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Background malnutrition and sarcopenia are prognostic indicators of overall health in patients, and they have a huge effect on liver cirrhosis prognosis. Patients with compensated cirrhosis are malnourished, while 20% of patients with compensated cirrhosis are malnourished. Aim This was the purpose of this research, which was to determine if prevalent malnutrition and sarcopenia among LC patients, at a tertiary hospital in Ludhiana, Punjab, and to investigate additional parameters that could be related to hunger using PG-SGA. Alcohol was one of the most common causes of liver cirrhosis. Child Pugh's score and GI symptoms were highly correlated with diet and digestion problems. If sarcopenia and malnutrition are detected early, diet modification and patients'u2019 prognosis can be enhanced. Rather than going for a CT-based sarcopenia evaluation, the study's findings suggest that PG-SGA and SARC-F could be used for assessment of hunger and sarcopenia in early stages of liver cirrhosis.
Source link: https://doi.org/10.1186/s41110-023-00189-9
Background and goal In China, hepatorenal syndrome is a significant complication in the decompensated stage of hepatitis B cirrhosis, which requires early clinical intervention, so early diagnosis of hepatorenal syndrome is critical. Patients with decompensated hepatitis B cirrhosis who met the inclusion and exclusion criteria were retrospectively accepted. Patients were randomly assigned to the training dataset and validation dataset at a 7:3 percent. Results This report included 255 patients with decompensated hepatitis B cirrhosis, including 184 in the training group and 70 in the validation group. According to the training group and the validation group, the area under the ROC curve of the nomogram for the diagnosis of hepatorenal syndrome was 0. 968 and 0. 980, respectively. Conclusions The three serum biomarkers, hemoglobin, total bilirubin, and creatinine can all be used as early predictors of hepatorenal syndrome in patients with decompensated hepatitis B cirrhosis.
Source link: https://doi.org/10.1186/s12876-022-02618-x
The presence and severity of PH are determined by a Hepatic vein pressure gradient, but this test is only available in designated centers. The aim of this paper is to critically evaluate and summarize the literature on SSM as a predictive instrument of liver decompensation and prognosis, stressing the strengths and the potential shortcomings of the studies that have been published so far. According to Expertu2019's analysis, the effectiveness of SSM in ruling out high risk of bleeding varices in cirrhotic patients has been established, leading to the Baveno VII consensus to include SSM in its final recommendations, although its use in patients with non-viral cirrhosis remains to be validated. Herein, we present the evidence that supports this belief, pointing to these areas that should be further investigated in order to elucidate and expand the use of SSM in the treatment of patients with liver cirrhosis.
Source link: https://doi.org/10.1007/s12328-022-01752-z
Hepatitis C virus can infect the liver and cause fibrosis as a result of chronic infection. Here we used multi-omics analysis of portal and peripheral blood, faeces, and liver tissue to help patients with HCV across a fibrosis severity gradient before and six months after sustained virologic response, namely, no detection of the virus. Portal glycan degradation was traced to gastrointestinal glycan breakdown, which in turn was associated with elevated portal inflammation in HCV. These findings contribute to our knowledge of the gut-u2013liver axis in HCV and non-HCV liver disease aetiologies, as well as future therapies. Microbiome, liver, and blood samples from patients with hepatitis C infection before and after removal of the virus showed metabolic dysregulation along the gut-u2013liver axis.
Source link: https://doi.org/10.1038/s41564-022-01273-y
Liver cirrhosis is a disease that affects a large population around the world. Liver cirrhosis is now divided into four stages. Using machine learning, this paper aims to determine the stage of liver cirrhosis of a patient. It is a controlled learning problem of multiclass classification. In this paper, a feature selection scheme based on random forest and mutual information was introduced, and its results were compared to the standard Random Forest method for feature selection in classification problems. Experimental results showed that the RF + MI strategy achieved marginal improvement in comparison to random Forest for feature selection.
Source link: https://doi.org/10.1007/978-981-19-3679-1_9
Global alcohol consumption per capita increased from 5. 5 litres in 2005 to 6. 4 litres in 2016 and is projected to rise to 7. 6 litres in 2030. Currently, Europe has the highest alcohol consumption figures; however, by 2030, countries/regions in the Western Pacific region is projected to exceed Europe's countries/regions. One-quarter of global cirrhosis deaths and one-fifth of liver cancer deaths in 2019 were estimated to be linked to alcohol use. liver-cancer deaths from 2010 to 2019 were the second-fastest-growing cause of liver-cancer deaths. Patients with alcohol-associated hepatocellular carcinoma tend to develop advanced tumors in some cases, which can be traced in part to late diagnosis and poor access to HCC screening in comparison to other aetiologies of liver disease. Global alcohol intake has increased in the last two decades in the last two decades and is expected to rise even more. According to the authors, the global estimated age-standardized death rate of alcohol-associated cirrhosis was 4. 5 percent in Africa and the Western Pacific, respectively, with the highest and lowest ASDR in Africa and the Western Pacific. The incidence of hepatocellular carcinoma in patients with alcohol-associated cirrhosis ranged from 0. 9 percent to 5. 6 percent. About one-fifth of global HCC-related deaths in 2019 was attributed to alcohol. The global estimated ASDR for alcohol-associated cirrhosis decreased between 2012 and 2017, but the ASDR for alcohol-associated liver cancer increased between 2012 and 2017. To minimize the burden of alcohol-associated cirrhosis and HCC, alcohol-related cirrhosis and HCC must be reduced.
Source link: https://doi.org/10.1038/s41575-022-00688-6
Purpose: Summary - so far, no attention has been paid to bariatric surgery in patients with extreme hunger and cirrhosis with portal hypertension. We systematically reviewed the available literature and findings on BS in patients with SO and cirrhosis with PH to fill this knowledge gap. In 27 patients, sleeve gastrectomy was the most common form of BS. Perioperative transfusions were seldom needed, with only one case report describing the use of 1 unit of packed red blood cells post-operatively. During the follow-up periods, both patients reported significant weight loss with rises in comorbidities. Overall, 27 out of 29 patients had T2DM resolution, and 13 out of 23 had arterial hypertension resolution, and 13 out of 23 had arterial hypertension resolution. Conclusion This systematic review highlighted the findings of BS in patients with cirrhosis and PH in SOs. These patients' doing this type of surgery seems to be safe and associated with good perioperative and long-term outcomes.
Source link: https://doi.org/10.1007/s11695-022-06362-9
Our aim is to investigate the serum zinc levels in Hepatitis B liver cirrhosis patients and to establish the connection between the serum zinc levels and the development of hepatocellular carcinoma. Patients with Hepatitis B liver cirrhosis were treated with nucleoside analogues therapy at China-Japan Union Hospital of Jilin University from January 2009 to December 2019. During an observation period of the median follow-up time, twenty-eight of 295 patients experienced HCC. According to Child-Pugh C. , the proportion of grade zinc deficiency was 64. 8 percent, but multivariate analysis showed that zinc, not significant for lowering the incidence of HCC. P 0. 001. Child-Pugh grade C was more than Child-Pugh grade B and A, p 0. 001. However, the link with hepatocellular carcinoma also needs to be investigated further.
Source link: https://doi.org/10.1007/s12011-022-03156-z
Liver cirrhosis is the fibrosis of liver caused by a long-term injury of the organ. For the classification purpose, twelve ML algorithms were used, with the highest accuracy of 68. 21% for the Histogram Gradient Boost Classifier. For further enhancement of the precision, hyper-parameter calibration was performed on all of the ML algorithms, which achieved the highest accuracy of 77. 97% for the Gradient Boost Classifier. The stacked model featured the GBC as the meta-learner, the Support Vector Machine, Xtreme Gradient Boost algorithm, Support Vector Machine, and the Light Gradient Boost Machine as the base-learners, with K-Nearest Neighbor as the base-learners, as the base-learners, as the base-learners, with the GBC as the meta-learner, Support Vector Machine, Support Vector Machine.
Source link: https://doi.org/10.1007/978-981-19-5403-0_31
Background: Although studies have shown that liver cirrhosis can influence cardiac hemodynamics by means of circulatory overload, patients with cardiac dysfunction, they do not present with a specific cardiac abnormal change, mainly with end-stage disease. Patients with cirrhosis of Child-Pugh A/B class and sixty-two healthy subjects were prospectively evaluated by standard conventional echocardiography and deformation imaging with rotational echocardiography. The clinical stage of liver cirrhosis was evaluated by a tool for end-stage liver disease scores and CTP classification. Means Mean age of patients with cirrhosis and controls was 56. 4 years and 52. 24 years, respectively. Although left ventricular dimensions and volumes were significantly higher in patients with cirrhosis, Simpsons' method did not reduce among controls, although control ejection percentages were also higher among controls. In patients with cirrhosis, the median value of torsion parameters did not differ compared to controls. Patients with Child-Pugh A and B stages of cirrhosis have preserved longitudinal strain, normal torsion, but with subtle diastolic dysfunction.
Source link: https://doi.org/10.1007/s12664-022-01277-w
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