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Chest Pain - ClinicalTrials.gov

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Last Updated: 19 November 2022

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Non Invasive Left Ventricle Contractility dp/dt Could be Used as a Prognostic Marker in Patients Admitted to the Emergency Department for Chest Pain

A significant public health issue remains ischemic heart disease. Despite all the advancements in the telelogist approach to ischemic heart disease, the danger of major cardiovascular events is not negligible. Several scores have been suggested for chest pain stratification risk, but the most widely used are the TIMI and GRACE scores. Because ischemia reduces myocardial contractility, the investigator cautioned that a lower value of dp/dt may be related to more significant cardiovascular events.

Source link: https://clinicaltrials.gov/ct2/show/NCT05416112


Influence of Intensive Lipid-lowering Witgh Statin and Ezetimibe Prescription on Computed Tomography Derived Fractional Flow Reserve in Patients With Stable Chest Pain

Patients with stable chest pain, moderate CAD, statin naive, and at least one translesional FFRct score 0. 81 are randomly assigned to either "atorvastatin 40 mg daily'" or "ezetimibe 10 mg daily" therapy. Changes in FFRct values from 0 to 9 months of follow-up studies, and changes in low density plaques volumes and number of lesions with positive change over time relative to changes in LDL cholesterol are all changes in FFRct values from 0 to 9, as shown by changes in LDL cholesterol.

Source link: https://clinicaltrials.gov/ct2/show/NCT05368545


The Value of Fractional Flow Reserve Derived From Coronary CT Angiography as Compared to CCTA or CCTA and Stress MPI in the Triage of Low to Intermediate Emergent Chest Pain Patients With Toshiba CT-FFR

History: Coronary Computed Tomography Angiogram is a non-invasive imaging technique that has a high sensitivity and negative predictive value for coronary artery disease detection. Recent advancements in computational fluid dynamic techniques applied to standard CCTA are now available as useful tools for virtual measurement of FFR from CCTA imaging. The primary aim of this review was to determine the incremental benefit CT-FFR in triaging chest pain patients in ED settings that are reported to have obstructive CAD on CCTA. Advances in computational fluid dynamics simulation techniques used to standard CCTA are now widely used as a useful tool for virtual measurement of FFR from CCTA imaging. Preclinical Data: Although few papers regarding the use of CT-FFR specifically address diagnostic work-up for obstructive disease, it is likely that the cost of diagnostic work-up will increase as a result of advancements in diagnostic testing will also change. From 1/1/2009 to 3/31/2015, the investigative team of Stony Brook University Hospital ED and non-emergency outpatient services, Suffolk County's sole tertiary care hospital in Suffolk County, New York, operated a CCTA Chest Pain triage service for low to intermediate risk patients from 1/1/2009 to 3/31/2015. Investigators at Stony Brook Medicine also maintained a registry to track patient outcomes for all patients receiving CCTA at Stony Brook Medicine. With a false negative rate less than 1% [5], the big registry study established the benefits of CCTA as an imaging modality for assessing ED chest pain in a cost-effective manner. Study Objectives: The aim of this report is to determine the incremental benefit of Fractional Flow Reserve derived from CCTA relative to invasive FFR as the gold standard for patients with obstructive disease. According to invasive FFR >=0. 8 and vessel diameter of >=2mm, this will be a prospective clinical trial to determine the incremental benefit of virtual FFR measured from CCTA, compared to invasive FFR and CCTA alone for the detection of flow-limiting coronary stenosis. Patients who present to the North Shore University Emergency Department for CCTA due to chest pain or angina for more than two years and meeting the study inclusion criteria are eligible for the research. Following CCTA scan acquisition of Toshiba America Medical Systems, Inc. 's eligible patients, all eligible patients will be evaluated for 320-slice multi detector CCTA and CT-FFR measurements. Patients with borderline or high CCTA stenosis readings will be subjected to ICA with invasive FFR testing as per approved guidelines and a common practice setting. Patients with 30% to 49% obstructive stenosis by CCTA standards and with positive CT-FFR will also undergo invasive FFR and follow the protocol for those with > 50% obstruction. Patients with 0 to 49% obstructive disease and negative CT-FFR will be sent to the best follow-up care only.

Source link: https://clinicaltrials.gov/ct2/show/NCT03329469

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions