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Cirrhosis - Astrophysics Data System

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Last Updated: 15 January 2023

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Clinical characteristics and predictors of esophagogastric variceal bleeding among patients with HCV-induced liver cirrhosis: An observational comparative study

Objectives: To investigate the clinical, risk factors, and predictors of esophagogastric variceal bleeding in patients with hepatitis C virus-induced liver cirrhosis, we need to find out. Methods This comparative observational study was conducted on 100 patients admitted to the Internal Medicine Department of Al-Azhar University Hospital, Damietta Egypt, suffering from post hepatitis cirrhosis and portal hypertension. Patients were divided into two groups: 50 of them had esophagogic varices with acute vaginal bleeding, while 50 percent were without bleeding, and 50 percent were classified as non-bleeding. The mean age of patients with bleeding was marginally higher than those without bleeding, p = 0. 049. Laboratory findings are more accurate in predicting vaginal bleeding and excluding non-variceal bleeding; however, medical signs should not be ignored, particularly H. pylori infection, ascites, and the Child-Pugh score.

Source link: https://ui.adsabs.harvard.edu/abs/2022PLoSO..1775373E/abstract


Nosocomial infections in female compared with male patients with decompensated liver cirrhosis

This research sought to investigate gender-specific variations in the occurrence and clinical course of nosocomial infections in patients with decompensated liver cirrhosis. A number of 556 consecutive hospitalized patients with decompensated liver cirrhosis and ascites were analyzed, ascites. While the prevalence of a nosocomial spontaneous bacterial peritonitis was similar among males and females, the prevalence of a nosocomial urinary tract infection was markedly higher in women. There seem to be no significant differences between male and female patients in the incidence and results of nosocomial infections.

Source link: https://ui.adsabs.harvard.edu/abs/2022NatSR..12.3285G/abstract


Diagnostic performance of two non-invasive biomarkers used individually and in sequential combination for cirrhosis associated with hepatitis C virus infection

When used alone or in a sequence combination to diagnose cirrhosis associated with hepatitis C virus infection, this cross-sectional report evaluated the performance of the Aspartate Aminotransferase-to-Platelet Ratio Index and the Fibrosis-4 Index. The final report included 906 people living with hepatitis C. The diagnostic results of individual biomarkers in cut-off scores of 1. 5 and 2. 0 for the APRI and at 3. 25 for the FIB-4 index were determined. Overall, the APRI and FIB-4 Index were both more effective in detecting cirrhosis associated with hepatitis C when they were used in sequence as a group.

Source link: https://ui.adsabs.harvard.edu/abs/2022NatSR..1220153S/abstract


The effect of induced hyperammonaemia on sleep and melanopsin-mediated pupillary light response in patients with liver cirrhosis: A single-blinded randomized crossover trial

Objectives & aims Sleep disturbances in patients with cirrhosis are attributed to hepatic encephalopathy and hyperammonaemia. In patients with cirrhosis, the aim of the study was to determine whether induced hyperammonaemia impacts pupillary light response and sleep quality. Sleep was rated by the Pittsburgh Sleep Quality Index and monitored for ten nights with wrist accelerometers and sleep diaries for twelve nights. Patients were randomly assigned either an oral amino acid challenge or an isocaloric glucose solution on two experimental days, separated by a week. Patients' sleep quality was poor, according to the patients. The time spent in bed sleeping after AAC was longer and with a reduced movement index compared to baseline, but not different from GS. When comparing the effects of AAC with GS, we found no difference in the pupillary light response or neuropsychiatric assessments. Patients with cirrhosis had poor sleep quality, according to the authors.

Source link: https://ui.adsabs.harvard.edu/abs/2022PLoSO..1775067K/abstract


Fibrosis-4 index efficiently predicts chronic hepatitis and liver cirrhosis development based on a large-scale data of general population in Japan

The incidence of high FIB-4 index and mean body mass index did not rise during the 30 years. A healthy liver was highly linked to BMI, but not with alcohol intake or the FIB-4 index. The risk of chronic hepatitis and liver cirrhosis was higher in patients without fatty liver than in those with it, and even higher in those with a high FIB-4 index than those without it.

Source link: https://ui.adsabs.harvard.edu/abs/2022NatSR..1220357Y/abstract


Incidence of major depressive disorder over time in patients with liver cirrhosis: A nationwide population-based study in Korea

The number of newly diagnosed patients with MDD divided by the number of observation periods was calculated by the Incidence Rate, which was determined by using the claims database in Korea. Ratio was characterized as the IR in the specific interest period divided by the IR in the control period. The IRR of developing depression mildly increased before diagnosis of cirrhosis and then soared sharply after diagnosis of cirrhosis. Clinicians must pay close attention to depression screening within the first three months of liver cirrhosis diagnosis.

Source link: https://ui.adsabs.harvard.edu/abs/2022PLoSO..1778924S/abstract


A simple covert hepatic encephalopathy screening model based on blood biochemical parameters in patients with cirrhosis

Although diagnosis is difficult, Aim Covert hepatic encephalopathy adversely affects clinical outcomes in patients with liver cirrhosis. Methods This retrospective analysis included 439 patients who were screened for CHE using a neuropsychiatric questionnaire between January 2011 and June 2019. Hypoalbuminemia and hyperammonemia were assigned as a single point each in a simple CHE score. Using logistic regression and Fine-Gray competing risk regression models, the relationship between sCHE scores and CHE or overt hepatic encephalopathy was investigated. The distribution of sCHE scores was 48% with 0 point, 33% with a point, and 19% with 2 points. Patients with a sCHE score of u22651 1. 14 percent had a higher incidence of CHE than those with a sCHE score of 0 or 0. According to a multivariate report, sCHE's score u22651 1 and CHE independently predicted OHE. Conclusions The sCHE score is a useful screening tool for identifying patients with CHE and predicting OHE prevalence.

Source link: https://ui.adsabs.harvard.edu/abs/2022PLoSO..1777829M/abstract


Prophylactic antibiotics on patients with cirrhosis and upper gastrointestinal bleeding: A meta-analysis

Objectives: To determine if prophylactic antibiotic therapies for cirrhosis patients with elevated gastrointestinal bleeding, and whether prophylactic antibiotics are equally effective at lowering the risk of adverse outcomes in A/B with poor Child-Pugh scores. The use of prophylactic antibiotics was used to assess prophylactic antibiotic risks in cirrhosis patients with UGIB, according to a 95% confidence interval and a 95% confidence interval. Among patients with UGIB, there was a reduced overall mortality, bacterial infections, rebleeding, and length of hospitalization [weighted mean difference : 3. 654, 95%CI: -6. 165 to -1. 543]. However, prophylactic antibiotics may not have a huge effect on A/B populations with low Child-Pugh scores. With cirrhosis patients with UGIB, quinolone, beta-lactams alone or in combination reduced adverse outcomes in cirrhosis patients with UGIB. In cirrhosis patients with UGIB, Quinolone, beta-lactams alone or in combination can be used in cirrhosis patients with UGIB.

Source link: https://ui.adsabs.harvard.edu/abs/2022PLoSO..1779496G/abstract


Health literacy in gastrointestinal diseases: a comparative analysis between patients with liver cirrhosis, inflammatory bowel disease and gastrointestinal cancer

Using the Health Literacy Questionnaire developed by Osborne et al. , health literacy was quantified. Patients with cancer had the highest health literacy across all nine subscales of the HLQ, while patients with cirrhosis had the lowest. "Having sufficient information to manage my health," says subscale "understand health care, more than patients with cancer and IBD" in detail, with patients with cirrhosis having significantly lower health literacy than patients with cancer or IBD" (also referred to as '"understand health care well enough to know what to do" says the narrhosis patient.

Source link: https://ui.adsabs.harvard.edu/abs/2022NatSR..1221072K/abstract

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions