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Chronic Pain - Wiley Online Library

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Last Updated: 26 April 2022

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Chronicity of posttraumatic stress disorder and comorbid pain as predictors of treatment response for trauma‐affected refugees

According to this report, the effects of posttraumatic stress disorder chronicity and baseline comorbid pain on patient response in trauma-affected refugees were investigated. Multiple regression was used to analyze results from a randomized controlled trial of 318 trauma-affected refugees with PTSD that was conducted at a private psychiatric clinic in Denmark. p =. 03, f2 =. 03, no predictor of depression; duration of functional impairment was found to be a good predictor of PTSD outcomes, p =. 02; it was not predictive of outcomes. P =. 02, f2 =. 02, f2 =. 02, and depression, p =. 01, f2 =. 01. These results show that trauma-affected refugees with long-lasting functional impairment and a high pain score are likely to show less improvement from treatments for PTSD and depression.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/jts.22839


Relationship between the morphology and composition of the lumbar paraspinal and psoas muscles and lumbar intervertebral motion in people with chronic low back pain

This research was designed to determine if there is a correlation between lumbar intervertebral movement and changes in lumbar morphology/composition in people with chronic low back pain. This cross-sectional research included a sample of 183 patients with CLBP. In participants with greater intervertebral mobility, participants with shorter total and functional CSAs of the lumbar erector spinae muscle were observed. Muscle asymmetry was found at different lumbar vertebral rates. At the L3-L4 level, the most translational intervertebral motion was present, while the majority of rotational translation was observed at the L4-level. The morphology of the spinal muscles at the vertebral level nearest to the L3-L4 level, as well as the increased intervertebral movement at this level were detected. The results may have a valid physiological explanation for the success of rehabilitationizing deficient inbound paraspinal muscles in a subset of people with CLBP.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/ca.23893


SIRT1: A promising therapeutic target for chronic pain

Abstract The chronic pain persists as unsolved problem. An increasing number of studies have shown that sirtuin 1 agonists can help with chronic pain. According to emerging research, SIRT1 activation may have positive effects on chronic pain relief by reducing inflammation, oxidative stress, and mitochondrial dysfunction. Therefore, SIRT1 agonists may be able to act as potential therapeutic agents for chronic pain.

Source link: https://onlinelibrary.wiley.com/doi/10.1111/cns.13838

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions