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Cirrhosis - DOAJ

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Last Updated: 15 January 2023

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Correlation of Transient Elastography and Progression of Cirrhosis in Longterm Survivors of Biliary Atresia

In a long-term follow-up of pediatric patients with biliary atresia, this research sought to use transient elastography to determine the correlation between liver stiffness measurement and functional status of native liver. Methods: A transient elastography was performed on 20 cases of BA who had undergone hepatic portoenterostomy and had a promising initial result. On linear regression, LSM was significantly related to pediatric end-stage liver disease score at the r2 of 0. 8 percent and correlated with the aspartate transaminase to platelet ratio index at the r2 of 0. 70. The area under the receiver operating characteristic curve that represented LSM's success in predicting esophageal variances was 0. 97. Both 100% and 77% of respectively at the cut-off value of 10. 2 kPa, respectively, but with the sensitivity and specificity of LSM in predicting esophageal varices. In a long-term follow-up to BA, TE can be used as a non-invasive, point-of-care review of liver fibrosis.

Source link: https://doaj.org/article/c700184f161d4d97a806b233a4d3f040


Incidence of major depressive disorder over time in patients with liver cirrhosis: A nationwide population-based study in Korea.

According to the use of a claims database in Korea, the number of newly diagnosed patients with MDD divided by the sum of observation periods was determined. In the control period, the Incidence Ratio was defined as the IR in the particular interest period divided by the IR in the control period. Development of depression mildly grew before diagnosis of cirrhosis and then rapidly increased after diagnosis of cirrhosis. According to this, physicians must pay close attention to screening for depression within the first three months of liver cirrhosis diagnosis.

Source link: https://doi.org/10.1371/journal.pone.0278924


Association between probiotic therapy and the risk of hepatocellular carcinoma in patients with hepatitis B-related cirrhosis

This retrospective review was conducted to determine whether probiotics and hepatocellular carcinoma in patients with hepatitis B-related cirrhosis receiving antiviral therapy between January 2013 and December 2017. Following PSM, the incidence of HCC in the probiotic users was significantly lower than that in the nonusers. The use of probiotics may reduce the risk of HCC in patients receiving antiviral drugs for HBC, according to a multivariate stratified review.

Source link: https://doi.org/10.3389/fcimb.2022.1104399


Profiles of Clinical and Liver Function Test of Hepatitis B and C Patients with Liver Cirrhosis

Abstract: Liver cirrhosis is a degenerative liver disease epidemic affecting people with liver cirrhosis caused by hepatitis B and C, which is ranked 14th as a global issue and has a high incidence rate. Results: The majority of cirrhosis patients were males over 40 years old, and the majority of patients had liver cirrhosis caused by hepatitis B and C. The study was analyzed scientifically to determine the difference between patients with liver cirrhosis caused by hepatitis B and C. Subjects with hepatitis B and C had a median length of stay of 7. 00 days, with a mean of 7. 16 days. Conclusion: There was no significant difference between patients with liver cirrhosis caused by hepatitis B and C in liver cirrhosis caused by hepatitis B and C in liver cirrhosis caused by hepatitis B and C.

Source link: https://doi.org/10.20473/juxta.V14I12023.30-35


Antibiotic prophylaxis in cirrhosis patients with upper gastrointestinal bleeding: An updated systematic review and meta‐analysis

Objectives: According to emerging evidence, antibiotic prophylaxis may be skipped in early cirrhosis patients with elevated blood loss, chronic bleeding, and the need for salvage therapy may have influenced rebleeding, death, and ongoing bleeding. As the UGIB's leadership has progressed since the last review a decade ago, we performed a new meta-u2010analysis to determine the benefits of antibiotic prophylaxis in cirrhosis patients with UGIB. Although antibiotics reduced the chance of rebleeding and the amount of blood transfusion, they did not reduce the risk of death from chronic bleeding nor the need for salvage therapy. The length of stay in the intensive care unit can be reduced by antibiotic prophylaxis. Early cirrhosis with UGIB is characterized by the low risk of infection and death, so dedicated research are needed to determine the benefit of antibiotic prophylaxis in early cirrhosis with UGIB.

Source link: https://doi.org/10.1002/poh2.35


Liver cirrhosis in Japan: Future global trends in the era of progressive antiviral therapy

Abstract In Japan, viral hepatitis is the most common cause of chronic liver disease, including liver cirrhosis. Many elderly patients have been infected with hepatitis C virus for a long time have been in Japan, and antihepatitis steps have been in place since the 2000s. Although viral hepatitis remains a leading cause of liver cirrhosis in Japan, nonviral cirrhosis is now believed to be increasingly contributing to liver cirrhosis pathologies, as opposed to viral hepatitisu2010-related liver cirrhosis. Chronic liver disease trends in Japan can be predicted by the changing etiology of liver cirrhosis.

Source link: https://doi.org/10.1002/poh2.30


Simultaneous splenectomy improving the outcomes of patients with hepatocellular carcinoma, cirrhosis and portal hypertension treated with hepatectomy

Abstract Aims Patients with chronic hypertension and clinically high portal hypertension commonly have concomitant secondary hypersplenism, and splenismectomy is often recommended in the Asia-Pacific zone, according to the authors. CSPH is the most significant risk factor for postoperative liver dysfunction in patients with hepatocellular carcinoma and cirrhosis undergoing liver transplantation. However, the consequences of simultaneous Spx and hepatectomy in patients with HCC and CSPH are uncertain. Results According to 90-day SPLD-u2010related mortality, logistic regression analyses revealed that Spx was an independent risk of acute postoperative liver disease and 90u2010-related mortality. According to Cox regression results, Spx was also independently associated with a higher overall survival rate. The benefit of Spx was also consistent across the various study subgroups of major and minor hepatectomy. Conclusions Simultaneous Spx improved the outcomes of patients with HCC, cirrhosis, and CSPH treated with hepatectomy, including patients who underwent major and minor hepatectomies.

Source link: https://doi.org/10.1002/poh2.29


The natural history of patients with compensated cirrhosis and elevated hepatic venous pressure gradient

The Hepatic venous pressure gradient seems to be one of the most reliable predictors of medical outcomes. We identified and analyzed 20 patients with HVPG > 12 mmHg without evidence of clinical decompensation, among these patients. In addition, we compared this group to 40 randomly selected cirrhotic patients with HVPG > 12 mmHg with signs of clinical decompensation. Patients with elevated HVPG without evidence of clinical decompensation had a significantly lower outlook for end-u2010stage liver disease symptoms compared to decompensated patients. Over follow-up to 33 months, 8/20 compensated patients had a decompensating event, and no MELD nor HVPG distinguished patients who were still compensated from those that decompensated. Patients who remained compensated were significantly higher in patients who recovered than those who were not compensated than those who were participating in a decompensation event. Conclusions A small, unique group of cirrhotic patients with significantly elevated HVPG levels appears to be trouble free of complications regarding the long-term follow-up to u2010a.

Source link: https://doi.org/10.1002/poh2.27


MRI in liver cirrhosis

Patients with liver disease are now the gold standard for the diagnosis of hepatocellular cancer in patients with liver cirrhosis since its first appearance in the early 1980s. With the slew of procedures now available and the number of cirrhosis characteristics that can be assessed by single scans, MRI research and use of the technique make a logical target in the hunt for a technique for use in this group of patients who often have to attend multiple appointments and multiple tests, including invasive investigations.

Source link: https://doi.org/10.1002/poh2.6


Tolerance and acceptance of hepatic venous pressure gradient measurement in cirrhosis (CHESS1904): An international multicenter study

Aim: To determine the sensitivity and acceptance of hepatic venous pressure gradient measurements in patients with liver cirrhosis, see aim. Methods This prospective international multicenter study included 271 patients with cirrhosis who were scheduled to undergo HVPG testing between October 2019 and June 2020. HVPG measurements were highly accurate in all 271 patients, with 141 of them doing HVPG testing alone. Preoperative pain and intraoperative pain were significantly lower than preoperative, and intraoperative pain were also significantly lower than preoperative expectations, and intraoperative pain were also significantly lower than preoperative pain and intraoperative pain, and intraoperative pain was significantly less than preoperative anticipation pain and intraoperative pain, and intraoperative pain was also less than preoperative pain. According to 35. 1% and 4. 1% of HVPG tests as being of little or no assistance, respectively, 39. 5% had no understanding and 10% had no idea of the value of the HVPG test. 65% said that most patients would definitely, probably, or perhaps opt to have additional HVPG tests, and that 62. 7% thought the procedure was fair.

Source link: https://doi.org/10.1002/poh2.4

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions