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During follow-up, patients with locally advanced cervical cancer with no para-aortic lymph node metastases at diagnosis who receive concurrent chemoradiotherapy are at 41% risk of developing PAO-LNM. " The aim of this research was to synthess and meta-analyse literature on the effect of PAO-RT on cervical cancer patients. The review included research studies that reported on DFS in patients with cervical cancer who underwent chemotherapy and pelvic radiotherapy with or without PAO-RT. From each included review, reliable study findings, and outcome data including the hazard ratio adjusted for potential confounders were extracted. After PAO-RT versus no PAO-RT was calculated using a random-effects scheme, an overall pooled adjusted hazard ratio for DFS was calculated. Conclusions: This meta-analysis shows that elective para-aortic radiotherapy has a modest yet highly beneficial effect on DFS in patients with locally advanced cervical cancer who require concurrent chemotherapy.
Source link: https://doi.org/10.1016/j.ctro.2022.05.006
"PURPOSEPatients with advanced and metastatic cervical cancer have a poor prognosis, with a 1-year survival rate of 10%-15%. " paraphrasedoutput:METHODS is a website that distributes the results of a hypothetical cohort of 1,000 patients with advanced and metastatic cervical cancer in India. This research was designed to determine the costs and health outcomes of patients with advanced and metastatic cervical cancer treatment with bevacizumab alone or in combination with bevacizumab. In this research, a Markov model was developed to investigate the cost and health risks of treating patients with advanced and metastatic cervical cancer treatment in patients with advanced and metastatic cervical cancer treatment of patients with standard chemotherapy METHODS CONCLUSIONAddition of bevacizumab to the standard chemotherapy has resulted in an increase in the cost of treating advanced and metastatic cervical cancer in India at a minimum of 1-time per capita gross domestic product.
Source link: https://doi.org/10.1200/GO.21.00355
"Introduction: "Despite attempts to encourage all reproductive age women to use cervical cancer screening services, some women do not use them. " Aim: To explore the barriers and facilitating factors for cervical cancer screening beyond a lack of expertise and availability of services. Methods and Methods: This qualitative survey was carried out among tribal women living in the West Bengal, India's Kiranchandra Tea Estate and Atal Tea Estate from July 2018 to February 2019. Screening services were provided in the gardens on garden holidays for two weeks in a row, as part of the Information Education Campaign on cervical cancer and screening was launched, and screening services were provided in the gardens on garden holidays for two weeks in a row. Conclusion: According to the present report, there are several real and perceived barriers to cervical cancer screening among tribal women in tea garden areas. ".
Source link: https://doi.org/10.7860/JCDR/2022/52280.16208
"Cervical cancer is one of the most common gynecologic disorders worldwide, and it is related to human papillomavirus infection, especially high-risk type HPV16 and HPV18. " We discovered a collection of aberrantly expressed key genes from The Cancer Genome Atlas database in this research, which may be used to determine patients with cervical squamous cell carcinoma survival rates. According to the algorithm of weighted gene co-expression network analysis, 1,606 differentially expressed genes were found in both normal and cancerous samples, while 1,964 DEGs were downregulated. Our study, therefore, provides a novel way to establish multiple biomarkers for cervical cancer prognosis and anticancer drug targets. ".
Source link: https://doi.org/10.3389/fcimb.2022.926348
"Cervical cancer is the fourth most common cancer among women worldwide," says the author. After the application of acetic acid, papanicolaou test, human papillomavirus test, and histopathology examination, cervical cancer is tested using visual inspection. Methods: 4005 colposcopy images and 915 histopathology photographs were collected from various local health clinics and online public databases, with the intention of this study being to develop an integrated and robust system for automatic cervix type and cervical cancer classification using deep learning methods. The extracted cervix photos were then submitted to the EffecientNetb0 model for cervix type classification.
A ranging from a regionally advanced cervical cancer diagnosis to a complete lymph node dissection, to a complete lymph node occlusion. In a first case-cohort of cervical cancer patients with suspected pelvic lymph nodes on imaging, a retrospective series of LACC patients with/without suspicious pelvic lymph nodes is reported. In both cases, lower para-aortic SLNs were present, and in 9 out of ten cases, upper-aortic SLNs were found in 9 out of ten cases. The mean body mass index was 23. 96, according to the cervical cancer survivors' mean age of 49. 8 years. The mean numbers of primary pelvic SLNs and secondary lower and upper para-aortic SLNs were 3. 10, 2. 90, and 2. 30, respectively. To determine the sensitivity and negative predictive value of this new surgical procedure and whether the lower oortic SLNs under the inferior mesenteric artery are representative of the whole region's aortic zone, large prospective observational studies are required in LACC and/or those with suspicious pelvic LNs but apparent normal para-aortic LNs on imaging" is required.
Source link: https://doi.org/10.3389/fsurg.2022.905083
The majority of therapeutic failures in cervical cancer patients who undergo radical radiotherapy are due to "ObjectiveInsensitivity to radiotherapy. " In CC, the atypical protein kinase C iota gene PRKCI shows tumor-specific copy number amplification. paraphrasedoutput:MethodsMethods investigated how PRKCI decreases radiosensitivity in CC and assessed the interaction between PRKCI and the Hedgehog/GLI1 pathway in the current study. Methods We investigated how PRKCI decreases radiosensitivity in CC and found the connection between PRKCI and the Hedgehog/GLI1 pathway, cell cycle, apoptosis assays, and xenograft models investigated how PRKCI in chemi Purdue's chromatin inhibiting PKCu03b9 gene regulater, auranofin, was discovered in vivo and in vivo. Results:Higher PRKCI expression was responsible for decreased survival in CC cells, according to researchers. This molecule modulates radiosensitivity by modulating GLI1 relocalization and phosphorylation in CC via the Hh/GLI1 pathway. ".
Source link: https://doi.org/10.3389/fonc.2022.887139
"The oncological outcomes of locally advanced cervical cancer patients following chemotherapy are poor and heterogeneous. " The aim of this research, based on the study's findings, was to determine the role of the hemoglobin-albumin-platelet inflammatory index in predicting LACC patients' oncological outcomes. Patients and Methods: The goal of this study was to determine whether or not predicting oncological outcomes in LACC patients. Patients with a HALP score of 2264 22. 2 tended to have lower age, reduced comorbidity risk, lower body mass index, higher stage, larger tumor size, and a greater chance of receiving radiation alone than concurrent chemotherapy were all found in patients. Conclusion: A lower HALP score was an independent predictor of poorer oncological outcomes, a validating factor for poorer oncological outcomes, according to both groups.
"Objectives Cervical cancer is one of the most common diseases caused by persistent HPV infections that affects women worldwide, particularly in developing countries. " CC susceptibility has been shown to be influenced by the genetic basis of host immune response, especially cytokine function. IL-10 gene polymorphism has been associated with numerous tumors, according to several cancers, but the CC findings were inconclusive. Results Women with AG and AG+GG genotypes of IL-1082A/G increased risk of CC [OR, 2. 35, p = 0. 005] compared to controls [OR, 0. 05, p = 0. 0005] compared to controls. Compare to controls, women with a g allele of -1082A/G polymorphism were attributed to CC susceptibility [OR, 1. 39, p = 0. 036]. IL-10 serum concentrations were significantly higher in patients compared to controls. ".
Source link: https://doi.org/10.1055/s-0042-1743262
"We investigated the prevalence of secondary cancers in patients treated with CIRT for cervical cancer patients. " We also investigated the prevalence of secondary cancers in patients receiving standard radiotherapy throughout the same period. Methods This retrospective review included patients with cervical cancer who underwent curative RT at our hospital. After RT were classified as secondary cancers, all cancers were found for the first time. To determine the risk of secondary cancers among cervical cancer survivors relative to the general population, standard incidence ratios were calculated. 1052. 4 in the CIRT group and 2481. 5 in the photon RT group were the number of people u2010years during the observation period, with 1051. 4 in the CIRT group and 2481. 5 in the photon RT group. In the CIRT group, 9. 5% and 9. 4% in the photon RT group, respectively, within the ten-year cumulative incidence of all secondary cancers. Conclusions "after CIRT for cervical cancer, the incidence of secondary cancers was similar to that following photon RT. ".
Source link: https://doi.org/10.1002/cam4.4622
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