells for datasets created by various labs. The genetics established enrichment evaluation performed on the DE genetics, complied with by the healthy protein-- healthy protein communication network. Our data demonstrated integrated various sources of transcriptomes will advertise the understanding of the molecular mechanisms underlying CRC advancement and may be useful in uncovering prospect molecular biomarkers for identifying, prognosis, and treating of CRC.

Source link: https://pubag.nal.usda.gov/catalog/7366138


Dual-drug delivery system based on the hydrogels of alginate and sodium carboxymethyl cellulose for colorectal cancer treatment

In this system, methotrexate loaded CaCO ₃ and aspirin are co-entrapped in the hydrogels of alginate and salt carboxymethyl cellulose crosslinked with Ca ² ⁺. Because the pH varies at tiny intestine and colorectum of body, dual pH-responsive shipment of Asp and MTX can be achieved at both body organs, specifically, in response to ambient pH.

Source link: https://pubag.nal.usda.gov/catalog/7415219


Nutritional prevention of colorectal cancer

There is strong evidence that nutritional elements impact CRC risk. An alternative approach for nutritional prevention of CRC is use supplements that give higher specific nutrient exposure than acquired via the diet regimen. There declare data for calcium and/or vitamin D and the n-3 fatty acid EPA from polyp avoidance tests using colorectal adenoma as a CRC threat biomarker. Although CRC is an obesity-related malignancy, there continues to be a paucity of observational information supporting intentional fat burning for CRC risk decrease. Some sorts of obesity surgical procedures may really raise subsequent CRC danger as a result of change of regional intestinal tract elements. Raised mechanistic understanding of the duty of individual nutrients, in addition to a precision medication method to CRC chemoprevention and interception based on both tumor and host elements, should make it possible for translation of nutritional interventions into effective CRC risk reduction steps.

Source link: https://pubag.nal.usda.gov/catalog/7303931


Dendrimer nanoparticles for colorectal cancer applications

Cancer nanotechnology is a respected field of study, where nanotools are utilized to identify and deal with cancer with extraordinary accuracy. Targeted medicine delivery is fundamental for much more reliable cancer treatments. Among all the sort of nanoparticles, dendrimers display numerous advantages, that make them perfect candidates for improved and targeted drug shipment in cancer study. Dendrimers can transport large amounts of medicine into particular areas. Unique emphasis is offered to colorectal cancer and to the recommended utilized approaches for creating drug-loaded/functionalized NPs for cancer therapy in the previous few years.

Source link: https://pubag.nal.usda.gov/catalog/6838974


Histological characteristics, survival pattern and prognostic determinants among colorectal cancer patients in Ethiopia: A retrospective cohort study

In Ethiopia, colorectal cancer is amongst the leading reasons of cancer morbidity and mortality in both sexes. To identify colorectal cancer details survival overtime, we did a Kaplan-Meier survival evaluation and importance of variant in survival across covariates and treatment categories was examined utilizing log-rank test. In the multivariable Cox regression version, the rate of death because of CRC is dramatically higher for patients with elevated standard carcinoembryonic antigen degree, phase IV at medical diagnosis, and mucinous or signet-ring cell cancer histology type. In addition, patients that underwent surgery showed a far better survival than those who did not. In Ethiopia, patients detected with CRC revealed a low rate of cancer-specific survival. Cancer screening programs can help to detect the illness at an earlier phase and to launch offered treatments timely so as to expand the lifespan of CRC patients.

Source link: https://pubag.nal.usda.gov/catalog/7296817

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions