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Objects: Smoking is the most common cause of oral cavity squamous cell carcinoma in nonsmokers, but the etiology of OC-SCC in nonsmokers is uncertain. With OC-SCC, we were aiming for a characterization and functional potential of oral metagenome in nonsmokers. Methods: We did a case-control study using 42 OC-SCC samples and 45 control nonsmokers. MSS was based on DNA extracted from mouthwash samples. Conclusions: There was no significant difference in age, sex, race, or alcohol consumption between OC-SCC and control patients, but there was no significant difference in terms of sex, race, or alcohol consumption between OC-SCC and control patients. Overrepresentation of nucleotides and essential amino acids in controls, according to a review by a bacterial pathway investigator showed overrepresentation in OC-SCC of pathways related to metabolism of flavin, biotin, thiamin, sugars, fatty acids, peptidoglycans, and tRNA, as well as overrepresentation of nucleotide and essential amino acids in controls. In nonsmoker patients with OC-SCC, the oral microbiome is significantly different from that of nonsmoker control patients in taxonomic compositions and functional potentials.
Source link: https://doi.org/10.3390/cancers14246096
Patients with squamous cell carcinoma have notably reduced survival after the formation of distant metastases. SCCs have a long and dynamic effect on their metastatic capacity. The extracellular matrix provides a consistent yet flexible pattern on the metastatic capacity of SCCs. Despite evidence that these characteristics vary by tumor type, ECM alterations in certain cancers have been broadly applied to most metastatic diseases. We'll only discuss how laminins influence the SCC metastatic process. Enhanced laminin protein deposition occurs at the invasive edge of SCC tumors, which is correlated with increased prevalence of laminin-binding integrins, poorer prognosis, and lymphatic dissemination. Although these results are significant, there are still many gaps in knowledge of the emergence of a premetastatic niche, the process of intra- and extravasation, and the ECM's contributions to SCC metastatic cell dormancy. SCC metastasis is a common disease that has characterized both quality of life and patient survival.
Source link: https://doi.org/10.1002/mc.23417
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