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Colon Cancer - PubMed

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Last Updated: 12 April 2022

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COVID-CCD-Net: COVID-19 and colon cancer diagnosis system with optimized CNN hyperparameters using gradient-based optimizer.

Coronavirus disease-2019 is one of the new forms of coronavirus that have caused pandemic disease in a short time. For the diagnosis of COVID-19 in national healthcare centers, a reverse transcription-polymerase chain reaction test is used. Colorectal cancer is another illness that affects people's lives in a significant way. Tissue microarray is a medical device that is widely used for its high success in the detection of colorectal cancer. In TMA photographs, computer-assisted methods that can distinguish colorectal cancer are also needed. TMAs can also be classified in other aspects, such as epithelial and stromal regions. Even at a time of fright, the experimental results showed that the proposed classification improved the classification results of the non-optimized CNN architectures' classification results significantly, resulting in a high classification result even in a very low value of epoch.

Source link: https://doi.org/10.1007/s11517-022-02553-9


KCNQ1 and lymphovascular invasion are key features in a prognostic classifier for stage II and III colon cancer.

Some patients classified as "low risk" do experience recurrence, while others receiving ACT may not have noticed recurrence at all. We previously reviewed tumor tissue samples for 28 protein biomarkers that may aid in the detection of patients at risk of recurrence.

Source link: https://doi.org/10.1186/s12885-022-09473-9


TRAIL/S-layer/graphene quantum dot nanohybrid enhanced stability and anticancer activity of TRAIL on colon cancer cells.

Since it can selectively induce apoptosis in a variety of cancer cells, Tumor necrosis factor-related apoptosis-inducing ligand, also known as a TNF superfamily cytokine, is considered a promising antitumor drug. MTT assay and flow cytometry confirmed approximately 80% apoptosis in cancer cells, demonstrating the potential anticancere's efficacy of the nanohybrid system on intrinsically resistant cells to TRAIL. These results show that TRAIL is a therapeutic protein that can be significantly enhanced by nanotechnology and introduce the S-TRAIL/GQD complex as a promising nanohybrid system in cancer treatment.

Source link: https://doi.org/10.1038/s41598-022-09660-5


Robot-Assisted Right Colectomy with Sequential Wedge Resection of Segments 4 and 5 of The Liver and Cholecystectomy for Colon Cancer with Metastasis to The Liver.

Because of portal circulation, the liver is the most common site for colon adenocarcinoma metastasis in colon colony. The surgical treatment of patients with colon adenocarcinoma with simultaneous metastasis to the liver has been criticized. The simultaneous resection of a colorectal adenocarcinoma with a liver metastasis has similar outcomes as the traditional staged approach to investigating morbidity, mortality, and long-term oncologic effects.

Source link: https://doi.org/10.1177/00031348221084938


Dark-Lumen Magnetic Resonance Image Based on Artificial Intelligence Algorithm in Differential Diagnosis of Colon Cancer.

The study subjects were limited to a total of 98 patients with ulcerated colon cancer. The detection of colon cancer was compared between the two groups. ADC in the algorithm group was 1. 55 0. 31 mm2/s, with apparent diffusion coefficient in the control group at 0. 92 0. 14 mm2/s. Patients in algorithm group had a significantly higher ADC than those in the control group, with a statistical difference. In comparison, the correct rate in algorithm group was 10% higher than in algorithm group, indicating that the diagnostic effect was greater in algorithm group. In the algorithm group, the mean value of invasion depth was 10. 42 in the algorithm group and 5. 27 in the control group, indicating that the algorithm group was more accurate in the assessment of invasion depth, had a promising track record, and had guiding relevance for colon cancer diagnosis.

Source link: https://doi.org/10.1155/2022/4217573


Newcastle disease virus expressing an angiogenic inhibitor exerts an enhanced therapeutic efficacy in colon cancer model.

Newcastle disease virus-mediated gene therapy is a promising new treatment for cancer treatment, but it does not appear to have high incidences of angiogenesis. In this research, the VEGF-Trap gene was included in the genome of NDV to enhance the anti-tumor effect of NDV. In EA. hy926 cells, the results showed that rNDV-VEGF-Trap reduced cell growth ratio by 85. 3 percent and migration ratio by 87 percent. The number of vascular endothelial cells in the tumor tissues had greatly decreased thanks to rNDV-VEGF-Trap immunohistochemistry research of CD34. Moreover, a Western blot review revealed that therapy with rNDV-VEGF-Trap reduced AKT, ERK1/2, and STAT3 phosphorylation levels of AKT, ERK1/2, and STAT3 significantly, raising the expression levels of P53, BAX, and cleaved caspase-3 in tumor tissue, according to a new analysis. These results show that rNDV-VEGF-Trap has an enhanced inhibition of CT26-bearing mice by raising anti-angiogenesis and apoptosis, and it could be a potential candidate for carcinoma therapy, particularly for colon cancer.

Source link: https://doi.org/10.1371/journal.pone.0264896


Hyperglycemia alters N-glycans on colon cancer cells through increased production of activated monosaccharides.

Diabetes Mellitus is both highly related and a known risk factor for colorectal cancer. Here we use mass spectrometry to decipine the composition and putative structures of N-glycans cultured in normoglycemic and hyperglycemic environments. In MC38 cells cultured in LG and HG, 67 glycans were identified, 67, who were found in MC38 cells cultured in LG and HG. When compared to LNG cells, cells grown in HG showed a higher number of N-glycans than in LNG cells, and without changes in the proportion of sialylated, fucosylated, and mannosylated N-glycans.

Source link: https://doi.org/10.1007/s10719-022-10057-9


Mast cell modulates tumorigenesis caused by repeated bowel inflammation condition in azoxymethane/dextran sodium sulfate-induced colon cancer mouse model.

Mast cells invade the inflammatory microenvironment and regulate the production of several pro-inflammatory cytokines and mediators of inflammation cell manufacture in order to promote tumor formation and intestinal lesions. Currently, there are insufficient studies into the mediators and signaling pathways regulated by mast cells that influence colon cancer pathogenesis in inflamed colon tissue. This research sought to establish mast cells' role in colitis-associated colon cancer's incidence and growth as well as other inflammation-mediated causes and signaling pathways related to tumor formation.

Source link: https://doi.org/10.1016/j.bbrep.2022.101253


Golgi Phosphoprotein 3 Promotes Colon Cancer Cell Metastasis Through STAT3 and Integrin α3 Pathways.

Methods: Using siRNA transfection, in vitro genetic ablation of GOLPH3, was achieved, and a stably overexpressed GOLPH3 colon cancer cell line was constructed using the lentivirus method. Results: GOLPH3 overexpression was detected in CRC tissues and colon cancer cell lines, overexpressing GOLPH3. Following the GOLPH3 knockdown, the phosphorylation level of STAT3 as well as the protein and mRNA levels of ZEB1 and integrin 3 were significantly reduced. Also, Integrin 3 expression in CRC tissues was correlated with GOLPH3 expression. GOLPH3 was involved with pSTAT3 and total STAT3 during the investigation bysay, assay revealed that it was revealed that GOLPH3 interacted with pSTAT3 and total STAT3 assay assay. Conclusion: In colon cancer cells, our latest findings shows that GOLPH3 promotes STAT3 transcription factor ZEB1 and Integrin 3 promotes STAT3 transcription and regulates the expression of EMT transcription factor ZEB1 and Integrin 3 promotes STAT3 transcription factor ZEB1 and Integrin 3-dependent genes. These results indicate that GOLPH3 plays a key role in CRC metastasis and could be a new therapeutic target for CRC therapy.

Source link: https://doi.org/10.3389/fmolb.2022.808152


Search for Key Genes and Functional Pathways of Ulcerative Colitis to Colon Cancer Based on Bioinformatics.

Ulcerative colitis is a chronic and diffuse inflammatory disease of the intestine. About 30% of patients with UC have widespread and aggressive colitis, and they are at a greater risk of colon cancer. The genetic details and potential molecular mechanisms shared between UC and colorectal cancer were investigated in this study. String and Cytoscape were used to analyze the module and find hub genes in a module containing 15 genes. Weighted gene co-expression network analysis was used to find co-expression modules associated with UC and colon cancer, with 52 overlapping genes. Both gene cohorts were tested using the Metascape online tool, with three key functions or pathways associated with both gene cohorts. For the first time, this report shows that CCT2 can be a promoter of UC conversion into colon cancer, as well as finding novel gene candidates that could be used as biomarkers or potential therapeutic goals.

Source link: https://doi.org/10.3389/fonc.2022.857148

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions