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Individuals with a history of traumatic brain injury have risen rates of chronic pain in chronic pain. Photosensitivity is also a common chronic condition following TBI and is widespread in other forms of chronic pain. Based on their Neurobehavioral Symptom Inventory results, the TBI group was divided into 120 symptomatic TBI participants and 113 Asymptomatic TBI participants. Participants in the s-TBI initiative scored significantly higher on self-reported chronic pain measures than those in a-TBI and no-TBI groups, including the Symptom Impact Questionnaire Revised and the Michigan Body Map. Despite differences in chronic pain reports, groups maintained similar pressure-pain thresholds. In addition, s-TBI participants were more alert to light, and VPT was linked to SIQR ratings across all participants. These results show that photosensitivity is linked to self-reported persistent pain and disability in patients with chronic TBI symptomatology.
Source link: https://doi.org/10.1089/neu.2022.0019
Chronic inflammatory pain is one of the most common subsets of chronic pain diagnoses, and it affects nearly half of patients in the United States and cost almost $600 billion each year. Evidence shows that melanocortin 4 receptors mediate pain-signaling and pain-like behaviors by doing activities at various nodes in the pain-neural axis, but the field still does not have a comprehensive understanding of the potential role of MC4Rs in chronic inflammatory pain in males and females. We can say with certainty that CFA causes long-term hyperesthesia in adult male and female Wistar rats, as well as long-term pain avoidance in male Wistar rats. Our results show that a model of chronic inflammation pain in adult male and female Wistar rats leads to long-lasting pain rises in pain-like behaviors, as well as female Wistar rats' antagonism, which is in effect.
Source link: https://doi.org/10.1016/j.neuropharm.2022.109032
Chronic pain remains one of the world's most common healthcare problems. Experts have recently launched evidence-based subtypes of chronic pain based on proposed underlying mechanisms to advance pain relief. In particular, correlational and behavioral studies show how anger is linked to the presence and severity of nociplastic pain. Functional neuroimaging studies also suggest nociplastic pain and healthy anger control; therefore, increasing anger control could normalize activity in these regions.
Source link: https://doi.org/10.1016/j.neubiorev.2022.104558
Despite increasing evidence of their poor effectiveness in chronic pain management and the potential for misappropriation, opioids are commonly prescribed for pain. We tested the possibility that acute and repeated dopamine agonist therapy would reduce mechanical hypersensitivity in male Long-Evans rats suffering chronic inflammatory pain. Both acute and repeated pramipexole therapy improved hyperalgesia-like behaviour in CFA-treated animals, but no analgesic effects were found in control animals, according to our results. We discovered that pramipexole treatment reduced AMPA receptor phosphorylation in the NAc and DS, but that pGluR1845 in the CC and CeA decreased. Following pramipexole therapy, pramipexole treatment in saline-treated animals increased psynapsin in the NAc, but not CFA-treated animals, indicating blunted presynaptic vesicle release in the NAc of CFA-treated animals. We used ex vivo electrophysiology to investigate the effects of pramipexole treatment in CFA- and saline-treated animals to investigate the functional implications of reduced presynaptic signaling in CFA animals' NAc. Pramipexole therapy reduced NAc intrinsic excitability in saline-treated animals, but there was no improvement in CFA-treated animals' intrinsic excitability. These results show that dopamine D2/3 receptor signaling in animals with a history of chronic pain in association with pramipexole therapy's anti-hyperalgesic effects.
Source link: https://doi.org/10.1016/j.neuropharm.2022.108976
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