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Colorectal Cancer - Crossref

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Last Updated: 19 January 2023

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Association of CCR5Δ32 Deletion and Human Cytomegalovirus Infection With Colorectal Cancer in Tunisia

Tunisia's research sought to determine the relationship between CCR5u039432 genetic deletion and/or HCMV virus infection with CRC. Experiments were conducted on 40 tumor and 35 peri-tumor tissues, 100 blood from CRC patients, and 140 blood samples from 80 healthy subjects with CRC and 100 healthy people. The titers of IgG and IgM antiCMV antibodies in CRC patients were significantly higher than those in healthy controls, and in healthy controls. Conclusion: Our findings revealed that the HCMV infection was linked to CRC birth and that CRC cells could be more infected with HCMV. Given the importance of the CCR5 in inflammation and therefore CRC progression, further research is still required to assess CCR5's role as a potential candidate gene for CRC susceptibility under other polymorphisms.

Source link: https://doi.org/10.3389/fgene.2021.598635


Oral antibiotic use and early-onset colorectal cancer: findings from a case-control study using a national clinical database

This research will determine if an association exists between antibiotic use and early-onset colorectal cancer in early-onset colorectal cancer, as well as in later-onset CRC for comparison. Adjusting for comorbidities, conditional logistic regression was used to calculate odds ratios and 95% confidence intervals for the correlation between antibiotic exposure and CRC by tumour location. 0 u00b7018; u226550 years u226 years y. p = 0u00b7018; p = 0u00b7018; p = 0u00b7018; r = 0 0u00b7018; p = 0u226550 years bp> In both age groups and colon cancer in both age groups, particularly in the early-onset CRC cohort 0 a u00b7018 u22654 years u226550 years yu22654; Conclusions Our results show that antibiotics may play a role in colon tumor formation in both age groups.

Source link: https://doi.org/10.1038/s41416-021-01665-7


Combined Treatment with Immunotherapy-Based Strategies for MSS Metastatic Colorectal Cancer

Effective immunotherapies have revolutionized multiple cancer models in recent years, as a result of increasing understanding of the intricate interactions between the immune system and cancer cells. However, colorectal cancer is one of the tumor forms in which immunotherapy has been less effective. To develop predictive biomarkers and effective therapeutic blend strategies, it's necessary to define the molecular mechanisms for immunogenicity in mCRC and mediating immune dysfunction in MSS mCRC.

Source link: https://doi.org/10.3390/cancers13246311


Reported mortality for colorectal cancer in Brazil in the first 16 years of the 21st century

Introduction: Colorectal cancer is a malignant neoplasm with a major effect on health today. During the first 16 years of the 21st century, the aim is to determine the mortality prevalence and economic cost of CRC in Brazil. Method: Based on the Brazilian Ministry of Health's Mortality Information System database, a retrospective, temporal aggregation study was conducted on CRC mortality from 2000 to 2016. Conclusion: In the study period, mortality related to CRC has increased in mortality.

Source link: https://doi.org/10.22491/2357-9730.93465


Long term follow-up of colorectal cancer screening attendees identifies differences in Phascolarctobacterium spp. using 16S rRNA and metagenome sequencing

Background: In cross sectional studies, the microbiome has been implicated in the onset and progression of colorectal cancer. Methods: We analyzed 144 archived faecal samples from participants in the NORwegian Colorectal CAncer Prevention trial, which was diagnosed with CRC or high-risk adenomas at screening, or who stayed cancer-free during 17 years of follow-up. All samples were tested by 16S rRNA sequencing, as well as metagenome sequencing on a subset of 47 samples. In both the 16S and metagenome results, Phascolarctobacterium succinatutens was more prevalent in CRC than in healthy controls. Bifidobacterium and Lachnospiraceae spp. are present in the spp.

Source link: https://doi.org/10.1101/2023.01.16.23284614


Rates of Follow-up Colonoscopy After a Positive Stool-Based Screening Test Result for Colorectal Cancer Among Health Care Organizations in the US, 2017-2020

FU-CY rates after a promising SBT study to determine the relationship of the early COVID-19 pandemic with FU-CY rates was unclear. The study included records from average-risk primary care patients aged 50 to 75 years with a positive SBT result between January 1, 2017, and June 30, 2020, at 39 HCOs. Patient age, sex, race, ethnicity, insurance type, Charlson Comorbidity Index, and prior SBT use were all typical findings, including prior SBT use. Conclusions and Relevance This report found that after a positive SBT test for colorectal cancer screening in an average risk group, FU-CY rates fell among an average risk group, with the median HCO showing a 54. 4 percent FU-CY rate within 1 year.

Source link: https://doi.org/10.1001/jamanetworkopen.2022.51384


Multicentric study for estimation of prevalence of microsatellite instability and Lynch syndrome amongst colorectal cancer patients in India

Methods We prospectively recruited 207 unrelated patients with CRC from whom primary tumor biopsy was performed as well as a matched blood sample were obtained. A sequential genetic testing strategy for Lynch syndrome diagnosis in colorectal cancer patients in accordance with the UK National Institute of Health and Care Excellenceu2019s National Institute of Health and Care Excellence's guideline was used. Patients had tumours in the descending colon or rectum, according to a median age of cancer diagnosis in the cohort of 52. 3 years, with male to female ratios of 2:1 and 57. 3%. In 79 patients and families with 79 patients, MSI-high status was inversely related to age OR = 0. 95, 95% CI = 0. 92u20130. 97, p = T in the MLH1 gene was most commonly found across Lynch syndrome patients in our cohort. The research reveals a unique opportunity to investigate the development of novel Lynch syndrome detection and cancer prevention in Indian healthcare organizations.

Source link: https://doi.org/10.21203/rs.3.rs-2361537/v1


Knowledge, Attitude, And Practice Towards Colorectal Cancer Screening Among Primary Health Care Physicians In Buraydah, Qassim, Saudi Arabia.

Colorectal cancer is one of the most common cancers worldwide. The knowledge of primary health care physicians regarding colorectal cancer screening is vital in the early detection of cancer and prompt therapy. According to this report, it was designed to investigate PHPs working at primary health care centers in Buraydah, Qassim, Saudi Arabia, and their attitudes, practices, and knowledge. Using SPSS version 21. 0, data was analyzed. The study included a total of 110 primary care physicians. 7. 93 / 3. 39 The mean knowledge score was 6. 93 out of 13. 93;>u00b1 3. 39. U00b1 4. 02 4. 2 percent The mean score in the attitude domain was 10. 58 u00b1 4. 02. Around three-quarters of the physicians' screening will begin at the age of 45 years old. Despite having a positive attitude towards CRC screening, physicians in Buraydah's primary health care centers were deficient in education, which may have an adverse effect on their practices.

Source link: https://doi.org/10.56600/jwmdc.v1i3.26


Remodeling of the Gut Microbiota in Colorectal Cancer and its Association with Obesity

Obesity and colorectal cancer are both showing a positive correlation. There are already strong links between obesity and colorectal cancer. Sequencing studies have shown an altered composition and ecology of intestinal microorganisms in both colorectal cancer and obese patients, as well as identifying certain bacteria as the key role players. The aim of this article is to provide a general idea of how gut microbiota can influence the onset and promotion of colorectal cancer, as well as potential connections between gut microbiota and obesity.

Source link: https://doi.org/10.2174/1381612829666230118123018


Anticancer Potentiality of Ferula assa-foetida Gum Extract against CT-26, HT-29, SW742 and WiDr Colorectal Cancer Cell Lines

Origins: Ferula-foetida L has several therapeutic properties, such as anticancer characteristics. The aim of this research was to determine the anticancer effects of Ferula assa-foetida gum alcoholic extract in CT-26, HT-29, SW742, and WiDr colorectal cancer cell lines. Using MTT assay was applied to several cell lines cultured in DMEM medium and in vitro anticancer effects. Gas and mass chromatography revealed the key phytochemicals present in the gum extract, as well as other chromatography. The gum extract was used on the SW742 cell line, and it was applied to the gum extract on the SW742 cell line. Conclusion: the viability of all tested colorectal adenocarcinoma cell lines, including SW742, CT-26, HT-29, and WiDr lines, depends on the time and concentration of the applied extract of F. assa-foetida gum. A large number of anticancer compounds that were present within the gum extract support the idea of purifying these components and using them in cancer drugs and phytochemistry.

Source link: https://doi.org/10.36346/sarjbab.2023.v05i01.001

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions