Advanced searches left 3/3

Chagas Disease - Crossref

Summarized by Plex Scholar
Last Updated: 19 July 2022

* If you want to update the article please login/register

Digestive Disorders in Chagas Disease: Megaesophagus and Chagasic Megacolon

According to the WHO, Chagas disease, also known as American trypanosomiasis and spread by hematophagous vectors, is a parasitic disease that causes significant years of life, and it is ranked fourth as a cause of death of potential years of life due to disorders that can occur in multiple organ systems.

Source link: https://doi.org/10.5772/intechopen.102871


Translational Research on Chagas Disease: Focusing on Drug Combination and Repositioning

The comprehensive literature on protozoal parasitic diseases is reviewed, as well as repurposing disulfiram intended for use with the Chagas disease drug of choice benznidazole is discussed. Both disulfiram and its first derivative, sodium diethyldithiocarbamate, are able not only to inhibit p-glycoprotein, potentially reverting resistance phenotypes, but also reduced the toxicity of several other medications, heavy metals, etc. This innovation, which is still in clinical study, may lead to a new therapeutic for T. cruzi infections that improve the effectiveness of Chagas disease treatment.

Source link: https://doi.org/10.5772/intechopen.104231


The Saga of Selenium Treatment Investigation in Chagas Disease Cardiopathy: Translational Research in a Neglected Tropical Disease in Brazil

This chapter details the transition from basic research to the formulation of a concrete public health recommendation for patients with Chagas disease. We conducted a translational research project in 1998 to see whether chronic Chagas disease cardiopathy symptoms could be attributed to low blood selenium levels, and that oral Se supplementation could help to maintain the symptomatic cardiac disease stage and minimize disease severity.

Source link: https://doi.org/10.5772/intechopen.103772


New Therapeutics for Chagas Disease: Charting a Course to Drug Approval

This chapter explores the strategic and organizational challenges faced in the development of a new antitrypanosomal drug for Chagas disease. The findings herein should be a resource to help researchers and other stakeholders optimize their clinical research efforts and expedite delivery of new medications to patients with Chagas disease.

Source link: https://doi.org/10.5772/intechopen.102891


Three and two-dimensional cardiac mechanics by speckle tracking are predictors of outcomes in chagas heart disease

Abstract: Chagas disease is a neglected infectious disease associated with early mortality and significant disability in eastern Canada. In the analysis of CD, three-dimensional speckle tracking may have a role. We want to identify new echocardiographic features in patients with CD, as well as test the likelihood that 3D STE may predict outcomes. U2264 16%, right ventricle GLS % u2264 u2212 13%, 2D LV global longitudinal strain u2212 13%, 3D LV global circumferential strain u2212 13% u2212 13% u2212 13%, 3D LV global circumferential strain u2264 10. 6% u2212 17%, U2264 11. 9% -u2212 13% u2212161664 u2264 u221212121212131212121216161212121211u221216121212121212121211 u221212 u221211236u22121212, 266 u2212121211u2212121212121212121212161212121212161212121212121216121212121212 Despite the benign evolution of the pLVEF group, patients with CD and mrLVEF were morphologically similar to the rLVEF patients. RV GLS, 2D LV GLS, 3D LV GCS, 3D LV GLS, 3D LV GLS, 3D LV GLS, 3D LV GCS, 3D LV GLS, 3D LV GLS, 3D LV GLS, 3D LV GCS, 3D LV GLS, 3D LV GLS, 3D LV GLS, 3D LV GLS, 3D LV GLS, LV GLS, 2D LV GLS, 2D LV GLS, 3D LV GLS, 3D LV GLS, 3D LV GLS, 3D LV GLS, 3D LV GLS, 3D LV GLS, 3D LV GLS, 3D LV GLS, 3D LV GLS, 3D LV GLS, 3D LV GLS, 3D LV GLS, 3D LV GLS, 3D LV GLS, 3D LV GLS, 3D LV GLS, 3D LV GLS, 3D.

Source link: https://doi.org/10.1038/s41598-022-16379-w


Chagas disease in children from the Gran Chaco region: A bibliographic appraisal

The Pan American Health Organisation reported the cessation of Chagas Disease vector transmission in Paraguay and some parts of Argentina's Gran Chaco region. Due to its socioeconomic and ecological characteristics, the Gran Chaco region remains a hotspot for Chagas Disease, impacting disproportionally rural populations and some marginalized populations.

Source link: https://doi.org/10.1177/00494755221103002


Diagnosis and Prevalence of Chagas Disease in an Indigenous Population of Colombia

Chagas disease is one of the most common neglected tropical diseases worldwide. CD is endemic in at least 21 countries in the Americas, but only less than 1% of patients have access to medical care. Diagnostic procedures and regional prevalence of the Chagas disease were also investigated in this report. With a Chagas-antibody-specific rapid test, two separate Chagas-antibody-specific ELISAs, and a Chagas-specific real-time polymerase chain reaction, nine people of the indigenous tribe Wiwa were tested in nine villages of the indigenous tribe Wiwa. 1134 people were tested in nine villages of the indigenous tribe Wiwa, 1134 people were tested, including two separate Chagas-antibody-specific ELISAs and a Chagas-monia The overall prevalence of CD in the villages was 35. 4%, with a range from 24. 9% to 52. 8% for the various groups. In conclusion, the surveyed indigenous population in Colombia was found to be highly affected by CD. Replacements of ELISAs by RT will save money, increase affordability, and can reliably help identify positive patients, particularly if integrated with the existing real-time PCR system.

Source link: https://doi.org/10.3390/microorganisms10071427


Cardiac autonomic function in Chagas disease: a narrative review

Chagas disease is a common health issue in Latin America, including Brazil, and it is described as an acute and chronic disease. CD can affect various organs and tissues, including the heart, which can lead to sudden death. This research sought to review the evidence on cardiac autonomic function in adult individuals who were tested by Heart Rate Variability in CD. Even in symptomatic patients, HRV's quantitative CD progression monitoring is an inexpensive way to detect changes in the cardiac autonomic nervous system. In CDs, physical activity can improve autonomic function.

Source link: https://doi.org/10.22278/2318-2660.2021.v45.n2.a3339


Mining SNPs in extracellular vesicular transcriptome of Trypanosoma cruzi : a step closer to early diagnosis of neglected Chagas disease

The Extracellular vesicles and their enclosed RNAs are among the best and most popular intercellular communicators; Extracellular RNAs have been recognized as putative biomarkers and therapeutic targets for various diseases. In recent studies, highly bioactive EVs have captured parasitologists' attention for being able to coordinate between various cells and having likeliness of representing both source and target environments. This paper was published in the following article by bioinformatics-based analysis and predictive data mining of transcriptomic data of EVs derived from various life stages of Trypanosoma cruzi; a cause agent of neglected Chagas disease. Some of the u2018candidate SNPs inu2019 were discovered to be stage-specific, which increases the likelihood of finding stage-specific biomarkers. These findings may lead to a greater understanding of Chagas disease, as well as improved knowledge, which may lead to further development of the biomarkers for diagnosis, treatment, and drug manufacture for Chagas disease.

Source link: https://doi.org/10.7717/peerj.2693

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions