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Colon Cancer - Europe PMC

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Last Updated: 19 August 2022

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Development of nanocubosomes co-loaded with dual anticancer agents curcumin and temozolomide for effective Colon cancer therapy.

For safe colon cancer therapy, current research sought to develop nanocubosomes co-loaded with dual anticancer drugs curcumin and temozolomide. Using HCT-116 colon cancer cells, the in-vitro cell-uptake, mode of cell-uptake, in-vitro anti-tumor serum, and apoptosis level were investigated further. U00b1 2. 1 percent and 83. 55 percent u00b1 1. 5 percent, improved drug loading capacity LC of 6. 82 percent and 755 percent, respectively, with virtually cubic shape and high colloidal stability in various physiological mediums. In addition, BSA-stabilized nanocubosomes were mainly taken by aggressive colon cancer cells that over-expressed the albumin receptors and used BSA as a nutrient source for their growth. In short, this report is a new and simple way to raise the efficacy of colon cancer therapy while simultaneously overawsing the adaptive treatment tolerance.

Source link: https://europepmc.org/article/MED/35942514


Oxaliplatin-loaded nanoemulsion containing Teucrium polium L. essential oil induces apoptosis in Colon cancer cell lines through ROS-mediated pathway.

The drug's clinical use of the drug in colon cancer therapy has significantly limited due to Oxaliplatin-associated adverse side effects. Given the p53 profiles of colon cancers, it would be extremely helpful to find an alternative therapeutic approach that does not only minimizes the toxicity of Oxa but also has a synergistic effect against colon cancers. The present research was designed to develop and optimize Teucrium polium L. essential oil nanoemulsion, as well as determining its effect on colon cancer cells' sensitivity with differences in p53 status to Oxa. The colony-forming capacity of treated cells was determined by colony assay. Cells treated with Oxa + TPO-NANO had a higher incidence of apoptosis than cells exposed to monotherapy, according to microscopic examination and flow cytometric analysis. When combined with TPO-NANO, Oxa produced an apoptotic effect on wild or mutant p53 colon cancer cells by a process that involves ROS-mediated mitochondrial apoptosis.

Source link: https://europepmc.org/article/MED/35815706


Gnetum montanum extract induces apoptosis by inhibiting the activation of AKT in SW480 human colon cancer cells.

Objective Objectives: To determine the action and mechanism of G. montanum extract against colon cancer cells, see Chapter 480. Material and methods The in vitro activity of GME on SW480 cells was determined using MTS assays at 24, 48, and 72 h. For 24, 48, and 72 h, respectively, the experiments showed that apoptotic cells and G2M phase cells viability by GME increased from 20. 81 to 61. 5 percent and 54. 3 percent with 120 bcg/mL GME. In vivo experiments, GME appears to have a significant effect on SW480 cell growth and migration in xenograft zebrafish. At 28 mg/day (28. 9%) and to 53. 1 percent at 56 mg/kg/day, GME reduced the nude mouse tumor weight to about 31. 9 percent at 28 mg/kg/day and to 53. 1 percent at 53. 1 percent.

Source link: https://europepmc.org/article/MED/35587342


Aloe gel glucomannan induced colon cancer cell death via mitochondrial damage-driven PINK1/Parkin mitophagy pathway

We found that Aloe gel glucomannan significantly reduced colon cancer cell proliferation. In colon cancer cell line CT26, AGP upregulated autophagy, lysosome, and mitochondrial fission signal pathways, according to RNA-seq analysis. Interestingly, the mitophagy stimulator promoted AGP-induced mitophagy and cytotoxicity in AGP-induced mitophagy and cytotoxicity, whereas the mitophagy inhibitor reversed the effect of AGP. These results, taken together, showed that AGP produced cytotoxic mitophagy in CT26 cells via the ROS-related PINK1/Parkin pathway and TFEB transcription.

Source link: https://europepmc.org/article/MED/IND607826044


Serial Circulating Tumor DNA in Monitoring the Effect of Neoadjuvant and Adjuvant Immunotherapy in Patients With Colon Cancer: Case Series and Review of the Literature.

Although limited, continuous DNA mismatch repair-deficient /microsatellite stability in adjuvant and adjuvant settings are limited in the neoadjuvant and adjuvant setting, programmed death 1 blockade has greatly enhanced the survival of advanced colorectal cancer patients with DNA mismatch repair-deficit reconstruction-deficient /microsatellite instability. We present a case series of three colon patients who underwent and adjuvant immunotherapy as well as serial ctDNA analysis. Mutated colorectal cancer and the role of ctDNA monitoring are both important and metastasis in locally advanced and metastasis in dMMR/MSI-H/POLE mutated colorectal cancer and metastasis. Further research is needed to determine the long-term effiicacy of neoadjuvant and adjuvant programmed death 1 blockade in locally advanced and metastasis in dMMR/MSI-H/MSI-H/H/POLE mutated colorectal cancer in mutated colore mutated colorectDNA mutated coloret ade.

Source link: https://europepmc.org/article/MED/35980372


Expression and Prognostic Significance of Stem Cell Marker CD133 in Survival Rate of Patients with Colon Cancer.

Introduction Today, colon cancer is one of the most common forms of gastrointestinal cancer worldwide. Cell proliferation and differentiation in many tumors, including colon cancer, have been shown by using CD133 as a recognized cancer stem cell marker. By immunohistochemistry, we wanted to investigate the relationship between CD133 gene expression in colon cancer with prognostic factors and the survival rate of patients with colon cancer. Conclusion CD133 is a valuable predictive or prognostic biomarker for CRC in clinical evaluation, and it may be a potential therapeutic target for CRC.

Source link: https://europepmc.org/article/MED/35980560


2D Cu-Bipyridine MOF Nanosheet as an Agent for Colon Cancer Therapy: A Three-in-One Approach for Enhancing Chemodynamic Therapy.

Chemodynamic therapy is a highly tumor-specific and minimally invasive treatment that is commonly used in cancer therapy. Based on three factors, the therapeutic effect of Cu 2 is enhanced. The ultrasmall CuS created after H 2 S depletion aids Fenton-like reactions in second. Both in vitro and in vivo experiments showed that Cu 2 2's ability to enhance the CDT effect. This research demonstrates the applicability of 2D Cu-MOF in colon cancer's CDT and presents a new approach for producing CDT agents for colon cancer.

Source link: https://europepmc.org/article/MED/35979620


Identifying novel interactions of the colon-cancer related APC protein with Wnt-pathway nuclear transcription factors

Identifying novel interactions of APC in the Wnt pathway would help to better understand APC's nuclear function and potentially identify future cancer treatment targets. Methods We used the all-vs-all sequencing scheme to interrogate the interome of protein fragments from most of the 60 Wnt u03b2-catenin pathway proteins. The protein binding regions between the proteins were discovered with greater precision than a full protein approach by using protein fragments. Conclusions Based on our findings of novel interactions between APC and transcription factors, as well as previous reports of APC localizing to the nucleus, we recommend APC will compete and repress CTNNB1. This will happen by transcription factors' binding to control the Wnt signaling pathway, including enhanced marking of CTNNB1 for degradation in the nucleus by APC binding with SOX17. This review's additional novel Wnt b2-catenin pathway protein-protein interactions may lead to novel drug designs for cancer.

Source link: https://europepmc.org/article/PPR/PPR532997


Combinatorial therapeutic approaches of photodynamic therapy and immune checkpoint blockade for colon cancer treatment.

Photodynamic therapy has had dramatic therapeutic effects on various types of cancers by reactive oxygen species generation and induction of immune responses. The photosensitizer indocyanine green, on the other hand, can mediate PDT under near-infrared illumination, thus increasing the penetration depth of the tumor's excitation light. ICG is rapidly taken up in vitro by colorectal MC38 and CT26 tumor cells, which promotes PDT-mediated cell-killing effects. Our findings furthermore showed that ICG causes immunogenic cell death, as dendritic cells were discovered to engulf ICG-treated tumor cells and undergo phenotypic maturation. We wanted to develop a therapy that maximizes tumor control considering the benefits of ICG as a photosensitizer. The combination therapy, relative to a single therapy, resulted in reduced solid tumor formation and raised the survival rate of tumor-bearing mice.

Source link: https://europepmc.org/article/MED/35974207


The Impact of an Enhanced Recovery Protocol in a High-Risk Population Undergoing Colon Cancer Surgery.

Objective Enhanced Recovery ERP systems have improved surgical outcomes in patients undergoing elective colon cancer surgery; however, effectiveness in various populations may vary. We investigated the effect of an ERP in a population with high incidences of obesity and multiple comorbidities. Methods We conducted a retrospective review of factors associated with postoperative complications and length of stay in a 5-hospital healthcare system that serves a population with higher incidences of obesity and multi-comorbidities, as well as published studies. Conclusions A total of 408 elective CC surgery patients with complete oncologic surgical data were identified. Both the non-obese and obese groups had an effect on LOS. Both obese and non-obese patients, as well as non-obese patients, experienced a decrease in LOS. Following CC surgery, optimization of surgical outcomes may be particularly important in high-risk populations.

Source link: https://europepmc.org/article/MED/35969481

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions