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Cell Carcinoma - Europe PMC

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Last Updated: 10 January 2023

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Utilization of a nanostructured lipid carrier encapsulating pitavastatin- Pinus densiflora oil for enhancing cytotoxicity against the gingival carcinoma HGF-1 cell line.

The most common epithelial tumor of the oral cavity is Oral squamous cell carcinoma. This research sought to create nanostructured lipid carriers containing PV and Pd oil, as well as their cytotoxicity against human gingival cell lines. The evaluation, TEM data, embezzlement effectiveness, dissolution effectiveness, and the cytotoxic effectiveness of the improved PV-loaded nanostructured lipid carrier drug delivery system were investigated. Among all the formulations tested for the study, the gel containing optimal PV-Pd-NLCs had good dissolution stability and acceptable rheological performance, as well as the highest cytotoxic activity against the HGF-1 cell line. In the treatment of gingival cancer, in vitro cell viability studies, a synergistic result was found between PV and Pd oil. These results showed that the gel containing PV-Pd-NLCs could be helpful in local therapy of gingival cancer.

Source link: https://europepmc.org/article/MED/36510636


Renal cell carcinoma with inferior vena cava thrombus: did we make progress in oncologic outcomes and complications?

Purpose of investigation aims to investigate renal cell carcinoma with inferior vena cava tumor thrombus is one of the most complicated surgical procedures, owing to the high incidences of associated complications and perioperative mortality. Several imaging techniques are emerging that may help with tumor thrombus diagnosis and diagnostic testing. All thrombi levels are safe and effective, while longer-term results for higher-level thrombotics are expected and promising. Summary Summary: neoadjuvant therapies and minimally invasive methods may be able to improve outcomes in patients undergoing surgical resection for RCC with tumor thrombus.

Source link: https://europepmc.org/article/MED/36621845


Renal Cell Carcinoma With Fibromyomatous Stroma: A New Case

Renal tumors, renal cell carcinoma with fibromyomatous stroma was classified as an emerging or provisional entity of renal cell carcinoma in the 2016 World Health Organization's classification of renal tumors, renal cell carcinoma with fibromyomatous stroma. We report a rare occurrence of RCC FMS in a 62-year-old male patient with hypertension, type II diabetes mellitus, and early chronic kidney disease in a 62-year-old male patient with elevated blood pressure. It was laparoscopic right partial nephrectomy that was performed. The diagnosis of RCC FMS has been confirmed by histopathology and immunohistochemistry studies.

Source link: https://europepmc.org/article/MED/PMC9815789


Cost-Effectiveness Analysis of Toripalimab Plus Paclitaxel and Cisplatin as First-Line Treatment for Advanced or Metastatic Esophageal Squamous Cell Carcinoma.

Introduction To patients with advanced or metastatic esophageal cell carcinoma in China, toripalimab plus paclitaxel and cisplatin is highly effective, although the effects on economic burden are uncertain. TTP's cost-effectiveness was determined from the perspective of the Chinese healthcare system, according to the present study. Methods A Markov model was created to assess the cost-effectiveness of TTP therapy for patients with advanced or metastatic ESCC. TTP's total cost was $ 123,646. 43 and gained 1. 10 QALYs, while the paclitaxel and cisplatin chemotherapy group produced 0. 84 QALY at a cost of $ 16,259. 65. With an additional 0. 26 QALY, first-line TTP therapy cost an incremental amount of $ 7,386. 78 per QALY, giving an ICER of $ 28,348. 42/QALY, which was lower than the WTP threshold in China. Conclusions From the perspective of the Chinese healthcare system, TTP was likely more cost-effective than TP chemotherapy.

Source link: https://europepmc.org/article/MED/36622553


Transient loss of consciousness immediately after total pancreatectomy for pancreatic metastases from renal cell carcinoma: a case report.

History Total pancreatectomy is often used for the treatment of various pancreatic diseases. Case study A 77-year-old man who had undergone right nephrectomy for renal cell carcinoma 11 years ago presented with multiple histologically diagnosed pancreatic metastases. The glucose level and pH gradually increased after induction of continuous intravenous insulin infusion and the discontinuation of fentanyl. Conclusion This case illustrates the importance of active monitoring of the glycemic state and pH after TP due to the possibility of deterioration due to TP itself, as well as the lingering effects of anesthesia.

Source link: https://europepmc.org/article/MED/36622508


Transcriptomic Analyses Reveal Three Distinct Molecular Subgroups of Merkel Cell Carcinoma with Differing Prognoses.

Merkel cell carcinoma is a cutaneous neuroendocrine disease with poor prognosis and unknown cell of origin. Epithelial stem cells of the hair follicular epidermis, dermal stem cells, and pro/pre- or pre-B cells of origin are among the hair follicle or interfollicular epidermis' prothelial stem cells, as well as pro/pre- or pre-B cells of origin. We performed RNA sequencing on primary tumor samples from 102 patients and found the top 200 most variable genes. The functions of three gene clusters with notably different expression between samples were investigated by cross-referencing gene lists with online databases. High expression of a gene cluster related to embryonic development and low expression of a gene cluster related to neuroendocrine processes distinguished Merkel cell polyomavirus-negative tumors from MCPyV-positive tumors. We believe that epidermal and a non-epidermal origin for MCPyV-positive MCC could be both epidermal and a non-epidermal origin for MCPyV-positive MCC.

Source link: https://europepmc.org/article/MED/36620996


Real-life experience of patients with sarcomatoid renal cell carcinoma: a multicenter retrospective study.

Sarcomatoid renal cell carcinoma is a rare occurrence of renal cell carcinoma in the United States and is associated with a poor prognosis. Patients from oncology centers in Turkey were analyzed for their health. The sRCC's demographic and clinical characteristics, diagnosis, and survival results of 148 patients were investigated. At the time of diagnosis, the majority of patients were in the intermediate Memorial Sloan-Kettering Cancer Center risk group and were stage 4 at the time of diagnosis. Poor prognosis affecting OS were largely responsible for poor prognosis affecting OS, according to a multivariate review, high MSKCC scores, sarcomatoid differentiation rates > 50%, having stage 4 disease, and having lung metastasis at the time of diagnosis. Patients who received tyrosine kinase inhibitor as the first or second-line therapies were not identified as patients. In addition, there is no difference between TKI and immunotherapy as the second-line therapy. In summary, sRCC is a rare RCC variant with poor prognosis and response to therapy.

Source link: https://europepmc.org/article/MED/36620878


Characterization of Cornulin as a Molecular Biomarker for the Progression of Oral Squamous Cell Carcinoma

Objectives This research aims to investigate Cornulin expression at the cellular level in several cell lines representative of oral squamous cell carcinoma genesis steps, a common form of head and neck cancer. Study design Cornulin expression levels were determined using standardized cell lysates from four separate cell lines representing successive steps of OSCC progress. Cornulin is significantly reduced by 3. 4 folds in DOK cells, by 23. 7 folds in SCC25 cells, and by 5. 2 folds in Detroit 562 cells relative to normal gingival keratinocytes, according to quantitative analysis. Cornulin expression in the metastatic cell line Detroit 562 versus the locally invasive cell line SCC25 indicates a potential connection between these two phenotypes' biological function and unique characteristics.

Source link: https://europepmc.org/article/MED/PMC9812004


Merkel cell carcinoma: a forty-year experience at the Peter MacCallum Cancer Centre.

Background Merkel cell carcinoma is a rare yet highly infectious neuroendocrine skin disease, with Australia having the world's largest reported prevalence. Methods This was a retrospective review that was conducted by looking at existing medical records of MCC patients presenting to the Peter MacCallum Cancer Centre between 1980 and 2018. According to estimates, 5-year OS and DFS were 46 percent and 34 percent respectively. On multivariable results, older age of diagnosis and larger primary tumor diameter were correlated with reduced OS. In patients treated with post-operative radiotherapy, positive or negative histopathological margin status was not linked to OS or DFS differences. Conclusions: About a third of patients in our survey developed locoregional recurrence, distal recurrence, or both, and no change has occurred in the last four decades, according to the researchers. There is no difference in OS or DFS with positive surgical margins when treated with adjuvant radiotherapy.

Source link: https://europepmc.org/article/MED/36611133


VHL Mutation Drives Human Clear Cell Renal Cell Carcinoma Progression Through PI3K/AKT-Dependent Cholesteryl Ester Accumulation

Cholesteryl ester accumulation is an important sign of clear cell renal cell carcinoma differentiation, but its biological mechanisms and pathological significance remain elusive. We found aberrant CE accumulation in human ccRCC tissues but not in normal kidney tissues, which was aided by label-free Raman spectromicroscopy. Primary cancer cells were isolated from human tissues to maintain the CE-rich phenotype in order to solve this problem. The mutation of tumor suppressor VHL, as well as subsequent tightening of the HIF/PI3K/AKT/SREBP pathway was the cause of CE accumulation in ccRCC, according to our findings.

Source link: https://europepmc.org/article/PPR/PPR593400

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions