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Colorectal Cancer - PLOS

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Last Updated: 19 January 2023

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Facilitators and barriers to colorectal cancer screening using the immunochemical faecal occult blood test among an average-risk population in semi-rural Malaysia: A qualitative study

Background: The incidence of colorectal cancer in Malaysia is on the rise, and the majority of CRC patients are diagnosed at a later age. This report looked at participant experiences and views regarding CRC screening, limitations, benefits, and facilitators of CRC screening, as well as health-seeking behavior and the use of preventative health services. Method: Eleven focus group discussions were held in the Segamat District, Johor State, with a targeted sample of 89 people aged > 50 from the major ethnic groups. Conclusions: We found that doctors' trust in doctors was a deciding factor in whether or not to seek health care. Conclusion: Primary care physicians play a vital role in minimizing patient misperceptions, including screening to patients, increasing attendance, and increasing the uptake of CRC screening.

Source link: https://doi.org/10.1371/journal.pone.0279489


High tissue expression of TLRs combined with high density of tumor infiltrating lymphocytes predicts a better prognosis in colorectal cancer patients

Background: Colorectal cancer accounts for 935,000 cancer deaths per year. In CRC, high blood cell infiltration is a contributing prognostic factor. In CRC, we wanted to investigate the correlation between TLR immunoexpressions and T-lymphocyte infiltration densities. Methods: The immune systemically produced TLR2, TLR4, TLR5, and TLR7 positivity and the number of CD3- and CD8-positive cells in tumoral and stromal tissue were examined from the tissue microarray slides of 549 consecutive CRC surgical patients treated at Helsinki University Hospital, Finland, between 1998 and 2005. Conclusions: Positive intratumoral CD3 and CD8 densities were found in studies that follow a high TLR2 signal expression and a high TLR4 signal. Low TLR5 immunoexpression has been shown in association with low intratumoral CD3 and CD8, as well as a low stromal CD3 and CD8 indices. No association or correlation has been established between TLR7 immunoexpression and CD3 or CD8 cell densities.

Source link: https://doi.org/10.1371/journal.pone.0280085


Colorectal cancer screening in Semarang, Indonesia: A multicenter primary health care based study

Colorectal cancer is a significant public health issue in Indonesia. CRC screening in Indonesia has yet to be conducted in primary health care. This cross-sectional analysis was carried out in 10 primary health care centers in Semarang between April to October 2021. The primary test was Immunochromatography Faecal Occult Blood Tests, which was used by the screening process. Patients with a positive I-FOBT result will be sent to Kariadi hospital for colonoscopy and histology examination. The participation rate in the 63% among 37 patients was I-FOBT positive, 37 patients were I-FOBT positive, and 26 patients underwent colonoscopy was 63%. The detection rate of adenoma was 26. 9%. BMI abnormality and family history of malignancy raised the risk of colorectal cancer and adenoma, respectively. I-FOBT positivity in primary health care centers is high. The CRC's screening service focusing on primary care should be considered. To improve colonoscopy proficiency, public awareness should be considered.

Source link: https://doi.org/10.1371/journal.pone.0279570

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions