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Cell Cortex - Europe PMC

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Last Updated: 10 January 2023

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Thalamocortical control of cell-type specificity drives a circuit for processing whisker-related information in mouse barrel cortex

We investigated this in mouse somatosensory cortex, where spiny stellate neurons and pyramidal neurons play distinct roles in processing whisker-evoked signals. These neurons' ability in processing distinct whisker signals within functional cortical columns and as a key player in the development of specific whisker-related circuits in the cortex was a critical role for specific whisker circuits.

Source link: https://europepmc.org/article/PPR/PPR593038


PTEN regulates actin filaments to shape cell cortex architecture

PTEN is a tumor suppressor protein that plays a role in cell homeostasis and genomic stability. Here we discuss a possible association between PTEN and actin in regulating cell morphology. Moesin, an actin-binding ERM protein involved in membrane morphology, is also present in the phosphorylated Moe form and cell cortex dislocation of pMoe. Moreover, F-actin at the membrane and cell frequency in cells with round shape can be reduced by inhibition of actin polymerization. PTEN can control cortical actin polymerization to preserve cell morphology and membrane dynamics by monitoring cell morphology and membrane dynamics, according to these results. PTEN can be controlled by cortical actin polymerization to maintain cellular morphology and membrane dynamics.

Source link: https://europepmc.org/article/PPR/PPR591904


A single-cell transcriptomic atlas characterizes cell types and their molecular features in yak ovarian cortex.

On the Qinghai-Tibetan Plateau, the only bovid animal that can withstand the harsh climatic conditions. Here, single-cell RNA sequencing was used to determine the molecular signature of various cell types in the yak ovarian cortex. Endothelial cells, nature kill cells, stromal cells, epithelial cells, epithelial cells, epithelial cells, and granulosa cells were among the many genes from the various cell types and their functional enrichment analysis, which included endothelial cells, stromal cells, epithelial cells, epithelial cells, epithelial cells, epithelial cells, and granulosa cells. By immunostaining in the yak ovarian cortex, manufacturer genes for oocytes were identified as maker genes for oocytes. The cellular atlas provides insight into female reproductive biology by cellular communications in the yak, which leads to the cellular molecular atlas.

Source link: https://europepmc.org/article/MED/36527406


Large-scale unsupervised discovery of excitatory morphological cell types in mouse visual cortex

Neurons in the neocortex exhibit extraordinary morphological diversity, which is essential for properly wiring neural pathways and giving neurons their functional properties. It's unclear if the extent to which excitatory neurons develops a continuum or is built from distinct clusters of cell types remains unknown. U201d, a low-dimensional morphological code u201d describing more than 30,000 excitatory neurons in mouse visual areas V1, AL, and RL that were reconstructed from a millimeter-scale serial-section electron microscopy volume, according to this study. We took a data-driven approach using graph-based machine learning techniques to produce a low-dimensional morphological morphology code u201d. Atufted neurons were most prominent in layer 4 of the primary visual cortex, although tufted neurons were more prevalent in higher visual regions. We found layer 4 neurons in V1 on the border to layer 5 in V1 on the fourth - layer, which showed a tendency toward avoiding deeper layers with their dendrites.

Source link: https://europepmc.org/article/PPR/PPR588444


Subarachnoid hemorrhage triggers neuroinflammation of the entire cerebral cortex, leading to neuronal cell death.

Although neuroinflammation has been shown to be a significant prognosis factor for EBI, the extent of its thickness in the cerebral cortex remains unclear, although neuroinflammation has been reported to be a common prognosis factor of EBI. We investigated neuroinflammation and neuronal cell death in the cortex distal to the hematoma injection site, from anterior to posterior region 24 h after SAH injury in sections of the mouse cerebrum. Neuroinflammation caused by SAH caused migration of activated microglia from the anterior to the posterior part of the cerebrum, and neuronal cell death increased in correlation with neuroinflammation. Given that the cerebral cortex is involved in long-term memory and mobility, reducing neuroinflammation in both layers of the cerebral cortex can improve patient prognosis in patients with SAH.

Source link: https://europepmc.org/article/MED/36514181


A cell atlas of human adrenal cortex development and disease

The adrenal glands synthesize and release essential steroid hormones such as cortisol and aldosterone, but human adrenal gland development are not fully understood. Steroidogenic pathways favor androgen synthesis in the central fetal zone, but the ability to synthesize cortisol and aldosterone increases with time. Potential ligand-receptor interactions between mesenchyme and adrenal cortex were observed. These findings reveal novel aspects of human adrenal development, including adrenal gland formation, steroid dysfunction, and neonatal stress, among other factors.

Source link: https://europepmc.org/article/PPR/PPR584182

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions