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"Abstract High-grade ovarian cancer is highly sensitive to chemotherapy and yet it is often lethal as a result of recurrent disease. " To address the underlying mechanism of chemotherapy resistance in this disease, we used novel technologies developed to clone normal adult epithelial stem cells to produce libraries of patient-specific, clonogenic tumor cells. These intrinsically resistant clones have shared genomic and gene expression profiles with those who have completed pactaxel therapy, revealing a role for intrinsically resistant cells in recurrent disease. Both intrinsically resistant and paclitaxel survivor clones are chemically lethal with standard-of-care chemotherapy, but not in vivor clones. New approaches for preventing recurrent disease can be found in the targeting of intrinsically healthy clones from patient-specific libraries of cancer stem cells. Philadelphia, PA, October 1-4, 2017; Clin Cancer Res 2018:Abstract nr B05; Abstracts from the AACR Conference: Addressing Critical Questions in Ovarian Cancer Research and Treatment; 1-4, 2017; AACR; AACR's 2017: Bethestract B05; AACR; Clin Cancer Res 2018;24:Abstract B05.
Source link: https://doi.org/10.1158/1557-3265.ovca17-b05
"Profilin is a small actin-binding protein that is involved in various aspects, including cell structure stability, cell proliferation, tumor cell metastasis, and growth factor signal transduction. The profilin-3 cDNA encoded 137 amino acids, and it showed significant similarity to profilin-1 and profilin-2 from mice and humans, with profilin-1 and profilin-2. In addition, we found that the expression of profilin-3 mRNA in two types of renal diseases, diabetic nephropathy, and polycystic kidney diseases, was significantly increased in two other forms of renal disease. Profilin-3 was localized in the cytoplasmic domain, similar to profilin-1 and profilin-2. These findings show that, amid to the ubiquitous presence of profilin-1 and profilin-2, there is a tissue-specific form of these cytoskeletal-regulatory proteins, and that the kidney/testerol-specific profilin-3 can play a significant role in renal and/or reproductive functions. ".
Source link: https://doi.org/10.1159/000052621
In AP-16 cells, an astrocyte progenitor-like cell line expressing GLAST, "TGF-u03b2 induced CysC and GFAP expression, indicating GLAST. CysC gene expression appeared in the mouse forebrain earlier than that of GFAP in the mouse forebrain. Although previous research showed that CysC is involved in the growth of adult neural stem cells, our results show that it is involved in astrocyte differentiation during mouse brain development.
Source link: https://doi.org/10.1159/000080714
"Multicasting of quantum states is a fundamental feature of quantum internet. " We explore the multicasting of a single copy of unidentified state over a quantum network that supports free classical communication in this paper. At a source node, two asymmetric optimal clones of an input state are created. The state is divided into classical knowledge and a compressed quantum state, according to Then. "Eventually, the asymmetric clones are restored using LOCC, with a tiny amount of entanglement visible among the target nodes and the classic information sent from the source node. ".
Source link: https://doi.org/10.3390/app12126163
"Neuregulin-1 up-regulates in vitro, in vitro, neuregulin-1 rises, whereas Herceptin treatment down-modulates hMena's expression, meaning that it may be related to actin cytoskeleton signaling. " Whereas hMena overexpression consistently characterizes tumor cells of various lineages, the transformed phenotype of tumor cells of various lines of origins, but not so prevalently present in epithelial tumor cell lines. The percentage of phosphorylated hMena+11a isoform only in breast cancer cell lines; epidermal growth factor treatment promotes concomitant up-regulation of hMena and hMena+11a, resulting in an increase in breast cancer cell lines' proportions. As shown in hMena+11a cell lines, increased p42/44 mitogen-activated protein kinase activation and cell proliferation, as shown by the hMena+11a transfected breast cancer cell lines. The present findings show that actin cytoskeleton regulatory proteins and, in particular, hMena isoforms in coupling many signaling pathways involved in breast cancer coupling various signaling pathways.
Source link: https://doi.org/10.1158/0008-5472.can-06-1997
"Abstract Estrogen receptor-u03b1 and its ligand estradiol play key roles in breast cancer development and are important therapeutic targets for this disorder. Using chromatin immunoprecipitation on chip, ligand-bound ERu03b1 was recently discovered to act as a master transcriptional regulator by binding to several cis-acting sites genome-wide. We used an alternative approach in breast cancer cells and found 94 ERU03b1 target loci in breast cancer cells. These genes are highly ER-u03b1 responsive both in vitro and in vivo, according to mRNA profiling in estradiol-treated breast cancer cell lines and tissues. Wnt11, an estradiol-induced gene, was discovered to raise cell survival by significantly reducing apoptosis in breast cancer cells. "We also displayed new genomic binding sites of ERu03b1 that control a new subset of genes in response to estradiol in breast cancer," we explained together.
Source link: https://doi.org/10.1158/0008-5472.can-06-3696
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