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Colorectal Cancer - Astrophysics Data System

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Last Updated: 19 July 2022

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Spatiotemporal regulation of clonogenicity in colorectal cancer xenografts

Colorectal cancer is a heterogeneous disorder with significant variations in genotype and phenotype within each individual tumor. To investigate CRC's growth mode, we used lineage-tracing experiments of human CRC cells transplanted into immunocompromised mice, as well as computational modeling. Tumor formation is influenced by genetic composition, environmental, and tumor geometry.

Source link: https://ui.adsabs.harvard.edu/abs/2019PNAS..116.6140V/abstract


Only three driver gene mutations are required for the development of lung and colorectal cancers

Since the seminal research of Armitage and Doll, one of the key issues in cancer research has been the number of driver events needed for human tumorigenesis.

Source link: https://ui.adsabs.harvard.edu/abs/2015PNAS..112..118T/abstract


Mathematical model of colorectal cancer initiation

We produce and analyze a stochastic model of malignant change in the colon that precisely quantifies the process of colorectal carcinogenesis in patients by loss of tumor suppressors APC and TP53, as well as the KRAS oncogene. We determine the likelihood of a colorectal malignancy, the sizes of premalignant lesions, and the order of gene mutation acquisition during colorectal tumor evolution.

Source link: https://ui.adsabs.harvard.edu/abs/2020PNAS..11720681P/abstract


Engineered colorectal cancer tissue recapitulates key attributes of a patient-derived xenograft tumor line

Understanding tumor biology is the advancement of tumor biology. The development of physiologically appropriate in vitro colorectal cancer models is vital in improving understanding tumor biology. Although CRC patient-derived xenografts recapitulate key patient tumor characteristics and have high concordance with clinical findings, the use of this in vivo procedure is costly and low-throughput. The isolated cells were embedded in PEG-fibrinogen hydrogels, and they were expanded in vivo, dissociated, and embedded in PEG-fibrinogen hydrogels. Tumor cell subpopulations, including human and mouse stromal cells, are maintained in long-term culture; cellular subpopulations increase ratiometrically over time. On day 22, cells in the 3D-eCRC-PDX tissues produced nearly 57% of proteins, which were also present in the CRC-PDX tumors.

Source link: https://ui.adsabs.harvard.edu/abs/2022BioFa..14d5001H/abstract


HunCRC: annotated pathological slides to enhance deep learning applications in colorectal cancer screening

Histopathology is the gold standard for staging and grading human tumors, and it provides important information for the oncoteam's decision making. For careful microscopic examination of the slides made from biopsy tissue samples, highly-trained pathologists are required. A pathologist shortage can often affect healthcare organizations that are often in need of a reliable decision support system. Pathological slides can be digitalized in a high-resolution digital form thanks to recent advancements in digital pathology that have enabled for the pathological slide's high-resolution digitalization. A single patch is a 512 pixel photo of a 512 pixel image covering 248 square meters of tissue area, which is 512 pixels wide. u00d7 248 pixels. u03bcm 2 tissue area: 512 pixels, 512 pixels A single patch is a 512 pixel picture from a single patch. Hopefully, HunCRC, this widely available database will continue to support future colorectal cancer computer-aided diagnosis and study.

Source link: https://ui.adsabs.harvard.edu/abs/2022NatSD...9..370P/abstract


MiWEndo: Evaluation of a Microwave Colonoscopy Algorithm for Early Colorectal Cancer Detection in Ex Vivo Human Colon Models

This report investigates the effectiveness of detecting colorectal cancer precursors or polyps in an ex vivo human colonization model using a microwave colonoscopy technique. With conventional colonoscopy, 22% of polyps go undetected, and the risk of cancer after a negative colonoscopy can be up to 7. 9%. We invented a microwave colonoscopy unit that consisted of a cylindrical ring-shaped switchable microwave antenna array that can be attached to a standard colonoscope's tip as an accessory. With the microwave-assisted colonoscopy device mimicing a real colonoscopy dig, fifteen ex vivo freshly excised human colons with cancer or polyps were examined.

Source link: https://ui.adsabs.harvard.edu/abs/2022Senso..22.4902G/abstract


Decision Programming for optimizing the Finnish Colorectal Cancer Screening Program

Colorectal cancer incidence rates in Finland have steadily risen over the last decade, and CRC is the sixth most common cause of death in Finland. The CRC is a vital concern for Finland's public health. With Decision Programming, a novel approach to solving complex multi-stage decision problems under uncertainty, we optimize the faecal immunochemical test cut-off level for selected target populations with respect to minimization of cancer incidences.

Source link: https://ui.adsabs.harvard.edu/abs/2022arXiv220613830N/abstract

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions