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Colorectal Cancer - PLOS

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Last Updated: 19 July 2022

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Perioperative changes in haemoglobin and ferritin concentrations from preoperative intravenous iron isomaltoside for iron deficiency anaemia in patients with colorectal cancer: A pilot randomised controlled trial

Patients with colorectal cancer are at a high risk of iron deficiency anaemia as a result of chronic tumor-induced blood loss, inadequate diet, or gastrointestinal malabsorption are all common signs. This pilot, double blinded, randomised controlled trial looked at the effect and benefits of using preoperative iron isomaltoside for treating iron deficiency anaemia. Methods: Forty eligible adults with IDA were randomly assigned either intravenous iron isomaltoside or normal preoperative care three weeks before scheduled colorectal surgery. In the iron isomaltoside group, the haemoglobin and ferritin concentrations were higher than the control group during the perioperative period. Mean haemoglobin change from baseline to before surgery was greater in the iron isomaltoside group than the control group, with a significant difference of 6. 1, 95% CI: 0. 1 to 11. 8 g. l-1; P = 0. 040].

Source link: https://doi.org/10.1371/journal.pone.0270640


Quality of life and health status in older adults (≥65 years) up to five years following colorectal cancer treatment: Findings from the ColoREctal Wellbeing (CREW) cohort study

Object: Colorectal cancer is common in older adults, with more than 75% of diagnoses in people aged u226565 years. Here's a look at the five years since CRC treatment, we discover those older people at risk of poor quality of life and health. CREW is a UK longitudinal cohort study looking at factors associated with health and well-being after CRC surgery with curative-intent CRC surgery. Materials and methods: CREW is a UK longitudinal cohort study looking at causes associated with health and wellbeing. Longitudinal studies investigated the prevalence and pre-surgery risk factors of poor QoL and health in older participants over five years. Compared to the youngest-old over sequel, the youngest-old participants reported poorer QoL and 2u20134 times greater chances of experiencing difficulties with mobility or normal activities. Adequate social care has been consistently linked to improved QoL and reduced risk of issues with regular activities and anxiety/depression. Conclusion: During CRC recovery, there are significant differences in QoL and health status for the elderly.

Source link: https://doi.org/10.1371/journal.pone.0270033


Morindone from Morinda citrifolia as a potential antiproliferative agent against colorectal cancer cell lines

In this research, we intend to identify the potential anthraquinone compounds from Morinda citrifolia's root bark to be tested in vitro against colorectal cancer cell lines. According to in vitro tests, morindone and damnacanthal have a significant cytotoxicity effect and selectivity against colorectal cancer cell lines.

Source link: https://doi.org/10.1371/journal.pone.0270970


Ojeok-san ameliorates visceral and somatic nociception in a mouse model of colitis induced colorectal cancer

Often cancer patients and survivors alike, many cancer patients and survivors rely on complementary and alternative medicine to reduce pain and exhaustion. To manage cancer pain, it is therefore imperative to investigate how CAM therapies function as novel analgesics. In this research, we investigated the potential beneficial effects and mechanism of OJS's action in a preclinical model of colitis-associated colorectal cancer. Following OJS treatment, OJS mice were injected into a CT-26 cell viability, dorsal root ganglia activation, and bone-marrow-derived macrophage inflammatory reaction to lipopolysaccharide stimulation. In LPS-stimulated BMDM, OJS has the ability to reduce TNFu03b1 gene expression, according to our in vitro experiments, but no changes were observed in DRG spike number or CT-26 cell proliferation. These results, taken together, indicate that OJS improves nociception in mice and warrants further investigation as a potential CAM therapy to induce analgesia.

Source link: https://doi.org/10.1371/journal.pone.0270338

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions