Advanced searches left 3/3

Chagas Disease - ClinicalTrials.gov

Summarized by Plex Scholar
Last Updated: 10 December 2021

* If you want to update the article please login/register

Effect of Statins (Atorvastatin) on Inflammation and Cardiac Function in Patients With Chronic Chagas Disease: Pathophysiological Studies in a Multicenter Proof-of-concept

Chagas disease afflicts 7 million people in 21 native nations in Latin America and is increasing in non-endemic countries due to movement. Brain natriuretic peptide and cardiac troponin T have been suggested as beneficial biomarkers to forecast progression in the direction of left ventricular dysfunction. Chronic Chagas Cardiomyopathy is triggered by a parasite-dependent, immune-mediated myocardial damage, which is the most essential factor of the disease where the T helper 1/T helper 2/ T governing response is an important feature, where the balance in between too much pro-inflammatory and anti-inflammatory cytokines is essential for heart damages development. Also, microvascular problems and ischemia second to platelet activation and endothelial disorder, as shown by boosts in cell adhesion molecules Intercellular Adhesion Molecule type 1, Vascular Cell Adhesion Molecule, and E-selectin, including their soluble forms. Therapy of CCC and enhancement methods: In Chile, the etiologic therapy of CD in Chile is done with 5-10 mg/kg/day nifurtimox or 5 mg/kg/day benznidazole for 60 days. Therefore, a combination of trypanocidal drugs and those generating resolution of the inflammatory process obtained from bloodsucker persistence might be an audio restorative approach to avoid chronic repercussions of CD. There is a basic contract that adults with chronic indeterminate CD are the population with one of the most immediate requirements for the growth of new treatments due to the fact that of the highest disease problem to these patients. 20-80 mg/day atorvastatin is utilized to decrease the supposed LDL cholesterol involved in the pathogenesis of atherosclerotic cardio disease.

Source link: https://clinicaltrials.gov/ct2/show/NCT04984616

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions