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Individuals with chronic granulomatous disease may have recurring bacterial and fungal infections. People with this disorder may also have areas of inflammation in various tissues that may result in tissue damage. Chronic granulomatous disease is a common disease that does not appear in childhood, although some people do not experience symptoms until later in life. At least one severe bacterial or fungal infection is present in every 3 to 4 years among people with chronic granulomatous disease in the majority. Individuals with chronic granulomatous disease may experience mulch pneumonitis, which causes fever and shortness of breath after exposure to decaying organic material such as mulch, hay, or dead leaves. People with chronic granulomatous disease and the numerous fungi involved in their decomposition can develop fungal infections in their lungs. The skin, liver, and lymph nodes are all typical points of infection in people with chronic granulomatous disease. In people with chronic granulomatous disease, inflammation can occur in many areas of the body. Inflammation in the stomach can block food from passing through to the intestines, resulting in an inability to digest food. Inflammation of the lymph nodes and bone marrow, which both produce immune cells, may lead to further impairment of the immune system. Rarely, people with chronic granulomatous disease have autoimmune disorders that occur when the immune system malfunctions and attacks the body's own tissues and organs.
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