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Colonic Polyps - Crossref

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Last Updated: 23 June 2022

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NF-kappa B expression in resected specimen of colonic cancer is higher compared to its expression in inflammatory bowel diseases and polyps

Abstract NF-Kappa B plays a significant role in inflammation processes as well as in colorectal cancer. This research was designed to compare the expression of NF-bappa B in colonic adenocarcinoma specimens, colonic adenomas, and inflammatory colonic tissues. Positive node status was correlated to positive node status in cancer patients. The cancer group had a higher incidence of inflammation, less in the IBD group, and the lowest in the colonic non diseased margins. Our findings show that the NF-u03baB pathway is heavily involved in colon cancer formation and metastasis in colon cancer formation and metastasis. Interestingly, the prevalence of NF-u03baB in benign polypoid lesions was similar to that in inflammatory etiologies. This explains the role of NF-u03baB early in the adenoma to carcinoma transition. In order to search for diagnostic and therapeutic options, further research is needed to establish the precise role of NF-u03baB in tumor progression.

Source link: https://doi.org/10.21203/rs.3.rs-1749050/v1


The Safety of Hot Biopsy Forceps in the Removal of Small Colonic Polyps

With monopolar electrocoagulation forceps, nine hundred and seven polyps from 460 patients were removed from 460 patients. There were three cancers and 1 neurofibroma in this series. Hot biopsy removal of small colonic polyps is safe, according to the guidelines.

Source link: https://doi.org/10.1159/000007592


Risk Factors for Delayed Hemorrhage after Colonic Endoscopic Mucosal Resection in Patients Not on Antithrombotic Therapy: Retrospective Analysis of 3,844 Polyps of 1,660 Patients

Background/Aims: Colonic endoscopic mucosal resection is safe for patients without antithrombotic therapy; however, EMR is associated with various risks. This research was done to determine the possibility of delayed hemorrhage in patients with EMR without antithrombotic therapy. Methods: The Saga Medical Centre Koseikan's retrospective single-center study found 1,792 patients without antithrombotic therapy underwent colonic EMR from March 2012 to December 2016 patients. The hemorrhage was classified as bleeding for which emergency endoscopic hemostasis was applied more than 24 hours after EMR. Delayed hemorrhage affected 43 patients and 46 polyps. According to Univariate results, delayed hemorrhage occurred more often in young patients than in older patients, and was correlated with large polyps, hemoclip, and piedunculated polyps. Conclusion: According to the current report, young age and large polyp size are risk factors for delayed hemorrhage in patients without antithrombotic therapy.

Source link: https://doi.org/10.1159/000494455


Clinical guidance on endoscopic management of colonic polyps in Singapore

Colonoscopy with endoscopic resection of suspected colonic adenomas interrupts the adenoma-carcinoma sequence and reduces the risk of colorectal cancer and cancer-related mortality. An expert research group under the auspices of the Academy of Medicine, Singapore, was established in Singapore to provide advice on colonic polyps endoscopic treatment.

Source link: https://doi.org/10.11622/smedj.2020108


Accuracy of Self-reported Colonic Polyps: Results from the Prostate, Lung, Colorectal, and Ovarian Screening Trial Study of Colonoscopy Utilization

Patients can be held accountable for reporting findings between primary and specialty care or providing medical information to family members, so accurate reporting is critical. Correlates of truth self-report of polyp were determined by logistic regression and weighted to account for study samples. Comparisons: Self-reported polyp findings were 88% and 85%, respectively, and adenom 11% and 99%, respectively, with sensitivity and specificity shown. Older people with a polyp was associated with reduced risk of recall, while polyp severity and non-white race were associated with heightened likelihood of accurate recall. Among those without a polyp, having multiple colonoscopies was correlated with lower risk, although family history of colorectal cancer increased the likelihood of accurate recall. Impact: For patient-u2013provider communications and patient reporting of findings, the most important steps to raise accurate self-report of colonic polyps are required.

Source link: https://doi.org/10.1158/1055-9965.epi-19-0951


MicroRNA Signatures of Colonic Polyps on Screening and Histology

Abstract In an apparent mucosa-to-adenocarcinoma sequence, colorectal cancer and adenoma adjacent to cancer have distinct microRNA modifications. In biopsy specimens from 109 patients undergoing screening/surveillance colonoscopy, normal mucosa, hyperplastic polyps, tubular adenomas, tubular adenomas, or high-grade dysplasia was performed on normal mucosa, hyperplastic polyps, tubular adenomas, tubular adenomas, tubular adenomas, tubular adenomas, or high-se a The false discovery rate was used to control for multiple comparisons. MiR-145 and -619 both provided high accuracy in determining low-risk polyps without serrated histology, whereas miR-144, 143, and -30a demonstrated high success in distinguishing high-risk polyps from low-risk polyps without serrated histology. Our findings point to the presence of colorectal canceru2013-related miRNA mutations in screen-detected adenomas, which may be useful for risk stratification for surveillance interval planning.

Source link: https://doi.org/10.1158/1940-6207.capr-16-0086


A New Biomarker That Predicts Colonic Neoplasia Outcome in Patients with Hyperplastic Colonic Polyps

Hyperplastic polyps, according to new studies, may be precursors to certain sporadic colorectal cancers. We investigated whether its expression in hyperplastic polyps could lead to colon carcinogenesis, and colonic neoplasm follows after resection of hyperplastic polyps. We retrospectively analyzed progastrin expression in hyperplastic polyps from 74 patients with no history of colorectal pathology. Patients with high overexpression of progastrin had a 5-year survival rate of 38 percent, compared to 100% for patients with poor progastrin expression. Progastrin expression testing in hyperplastic polyps is a highly effective prognostic tool to identify patients at a higher risk of metachronous neoplasms that could benefit from a adapted sequel.

Source link: https://doi.org/10.1158/1940-6207.capr-11-0408


Changes in the inflammatory microenvironment in premalignant colonic adenomatous polyps: Evidence for immunosurveillance?

The present research sought to describe the local inflammatory response in pre-malignant colorectal adenomatous polyps. Methods: Patients with adenomatous polyps removed at colonoscopy as part of a population FOBt screening service were identified from a prospectively maintained database. The findings of inflammatory cell infiltrate were acceptable or better for CD3+, CD8+, and CD68+ staining. Patients in the HG and LG polyps groups were both older and female in the HG group compared to HG and LG polyps. HG polyps were more likely to have a villous component than LG polyps. HG polyps were elevated in both CD3 + and CD8+ infiltrate, relative to LG polyps. An increase in local T-lymphocyte infiltrate, but not macrophage infiltrate, was discovered with a shift from low-grade to high-grade dysplasia.

Source link: https://doi.org/10.1200/jco.2015.33.3_suppl.535


Hypoalbuminaemia and colonic polyps: a case of protein-losing enteropathy with cap polyposis?

Several pedunculated polyps up to the splenic flexure were found, with histology appearing to be consistent with hyperplastic polyps and mild inflammation. However, the bowel preparation made her feel ill. The patient appeared pale and dehydrated. Bloods revealed a corrected calcium of 1. 58 mmol/litre. A low albumin of 21 g/litre was detected in liver function tests, but they were otherwise unremarkable. A gastroscopy revealed mild oesophagitis with Candida in the mid- and lower oesophagus, gastritis in the stomach's antrum, with heavy Helicobacter pylori growth and a normal duodenum. A 24-hour urine protein sample was 0. 46 g, excluding nephrotic syndrome. A modestly elevated chromogranin A and gastrin were found in the gut hormones, but not indicative of a neuroendocrine tumor. Amyloid was interrogated and the original colonic biopsies were reexamined. Multiple dark sessile polyps, looking like slugs, were discovered on exaggerated mucosal folds in the distal large bowel, exposing exaggerated mucosal folds, according to a post mortem. Cap polyposis is a compound of granulation tissue that has been documented as cap polyposis, with evidence of inflammation and a 'cap' of granulation tissue confirming cap polyposis. In addition, the patient had a right haemothorax. The right ventricle was hypertrophic, with multiple haemorrhagic infarcts on the lungs. The patient had been showing pulmonary emboli from a deep vein thrombosis for some time, possibly due to immobility due to her poor state of health. At a post mortem, a right calf DVT was cited to this DVT. The dissection of the pulmonary artery was presumably related to the poor protein state and persistent artery hypertension.

Source link: https://doi.org/10.12968/hmed.2007.68.8.24498


Removal of colonic polyps through endoscopic mucosal resection

Endoscopic mucosal resection is a widely used procedure that is a less invasive alternative to surgical intervention for colonic superficial neoplasms. It is especially useful for removing colonic polyps that are impossible to remove by conventional snare polypectomy. The removal of large colonic polyps during endoscopy has raised a variety of questions, including the possibility of the procedure's risk and the possibility of inadequate polypectomy.

Source link: https://doi.org/10.12968/gasn.2010.8.7.78434

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions