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Cervical Dysplasia - DOAJ

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Last Updated: 07 September 2022

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Development of a Nomogram Predicting the Risk of Persistence/Recurrence of Cervical Dysplasia

The history: Cervical dysplasia persistance/recurrence has a major effect on women's health and quality of life. We investigated whether a prognostic nomogram could improve risk estimation after primary conization. Methods: This is a retrospective multi-institutional review based on charts of consecutive patients undergoing conization from 1 January 2010 to 31 December 2014. Results: A total of 2966 patients undergoing primary congesis were analyzed by a survey. 6% of patients at 5-years of follow-up had a persistent/recurrent cervical dysplasia. After conization, the risk of developing cervical dysplasia persistence/recurrence increased dramatically and independently of the risk of developing cervical dysplasia persistence/recurrence, Diagnosis of CIN3, presence of HR-HPV types, positive endocervical margins, HPV persistence, and the omission of HPV vaccination after conization increased significantly and independently of the likelihood of developing cervical dysplasia persistance/recurrence. Conclusions: The present nomogram is a useful tool for advising women about their chances of persistence/recurrence after primary conization. Since conization has been linked to a reduced risk of CIN2+, it has been recommended that HPV vaccination has been associated with reduced risk of CIN2+.

Source link: https://doi.org/10.3390/vaccines10040579


Efficacy of HPV Vaccination in Women Receiving LEEP for Cervical Dysplasia: A Single Institution’s Experience

After loop electrosurgical excision surgery in reducing recurrent cervical dysplasia, the aim of this research was to determine the role of a human papilloma virus vaccine. LEEP was distributed to a group of 503 people with cervical dysplasia between January 2012 and October 2018. Within four weeks of LEEP, one hundred eighty-two women were vaccinated with an HPV vaccine, while 103 were not vaccinated, but not vaccinated. With an odds ratio of 0. 2, the choice as a result of the review only revealed recurrence as severe cervical lesions. Since LEEP, the administration of an HPV vaccine after LEEP seems to reduce the likelihood of recurrence, thus suggesting that HPV vaccination may play a role as an adjuvant therapy after LEEP.

Source link: https://doi.org/10.3390/vaccines8010045


Adjuvant HPV Vaccination to Prevent Recurrent Cervical Dysplasia after Surgical Treatment: A Meta-Analysis

This meta-analysis sought to analyze evidence confirming the effectiveness of adjuvant human papillomavirus vaccination in lowering the risk of recurrent cervical intraepithelial neoplasia 2 or more after surgical therapy. Since vaccination was markedly lower in the vaccinated group relative to the unvaccinated group, the recurrence of CIN 2+ was significantly reduced. CIN 1+ recurrence of CIN 1+ after treatment was considerably lower in the vaccinated compared to the unvaccinated group. Conclusions: HPV vaccination, in the adjuvant setting, has been shown to a reduced risk of recurrent CIN 1+ and CIN 2+ after surgical care.

Source link: https://doi.org/10.3390/vaccines9050410


Prognostic impact of human papillomavirus infection on cervical dysplasia, cancer, and patient survival in Saudi Arabia: A 10-year retrospective analysis

BACKGROUND: In Saudi Arabia, information on human papillomavirus prevalence and survival rates among HPV-infected women is limited. OBJECTIVE: Examine the prevalence of HPV genotypes in cervical biopsy samples and its effect on survival over a 10-year time span. RESULTS: HPV was found in 96 patients: 37. 3% had cervical cancer; 14. 2% cervical intraepithelial neoplasia III, 5. 1% CIN II; and 17. 0% CIN I. A significant relationship was found between HPV presence and cervical cancer. P16INK4A was a significant predictor of resurrection: women with p16INK4a overexpression had lower survival rates: women with a p16INK4a overexpression had lower survival rates. HPV-positive women had higher survival rates than HPV-negative women, according to multivariate studies with HPV status and cervical cancer diagnosis. These results show that starting cervical and HPV screening services can reduce cervical cancer incidences and increase survival rates of women in Saudi Arabia's.

Source link: https://doi.org/10.5144/0256-4947.2021.350

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions