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Chronic Kidney Disease - Wiley Online Library

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Last Updated: 15 July 2022

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Obesity and Chronic Kidney Disease A Current Review

Obesity and chronic kidney disease are also linked to obesity, which is not well described. Obesity can predispose to CKD specifically due to the histopathologic discovery of obesity-u2010-related glomerulopathy and indirectly through its well-known conditions such as atherosclerosis, hypertension, and type 2 diabetes. In addition, abdominal circumference measurements, as well as waist circumference, are generally associated with increased morbidity and mortality in patients undergoing maintenance haemodialysis. Obesity is a risk factor for the onset and progression of CKD and should be included as a potential target for a preventative public health initiative to reduce CKD rates in the general population. Patients with CKD and obesity patients with CKD and obesity must be evaluated using glucagonu20101 receptor agonists and sodium cotransporter 2 inhibitors due to their multi-faceted research into major findings.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/osp4.629


A nomogram to predict the in‐hospital mortality of patients with congestive heart failure and chronic kidney disease

Patients with chronic heart disease may also suffer from chronic kidney disease, and the two conditions could interact to raise the risk of death. This project was designed to investigate the risk factors contributing to inu2010hospital mortality in patients with CHF and CKD patients, as well as a statistical tool to calculate the risk of inu2010hospital mortality in patients with CHF and CKD, as well as creating a nomogram to predict the risk of in-u2010hospital mortality in patients with asthma. Methods and findings This retrospective analysis used data from the Marketplace for Medical Information in Intensive Care. In this research, patients with CHF and CKD in MIMIC u2010IV were included in this study. Comparing the nomogram model by the area under the receiver's operating characteristic curve and decision curve analysis, they were compared to the logistic Organ Dysfunction Score II and Logistic Organ Dysfunction Score II. The final cohort contained 4638 adult CHF and CKD patients; of them, 707 died and 3931 survived during hospitalization; of them, 3638 adult patients with CHF and CKD were included; of them, 707 died and 3931 survived during hospitalization. SAPS II and LODS' AUC reached 0. 747 and 0. 752, respectively, when the nomogram showed good accuracy for forecasting the in-u2010hospital mortality with an AUC of 0. 771. The nomogramogram model, rather than SAPS II, showed a greater net benefit than SAPS II when the threshold probability was reduced from 0. 05 to 0. 41. Results in this retrospective cohort study of patients with CHF and CKD found 13 independent variables associated with inu2010hospital mortality using LASSO logistic regression. For the first time, RDW, AG, and CRRT were all found to play a significant role in the u2010hospital mortality among patients with CHF and CKD.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/ehf2.14042


Erythropoietic effects of vadadustat in patients with anemia associated with chronic kidney disease

In patients treated with either vadadustat or darbepoetin alfa, hemoglobin concentrations were similar, but patients receiving vadadustat had erythrocytes with increased mean corpuscular volume and mean corpuscular hemoglobin, but not in patients receiving darbepoetin alfa, although the red cell distribution width was reduced. Patients randomized to vadadustat versus patients randomized to darbepoetin alfa were shown to have reduced transferrin saturation in patients with elevated serum transferrin concentrations as a result of increased serum transferrin capacity as well as stable serum iron indices. In patients receiving vadadustat compared to those receiving darbepoetin alfa, the decreases in transferrin saturation resulted in marked declines in serum hepcidin and ferritin. Overall, vadadustat had positive results on three aspects of erythropoetin production in patients with chronic kidney disease: increased endogenous erythropoietin production, increased iron synthesis in erythroid cells, and elevated reticulocytes in the circulation.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/ajh.26644


Expert consensus on personalized initiation of glucose‐lowering therapy in adults with newly diagnosed type 2 diabetes without clinical cardiovascular disease or chronic kidney disease

Large-scale clinical trials show some conclusions based on the characteristics of adult T2D patients with no medical risk or chronic kidney disease. The most important reason for starting antidiabetic drugs is the safety and effectiveness for preventing target organ injury, such as CVD and CKD. The decision of personalized glucose lowering therapy regarding target organ protection is based on the various effects of antidiabetic drugs, patients' and their key risks, as well as socioeconomic factors. Based on the risk factors for atherosclerotic CVD, heart disease, CKD, primary fatty liver, and hypoglycemia, a large number of recommendations have been developed for optimal T2D management, including the glucose control target and the various effects of hypoglycemic agents.

Source link: https://onlinelibrary.wiley.com/doi/10.1111/jebm.12474


Pregnancy in cystinosis patients with chronic kidney disease: A European case series

Cystinosis is a rare autosomal recessive disease that contributes to end-stage renal disease in the second or third decade of life. Prognosis has dramatically improved during the period of specific therapy with cysteamine, and pregnancy is becoming an increasing concern. Patients with cystinosis were found among pregnant women with pregnancy through an anonymized poll. We collected statistics for 19 pregnancies in 12 women. Eleven patients were transplanted, one was on hemodialysis, and 1 had persistent kidney disease stage 4 or 4 in the chronic kidney disease epidemic. After being rejected early miscarriage or termination, the pregnancy success rate was 86. 7%. In healthy pregnancies, the average gestational age at birth was 34 weeks. One woman after pregnancy developed endoscopic renal disease after pregnancy, but she had already had advanced CKD before pregnancy. The majority of pregnancies were positive, but severe antenatal and postnatal complications could have arisen, in particular preeclampsia that was seen in nearly half of patients and fetal loss in one-third of them.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/jimd.12529


Erythropoiesis‐stimulating agents and incident malignancy in chronic kidney and end‐stage renal disease: A population‐based study

That is lacking data on incident malignancy risk in erythropoiesis-u2010stimulating agent users with persistent kidney disease. We wanted to compare the incidence of breast cancer risk among ESA and non-u2010ESA patients with CKD or end-stage renal disease. All adults with CKD or ESRD were enrolled in this retrospective cohort study, whether they were born or not. The amount of ESA required was determined by a standard daily dose of ESA. In the secondary studies, incident malignancy risk in different tertiles of cumulative ESA doses and the risk of various types of cancers were found. With ESA treatment than without ESA care, the risk of incident malignancy was 1. 84 times higher than without ESA intervention. With ESA treatment versus without ESA intervention, the risk of genitourinary malignancy was 12. 55 times higher than without ESA care. Patients with CKD or ESRD are at a greater risk of malignancy, especially genitourinary cancers.

Source link: https://onlinelibrary.wiley.com/doi/10.1111/cts.13353

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions