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Cervical Cancer - Springer Nature

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Last Updated: 19 June 2022

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Paeonol triggers apoptosis in HeLa cervical cancer cells: the role of mitochondria-related caspase pathway

"Paeonol is a biologically active component isolated from Cortex Moutan's root bark that causes pharmacological effects on cervical cancer. " We are going to assess paeonol's anti-cervical cancer capacity and investigate the mechanism responsible for its anti-cervical cancer effect in this report. In addition, paeonol therapy led to a mitochondrial dysfunction in HeLa cells, including the induction of mitochondrial membrane potential, reactive oxygen species production, and the emergence of cytochrome c. Consequently, paeonol has a lot of promise as a promising therapeutic agent to fight human cervical cancer. ".

Source link: https://doi.org/10.1007/s00213-021-05811-0


Two cases showing the effects of bevacizumab on recurrent cervical cancer with pleural effusion

"Becab is a drug that has been used to treat patients with chronic cervical cancer and pleural effusion. " We report two cases of recurrent cervical cancer with dramatically reduced pleural effusion and a long survival rate following combination chemotherapy with bevacizumab. Case 1: A patient was diagnosed with stage IIB cervical cancerosa and treated with concurrent chemoradiotherapy, total hysterectomy, and paclitaxel/carboplatin therapy as the primary therapy. A symptomatic pleural effusion emerged after the first recurrence had been treated with irinotecan u2013cisplatin therapy and radiotherapy. Paclitaxel-cisplatin-bevacizumab was used during 13 cycles of chemotherapy to quickly resolve pleural effusion, respiratory distress, and back pains during brief intervals of chemotherapy. Case 2: After CCRT, a patient was diagnosed with stage IIIB cervical squamous cell carcinoma and pulmonary recurrence. Despite being in the late phase, Chemotherapy with bevacizumab is effective for both symptom relief and change in prognosis in patients with recurrent cervical cancer.

Source link: https://doi.org/10.1007/s13691-022-00538-x


Evaluating the role of perceived injustice in mental health outcomes in cervical cancer care

"The purpose of this research was to investigate the effects of perceived injustice on psychological wellbeing among a group of cancer patients and survivors of the National Cervical Cancer Screening Program smear tests who obtained false-negative smear results. " Results of torture in this sample were high, with 76% scoring in the clinical range for fear, 51% in the clinical range for depression, and 88% in the clinical range for perceived injustice. Conclusions Cancer patients who have a high degree of perceived injustice are at a greater risk of experiencing mental instability. Dependence on caregiver satisfaction may vary as a result of caregiver satisfaction. Addressing issues of apparent injustice in cancer patients' psychosocial and rehabilitative care can help identify those patients at risk of significant psychological distress and increase intervention success. ".

Source link: https://doi.org/10.1007/s00520-022-07060-z


RNA modification “writer”-mediated RNA modification patterns and tumor microenvironment characteristics of cervical cancer

"This research looked at cervical cancer RNA change patterns in order to determine the overall effect of RNA modification on tumor microenvironment characteristics and immune/targeted therapy. " Methods 26 RNA modification "writers" were clustered, and the RNA modification and TME characteristics of cervical cancer patients in TCGA were systematically reviewed, with RNA modification results and TME characteristics of cervical cancer patients in TCGA. An RNA modification '"writer" score system was developed to measure RNA modification of a single sample of a single sample based on differentially expressed genes among various RNA modification styles. Poor prognosis, low immune infiltration, and low tumor mutation burden were all typical among the high WM score, while low WM scores were attributed to relatively long total longevity, more immune components in TME, and elevated TMB. Conclusions: This research established and described RNA modification patterns, established potential correlations between RNA modification strategies and immune infiltration characteristics and cervical cancer immunotherapy, and established a new evaluation method for cervical cancer patients.

Source link: https://doi.org/10.1007/s12094-022-02787-x


What MRI-based tumor size measurement is best for predicting long-term survival in uterine cervical cancer?

"Background Tumor size determination by MRI is vital for diagnosising uterine cervical cancer. However, the correct use of MRI-derived tumor measurements for prognostication is also uncertain. Methods and methods This retrospective cohort study included 416 women diagnosed with cervical cancer in 2002-2013 and those who underwent pretreatment pelvic ultrasound. The MRIs were independently read by three radiologists, determining maximum tumor diameters in three orthogonal planes and maximum diameter, regardless of plane size. Results All MRI tumor size variables yielded high areas under the tdROC curves for predicting survival at 5 years after diagnosis and predicted outcome. After 5 years, the most effective cutoff for maximum tumor diameter yielded a sensitivity of 83% for predicting disease-specific death. The inter-reader agreement for MRI-based primary tumor size measurements was outstanding, with ICCs of 0. 83u20130. 85. Conclusion "MAX_imaging was the only reliable predictor of survival" among all MRI-derived tumor size measurements, according to Professor Stanley.

Source link: https://doi.org/10.1186/s13244-022-01239-y


Comprehensive analysis of novel prognosis-related proteomic signature effectively improve risk stratification and precision treatment for patients with cervical cancer

"Objective Cervical cancer is one of the most common malignant female cancer diseases, and its incidence and mortality are not promising. Protein panels can be a useful diagnostic indicator of several forms of cancer. The aim of our investigation was to investigate a proteomic panel in order to predict the survival of patients with common CC. Methods and findings The protein expression and clinicopathological information of CC were downloaded from The Cancer Proteome Atlas and The Cancer Genome Atlas database, respectively. The results of functional enrichment analysis were mainly related to apoptosis, according to Univariate Cox regression analysis, and we found that the prognosis-related proteins were mainly related to apoptosis. In addition, we investigated for the co-expressed proteins of three-protein panels as potential prognostic proteins. Conclusions "According to the clinicopathologic signs," a proteomic signature influenced CC patients' OS of CC patients, and the predictive ability was higher than the clinicopathological characteristics.

Source link: https://doi.org/10.1007/s00404-022-06642-w


Women’s sexual autonomy as a determinant of cervical cancer screening uptake in Addis Ababa, Ethiopia: a case–control study

"Cervical cancer is the fourth most common cancer in women worldwide and the leading cause of cancer deaths in developing countries. " Therefore, this report sought to investigate women's sexual status as a determinant of lifetime CC screening among women in Addis Ababa, Ethiopia. In which controls were women who had received screening services for the last five years, women returning for other services were randomly selected from those who had not registered or aware of the screening program, but not many people were aware of the service or aware of it. To determine the women's sexual identity as a determinant of lifetime CC screening, bivariate and multivariable logistic regression studies were conducted. We found that women'u2019s sexual autonomy was largely responsible for the rise in CC screening uptake. Empowering women can remove barriers to CC screening in the community," she says.

Source link: https://doi.org/10.1186/s12905-022-01829-4


Knowledge, and practice of cervical cancer prevention and associated factors among commercial sex workers in Shashemene Town, West Arsi, Oromia Region, Ethiopia

"There is a limited study on cervical cancer incidence among Sex Workers in Ethiopia, but a study done in Central America reveals that HPV infection in sex workers is 2. 5 times higher than the general population. " However, there are no studies on cervical cancer prevention among Ethiopian sexual sex workers. Methods A systematic random sampling system and an interviewer were used to investigate the prevalence and practice of cervical cancer prevention and its associated factors among 405 women of commercial sex workers with a systematic random sampling system and an interviewer. About half of respondents have information about cervical cancer screening and its prevention, and their prevention, and 20. 3% of respondents were engaged in cervical cancer screening.

Source link: https://doi.org/10.1186/s12905-022-01819-6


A comparison of behavioural models explaining cervical cancer screening uptake

"While few studies have compared these models in terms of their ability to predict health behavior, this report examines three health behaviour theories in order to identify and compare CCS behavior and intention. Methods An investigation was conducted among 607 sexually active women in Karnataka, South India's southern state. Behaviour, Theory of Planned Behaviour, and the Theory of Care-Seeking Behaviour were all found in the Health Belief Model, socio-demographic factors, health literacy, information on CCS, and socio-cognitive attributes associated to CCS. Logistic regression experiments investigated to what extent each of the theoretical models explained cervical cancer screening intention and regular screening behavior, comparing the differences reported by each of the models. Conclusions "Wellbeing behavioural tools such as the TPB and HBM will help to determine the key socio-cognitive factors describing women's desire to enroll in CCS. ".

Source link: https://doi.org/10.1186/s12905-022-01801-2


Indocyanine green-guided sentinel lymph node mapping during laparoscopic surgery with vaginal cuff closure but no uterine manipulator for cervical cancer

"Background Lymph node metastasis is a significant prognostic factor in cervical cancer. " An accurate intraoperative analysis of the presence of lymph node metastasis in patients undergoing cervical cancer surgery is critical considering the potential risks of lymphadenectomy and desire for avoiding systemic lymphadenectomy. During laparoscopic surgery for cervical cancer, we investigated the potential and value of indocyanine green use for sentinel lymph node mapping. Methods This single-center cohort study included 77 patients who were undergoing a new laparoscopic radical surgery procedure with pelvic lymphadenectomy for early-stage cervical cancer in 77 patients. Tumors were significantly lower for tumors u2265 2 cm in diameter than for tumors 2 cm in diameter, but not for tumors 2 cm in diameter. Using ICG-based mapping for intraoperative identification of SLNs in patients undergoing this new laparoscopic surgery strategy for early-stage cervical cancer patients was especially helpful for tumors 2 cm in diameter. ".

Source link: https://doi.org/10.1007/s10147-022-02197-7

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions