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Colorectal Cancer - Europe PMC

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Last Updated: 19 January 2023

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High endothelial venules proportion in tertiary lymphoid structure is a prognostic marker and correlated with anti-tumor immune microenvironment in colorectal cancer.

However, because HEVs are embedded in TLS, there have been no studies into the role of the HEV proportion in TLS. By the average area of HEV/TLS, the positive HEV expression group was further divided into the high HEV/TLS group and the low HEV/TLS group. Patients with a high HEV/TLS in CRC tissue were prone to longer OS, DFS, and a lower TNM stage. In contrast, CRC tissue with a high HEV/TLS showed a greater ability to recruit the CD3+ T cells, CD8+ T cells, and M1 macrophages, which were correlated with less angiogenesis. High HEV/TLS has been attributed to CRC patients' improved prognosis and inflammation of anti-tumor immune microenvironment, which may be a potential biomarker for CRC patients' prognosis.

Source link: https://europepmc.org/article/MED/36503344


The Rising Incidence of Early-Onset Colorectal Cancer in Germany.

Background In several high-income countries, the incidence of early-onset colorectal cancer is on the rise. Methods We obtained reports on CRC incidence and mortality from the Centre for Cancer Registry Data and the National Institute of Statistical Information on mortality from the official cause of death registries with high incidence coverage in 1999-2018. To determine time trends for individuals aged 20 to 49, we calculated the average annual percent shifts and the respective 95% confidence intervals. Both sexes' incidence of proximal colon cancer rose in both sexes, while distal colon cancer's incidence remained unchanged. Conclusion The incidence of EO-CRC in Germany is on the rise.

Source link: https://europepmc.org/article/MED/36471648


People with early-onset colorectal cancer describe primary care barriers to timely diagnosis: a mixed-methods study of web-based patient reports in the United Kingdom, Australia and New Zealand.

People with early-onset colorectal cancer in children under the age of 50 are more likely to experience diagnostic delay and illness at later stages of the disease than older people. Patient experience reports are increasingly accessible as rich sources of patient experience data. This research explores patients' experiences of early-onset colorectal cancer diagnosis on several bowel cancer support pages in the United Kingdom, Australia, and New Zealand using mixed methods, including quantitative content analysis and qualitative thematic analysis. Patients' perceptions of diagnostic difficulties at the primary care level were similar across the three countries. Patients said that their GPs were unaware of early-onset colorectal cancer and that they were not offering colorectal cancer screening even though'red flag' signs were present.

Source link: https://europepmc.org/article/MED/36641420


Flat clathrin lattices are linked to metastatic potential in colorectal cancer

Among these are flat clathrin lattices and other clathrin lattice structures that have been found in specific cell types, including cancer cells. By combining cell models representative of CRC metastasis with advanced fluorescence imaging and analysis, we discovered that the metastatic promise of CRC is related to an aberrant membranous clathrin distribution, resulting in a higher incidence of FCLs in cells with a higher metastatic potential.

Source link: https://europepmc.org/article/PPR/PPR596613


A novel molecular analysis approach in colorectal cancer suggests new treatment opportunities

Colorectal cancer is a pigmented and clinically heterogeneous disease. The Colorectal Cancer Subtyping Consortium categorized CRC into four specific molecular subtypes in 2015, but this CMS have had no effect on clinical practice. To this end, gene expression and clinical results of 805 CRC samples from three databases were analyzed. Patients were divided into high and low adhesion groups, with prognostic value. According to the expression of immune-related genes, the immune layer divided patients into immune-high and immune-low groups. The molecular layer of four molecular groups related to stem cells, metabolism, Wnt signalling pathway, and extracellular functions. Immune-positive patients with a higher frequency of immune-related genes and genes involved in viral mimicry response may have a benefit for immunotherapy and viral mimicry-related therapies. Consequently, this updated CRC classification may be useful in discovering new therapeutic goals and specific therapeutic approaches in CRC disease.

Source link: https://europepmc.org/article/PPR/PPR596588


Circ-ERBB2 knockdown sensitized colorectal cancer cells to 5-FU via miR-181a-5p/PTEN/Akt pathway.

Colorectal cancer is the fourth most fatal cancer worldwide, and drug resistance hinders treatment of CRC. The impact of miR-181a-5p on CRC cells was contrary to circ-ERBB2, miR-181a-5p downregulation ended the function of circ-ERBB2 silencing in CRC cells, according to miR-181a-5p. Circ-ERBB2 silencing has significantly reduced CRC cell resistance to 5-FU. MiR-181a-5p downregulation outlawed the role of circ-ERBB2 knockdown in CRC cell resistance to 5-FU, which was halted at 5-FU. In conclusion, circ-ERBB2 upregulation promoted CRC's malignancy and reduced CRC cell resistance to 5-FU. In addition, another mechanism research revealed a new regulatory pathway that connected Cir-ERBB2 knockdown, raising the CRC cell sensitivity to 5-FU by regulating the miR-181a-5p/PTEN/Akt pathway.

Source link: https://europepmc.org/article/MED/36639866


NCK-associated protein 1 regulates metastasis and is a novel prognostic marker for colorectal cancer.

In the blood RNA of patient-derived xenograft models of colon cancer, we found that NCK-associated protein 1 was greatly elevated. There was a reduced wound healing area in the NCKAP1 gene knockdown-induced human colon cancer cell lines HCT116 and HT29, as well as significant migration and invasion. Metastasis was limited by NCKAP1 gene knockdown in HCT116 cells, triggering TGFu03b21, but there was also an increase in CTNNB1 expression and reduced FN numbers in HCT116 cells, which was triggered by migration inhibition. We established metastasis models for colon cancer to liver transplantation by intrasplenic injection shRNA of NCKAP1-transfected HCT116 cells or transplanting tumor tissue from the cells cultured in a cecal pouch. Tumor formation and liver metastasis were markedly reduced in metastasis xenograft models.

Source link: https://europepmc.org/article/MED/36639705


Soluble PD-L1: a potential dynamic predictive biomarker for immunotherapy in patients with proficient mismatch repair colorectal cancer.

Background Circulating soluble programmed death ligand 1 can negatively influence T-cell metabolism and act as a prognostic or predictive marker in a variety of cancers. Methods CRC Patients were used to calculate correlations between clinicopathological signs and sPD-L1, undeceived PD-L1 and exosomal PD-L1. In 55 patients with metastatic CRC treated with chemotherapy u00b1-target therapy and 40 patients with effective mismatch repair mCRC treated with combination immunotherapy, the baseline and posttreatment sPD-L1 levels were also investigated. Patients with distant metastasis were found with sPD-L1 in patients with distant lymph node metastasis and tissue combined positive score rather than tumor proportion score. Conclusions sPD-L1 mainly consisted of secPD-L1, and its prevalence was higher in patients with distant metastasis, particularly distant lymph node metastasis and positive CPS.

Source link: https://europepmc.org/article/MED/36639643


The prevalence of back pain in patients operated on due to colorectal cancer depending on the type of surgical procedure performed

Purpose: Low back pain is a significant problem for a variety of medical specialties. Depending on the type of surgery that was performed, the aim of this research was to determine impairment due to low back pain in patients treated for colorectal cancer. Patients with colorectal cancer for scheduled surgeries, including anterior resection of the rectum, laparoscopic anterior resection of the rectum, Hartmann u2019s procedure, or abdominoperineal resection of rectum were among the research subjects included in the study. Conclusions of the study report indicate that low back pain contributes to patient recovery from colorectal cancer surgery, regardless of the type of procedure performed. One year after the surgery in patients with undergone LAR, there was a decrease in the degree of disability due to low back pain.

Source link: https://europepmc.org/article/PPR/PPR596197


Phase Ib/II Trial of BRAF and EGFR inhibition in BRAFV600E metastatic colorectal cancer and other cancers: EVICT (Erlotinib and Vemurafenib In Combination Trial).

BRAF V600E mutant metastatic colorectal cancer makes up a significant healthcare issue, with combination therapy involving oral BRAF inhibitors and EGFR-tageting antibodies being developed clinically in conjunction with EGFR-tageting antibodies. Although promising preclinical results have shown the effectiveness of combination therapy with vemurafenib and small-molecule EGFR inhibitors, gefitinib, or erlotinib in CRC, this therapeutic approach has not been tested in clinical studies. Patients with BRAF V600E positive metastatic colorectal cancer and seven patients with other cancers were enrolled. Overall response rates for 31 evaluable patients with mCRC and 7 with other cancers were 32% and 43 percent respectively, with clinical benefit rates of 65% and 100% respectively. Early ctDNA evolution associated with acquired treatment resistance was established, with regular emergence of MAPK pathway modifications such as polyclonal KRAS, NRAS, and MET amplification.

Source link: https://europepmc.org/article/MED/36638198

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions