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Langerhans cell histiocytosis is a rare disease that is characterized by the proliferation of Langerhans-type cells that express CD1a, Langerin, and S100 proteins. LCH provides a broad medical spectrum, ranging from single lesions of a single site to multiple or disseminated multisystemic lesions, which can cause severe organ dysfunction. Gastrointestinal tract involvement is rare and has been attributed to systemic disease and poor prognosis, particularly in children under the age of 2 years. Adult gastrointestinal LCH is extremely unusual. Two histologically confirmed hyperplastic polyps at the sigmoid colony were discovered two histologically confirming hyperplastic polyps at the sigmoid colony. There were no other LCH lesions to see. A submucosal 0. 5 cm infiltrated and ulcerated LCH polyp in the cecum, close to the appendix's ostium. On histology all lesions demonstrated typical LCH characteristics, while immunohistochemical testing revealed strong and diffuse staining for CD1a and CD207.
Source link: https://doi.org/10.4322/acr.%y.58875
The impact of training modules on the characterization of diminutive colonic polyps has differing findings. Aim We investigated the effects of a new web-based training module on the accuracy of in vivo characterization of DCPs using various imaging techniques. Methods In an online test module, there were 90 photographs of 30 DCPs seen with high definition white light, i-Scan, and indigo carmine chromoendoscopy. With HDWL and chromoendoscopy, post-training fidelity was much higher than with i-Scan. The percentage of high confidence forecasts increased from 25. 7 percent to 41. 5 percent, with a high confidence prediction accuracy of 81. 7 %. Conclusions In vivo characterization of DCPs are not developed by endoscopic expertise alone. The novel web-based training intervention resulted in modest improvement in accuracy, but further improvements are expected to necessitate more extensive training.
Source link: https://doi.org/10.1055/a-0751-2613
Several prospective studies have been published to determine the fidelity of i-Scan in distinguishing colonic neoplasms from non-neoplasms. Our aim was to perform a meta-analysis of published results to determine the diagnostic accuracy of i-Scan for colonic polyps diagnosis by optical examination of colonic polyps. The AUC of 0. 97 is a result of a study that found polyps histology in real-time in 11 studies. The summary sensitivity and specificity of polyps histology in real-time were 99. 5 percent and 92. 1%, respectively. For three specific diagnostic criteria, the sensitivity was 86. 3%, 93. 0%, 85. 0%, respectively, and specificity was 84. 8%, 91. 8%, respectively.
Source link: https://doi.org/10.1371/journal.pone.0126237
Type 2 diabetes mellitus is a risk of CRC, and metformin reduces CRC risk. Between May 2001 and March 2013, there were studies to see if metformin could influence the incidence of colonic polyps and adenomas in patients with type 2 DM. MethodsOf 12,186 patients with type 2 DM, 3,775 underwent colonoscopy. This investigation included 3,105 of these patients, and divided them into two groups: 912 patients with metformin use and 2,193 patients without metformin use. Results:The colorectal polyp detection rate in the two groups was lower in the metformin group than in the non-meformin group. The colorectal adenoma detection rate in the metformin group was significantly lower than in the non-metformin group. Hence, metformin may be useful in the prevention of CRC in patients with type 2 DM.
Source link: https://doi.org/10.5217/ir.2014.12.2.139
Background/Aim: To determine the prevalence of serrated colorectal polyps in the King AbdulAziz University Hospital population and to review the existing classification of colorectal serrated polyps with a focus on morphological characteristics. Study Conclusions: Diagnosed hyperplastic polyps accounted for 12. 3% of all colorectal polyps submitted to our laboratory during the study period. The most common subtype of the medically diagnosed serrated polyps is the microvesicular serrated polyps. Conclusion: Serrated colorectal polyps in our geographic area seem to be similar to that in western populations.
Hence, this study was intended to look at thyroid nodule prevalence in patients with colonic polyps. Patients with colonic polyps and 146 patients without colonic polyps were enrolled in the study. Patients with colonic polyps were enrolled in a age and sex matched control group. Compared to patients with hyperplastic polyps, patients with adenomatous polyps had 5 or more thyroid nodules. Patients aged 50 to 60 were more prevalent among patients than those who had less than 50 years ago. Patients with colonic polyps were more likely to have thyroid nodules.
Source link: https://doi.org/10.1155/2012/178570
Background Narrow band imaging is an advanced endoscopic imaging method that improves visualization of the mucosal surface and is used as a screening device for colonic polyps. For the analysis of colorectal polyps, we determined the use of the Japan NBI Expert Team classification. Methods An prospective observational study was conducted from January 2018 to June 2019 of patients undergoing colonoscopy at a tertiary care hospital. Histopathology findings were consistent with the pattern of polyps detected by NBI using the JNET classification. The sensitivity was 90%, specificity was 97%, positive predictive value was 97%, and diagnostic accuracy was 96% when comparing our findings with JNET category type 1 and hyperplastic polyps. Conclusion Based on the changes in colonic mucosal characteristics, NBI has a great likelihood to rule out carcinoma possibilities. In colonoscopy, we described NBI's high-diagnostic success in obtaining a clear diagnosis of early colorectal cancers.
Source link: https://doi.org/10.1055/s-0040-1714169
This research sought to determine whether polyps' molecular characteristics might reveal clues about the possibility of metachronous advanced neoplasia. We retrospectively recruited 308 patients with colonic polyps. Patients were divided into three subgroups, based on the polyp mutational profile at baseline, such as non-mutated polyps, at least one BRAF-mutated polyp, or at least one KRAS-mutated polyp. In comparison, advanced serrated polyps were identified as serrated polyps u2265 10 mm in any location, proximal to the splenic flexure of any size or with dysplasia. In contrast, 289 patients could be classified as wild-type, BRAF mutated, or KRAS mutated. Our findings revealed correlations with the onset of advanced neoplasia as a result of genetic variation in polyps and advanced adenomas.
Source link: https://doi.org/10.1371/journal.pone.0184937
It is unclear if the availability of new techniques for removal of large colonic polyps has influenced segmental colon resection. The mean polyp size was 2. 9 cm compared to 2. 9 cm. 97 patients had a polyp that was believed to be unresectable by EMR, and 31 underwent successful EMR, followed by surgery for adenocarcinoma. In 51, the indication for surgical treatment in those with unresectable polyps was variable and was not well documented; only 17 of these patients had a TG; only 17 of these patients had a TG. A significant number of polyps treated by segmental resection did not contain adenocarcinoma.
Source link: https://doi.org/10.1155/2018/7046385
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