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Colorectal Cancer - Europe PMC

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Last Updated: 19 August 2022

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Crosstalk between PI3K/Akt and Wnt/β-catenin pathways promote colorectal cancer progression regardless of mutational status.

Bioinformatic analysis revealed the relationship between the mutational status and the clinicopathological characteristics of PI3K/Akt and Wnt/u03b2-catenin pathways, prompting tumourigenic risk in vitro, while in CRC cell models using IGF-1 and Wnt3a treatments. These pathways did not influence CRC patients' survival, but there was no association between clinicopathological characteristics in one patient with mutations in another, but not in both directions. Our results reveal that regardless of mutational status, there exists an interplay between the functions of PI3K/Akt and Wnt/u03b2-catenin pathways that contribute to CRC deaths, and that the reversal of such cases using a PI3K inhibitor highlights the importance of targeting these pathways for future directed therapies in CRC patients.

Source link: https://europepmc.org/article/MED/35944058


Colorectal cancer chemoprevention: is aspirin still in the game?

The use of chemoprevention agents is another method that has been used to minimize CRC exposure. The incidence of adenomas and colorectal cancers has reduced, according to several retrospective studies, as well as a follow-up of large cohorts from primary cardiovascular endpoints. The United States Preventive Services Task Force is now recommending aspirin for primary prevention of CRC in all patients aged 50 to 59 with a 10-y risk of cardiovascular events greater than 10%. In addition, several studies have shown that long-term aspirin therapy after CRC resection reduces recurrence risk and increases overall survival, particularly in patients with PIK3CA-mutated tumors. This paper reviews current research on the pathophysiologic mechanisms of aspirin chemoprevention, discusses the primary clinical findings on CRC prevention and highlights the potential biomarkers that can predict aspirin safety.

Source link: https://europepmc.org/article/MED/35905195


CAFs-derived small extracellular vesicles circN4BP2L2 promotes proliferation and metastasis of colorectal cancer via miR-664b-3p/HMGB3 pathway.

circN4BP2L2's latest studies has revealed that colorectal cancer progression was boosted by circN4BP2L2L2. Cell and normal fibroblast cells of CRC tissues and adjacent tissues were isolated from CRC tissues and adjacent tissues, respectively. Tube manufacture assay was determined by tube construction assay. Double-luciferase reporter detection established the target relationships between circN4BP2L2 and miR-664b-3p, and miR-664b-3p and HMGB3, as well as HMGB3 and HMGB3 were confirmed by dual-luciferase reporter detection. In nude mice, the effect of CAFs-derived sEV circn4BP2L2 on CRC was even investigated. Moreover, CAFs-sEV's knockdown has reduced subcutaneous tumorigenesis and liver metastasis of nude mice with CRC. By regulating the miR-664b-3p/HMGB3 route, CAFsEV circN4l2 knockdown interrupted CRC cell proliferation and migration by limiting the CAFs-sEV route, which culminated in a diluted CRC cell proliferation and migration.

Source link: https://europepmc.org/article/MED/35722996


A comparative study of carbonic anhydrase activity in lymphocytes from colorectal cancer tissues and adjacent healthy counterparts.

On the other hand, cancer and the immune system are inextricably linked, and targeting the immune checkpoints has been shown to successfully treat malignancies. According to the immunosurveillance hypothesis, we have investigated the expression of CA isoforms in tumor-infiltrating lymphocytes, which, according to the immunosurveillance approach, may have played a key role in the formation of colorectal cancer. CA activity was higher in the case of patients with elevated tumour and peripheral blood.

Source link: https://europepmc.org/article/MED/35695123


Cardamonin suppressed the migration, invasion, epithelial mesenchymal transition (EMT) and lung metastasis of colorectal cancer cells by down-regulating ADRB2 expression.

Context Cardamonin can inhibit cell formation in colorectal cancer, a common digestive malignancy. Objectives We investigated the effect and mechanism of CDN on metastatic CRC. Cell viability, migration, and invasion were determined by cell counting kit-8, wound healing, and transwell assays, respectively. At 10 bcmol/L, inhibited MMP-2, MMP-9, and N-cadherin expression, but promotes E-cadherin expression in CRC cells, but at 10 bcmol/L. In addition, ADRB2 overexpression reversed CDN's inhibiting role on metastatic lung nodules. CDN is a potential candidate for the treatment of metastatic CRC in clinical practice, as shown by the study and conclusions.

Source link: https://europepmc.org/article/MED/35645356


A novel tumor-homing TRAIL variant eradicates tumor xenografts of refractory colorectal cancer cells in combination with tumor cell-targeted photodynamic therapy.

Tumor necrosis factor-inducing ligand is a novel device for CRC therapy thanks to its robust and specific apoptosis induction in several CRC cells with MDR. In CRC cells, RGR-TRAIL showed enhanced cell binding and cytotoxicity in comparison to TRAIL. In addition, RGR-TRAIL also promoted tumor formation and growth suppression in mice bearing CRC tumor xenografts. However, TRAIL showed modest tumor growth inhibition under the same conditions, indicating that RGR fusion had a major effect on the anti-tumor activity of TRAIL in DR-overexpressing CRC cells by increasing tumor homing. Nonetheless, RGR-fusion did not significantly raise the antitumor activity of TRAIL in HT29 cells with low adherence to DR. We found that DR expression in HT29 cells with low levels of DR.

Source link: https://europepmc.org/article/MED/35635308


Phototherapeutic effect of transformable peptides containing pheophorbide a on colorectal cancer.

After attaching to the tumor cell surface with the help of the peptide KLVFF, a photosensitizer connected to a receptor-mediated smart peptide can self-assemble into nanoparticles under the force of hydrophobic interaction and then transform into a nanofibrillar network. The photosensitizer on tumors' PDT and PTT characteristics were greatly affected by the supramolecular structure modifications. This self-assembly scheme demonstrated the ability of supramolecular nanofibrils to increase the bioavailability of photosensitizers, opening a new potential treatment avenue for various cancer therapies.

Source link: https://europepmc.org/article/MED/35612320


GSDMD-dependent pyroptotic induction by a multivalent CXCR4-targeted nanotoxin blocks colorectal cancer metastases.

Colorectal cancer remains the third cause of cancer-related death in Western countries, in Western countries, metastases are the primary cause of death. We have developed the T22-PE24-H6 therapeutic protein-only nanoparticle that incorporates the exotoxin A from Pseudomonas aeruginosa to selectively target CRC cells because of its multivalent ligand display that results in a high selectivity interaction with the CXCR4 receptor overexpressed on the surface of CRC stem cells. In a subcutaneous CXCR4+ CRC model, as well as by pyroptotic activation, we found that repeated doses of T22-PE24-H6 reduce tumor formation in a subcutaneous CXCR4+CRC model. For the first time, a targeted drug delivery strategy in CRC models supports the selective deletion of CXCR4+ cancer stem cells, which are associated with resistance, metastases, and anti-apoptotic upregulation.

Source link: https://europepmc.org/article/MED/35532120


Feasibility of implementing project Buhay: the first colorectal cancer screening promotion programme for Filipinos in Alaska.

This report evaluated the possibility of implementing Project Buhay, the first colorectal cancer screening service for Filipinos in Alaska that was developed through a university-community partnership, and determined through university-community cooperation. The PB was piloting two interventions, one of a group health education intervention and a video-based intervention involving a Filipina from Alaska with CRC. Participants in three-month post-intervention, with 80 percent of participants predicting their intention to perform CRC screening within a year. Both the Filipino community in Alaska and the project team's project manager all had positive results at the end of the project, underlining the benefits of university-community collaboration.

Source link: https://europepmc.org/article/MED/35356871


A new self-understanding as chemo sufferer - a phenomenological study of everyday life with chemotherapy induced neuropathy among survivors after colorectal cancer.

Objectives: To investigate the primary meaning of how sensory disturbances induced by Oxaliplatin influence self-understanding and the ability to live an everyday life among survivors of colorectal cancer survivors. Methods Data was generated by a semi-structured individual interview with eight survivors of colorectal cancer who continued to suffer chemotherapy-induced peripheral neuropathy after completing chemotherapy with Oxaliplatin for at least one year. Despite being cured of their cancer disease, the survivors were able to avoid the sensory disturbances by distraction, but survivors were pushed to adjust to a new self-understanding as sufferers after chemotherapy. However, participants' normal routine and life were characterized as an ill health condition, which limited their ability to do everyday activities as well as their ability to fulfill their potential-"I can. "I can" is the participant's response.

Source link: https://europepmc.org/article/MED/35315728

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions