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Cell Carcinoma - Crossref

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Last Updated: 10 January 2023

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Upregulation of the c-MYC oncogene and adjacent long noncoding RNAs PVT1 and CCAT1 in esophageal squamous cell carcinoma

The esophagus carcinoma of the squamous cell carcinoma is a fatal disease with poor prognosis and a high incidence of lymphatic metastases. In addition, it is also unknown if these lncRNAs are related to the clinicopathological features of patients with ESCC. Methods This study was based on biopsy from the Imam Khomeini Cancer Institute's tumor bank in Tehran, Iran, to collect 40 ESCC tumor samples and their normal margin counterparts. Bioinformatics analysis was performed with the Graphpad prism version 8, which was used for bioinformatics analyses. Patients with elevated PVT1 expression exhibited higher risk of advanced stage and lymph node metastasis, but more widespread CCAT1 expression was only related to advanced stage and lymph node metastasis, but not linked to lymph node metastasis, according to study authors. According to a bioinformatics analysis, PVT1, CCAT1, and c-MYC were found to interact with 23 miRNAs with high and medium score classes.

Source link: https://doi.org/10.1186/s12885-022-10464-z


Design and Synthesis of New Quinoxaline Derivatives as Potential Histone Deacetylase Inhibitors Targeting Hepatocellular Carcinoma: In Silico, In Vitro, and SAR Studies

The most popular ten candidates were further tested for their effect on Bax's gene expression levels as an anti-apoptotic marker and Bcl-2 as an anti-apoptotic one. As determined by cell cycle analysis, HepG-2 achieved a more significant decline in cell growth in HepG-2's growth during cell division expansion in both G0/G1 and S phases, growing cells by 1. 23-fold and 1. 18-fold, respectively, relative to that of the control. Both early and late phases of the AnxV-FITC apoptotic HepG-2 cell percentage in both early and late phases increased by 9. 98-fold and 10. 81-fold, respectively, relative to the control.

Source link: https://doi.org/10.3389/fchem.2021.725135


Impact of adjuvant chemotherapy for radically resected esophageal squamous cell carcinoma: A propensity score matching analysis

Abstract: The aim of this research was to determine the effects of adjuvant chemotherapy in patients of squamous cell carcinoma that had been surgically removed. Patients with esophageal cancer who underwent esophagectomy at our hospital from 2010 to 2019 were retrospectively reviewed. In this analysis, only patients with radically deconstructed ESCC who did not receive neoadjuvant therapy or adjuvant radiotherapy were admitted. Patients with adjuvant chemotherapy had 93. 4%, 66. 9%, and 59. 6%, respectively, compared to 83. 8%, 58. 4%, and 48. 8% for patients with surgical alone. Conclusions: After radical resection, postoperative adjuvant chemotherapy can enhance the OS and DFS of ESCC patients, but it can only work for patients in specific subgroups.

Source link: https://doi.org/10.21203/rs.3.rs-2443266/v1


Construction of a prediction model of cancer-specific survival after ovarian clear cell carcinoma surgery

Purpose: Abstract Purpose The aim of this paper is to develop a nomogram scheme for predicting postoperative cancer-specific survival of patients with ovarian clear cell carcinoma and investigating in detail the risk factors associated with OCCC. Methods The clinical pathological records of 596 OCCC patients were obtained from the Surveillance, Epidemiology, and End Results database from 2010 to 2015. Findings The independent risk factors for CSS in OCCC patients were FIGO stage, race, age, tumor localization, and the log odds of positive lymph nodes. In the preparation group and 0. 742 in the verification group, the c-index of the nomogram for CSS was 0. 786 and 0. 742 in the verification group. Conclusion based on real population results, the development of the CSS prediction model after OCCC surgery has high predictability, can identify postoperative high-risk OCCC patients and can be a valuable aid in the tumor staging process.

Source link: https://doi.org/10.21203/rs.3.rs-2038398/v1


Correlation between immune-related adverse events and long-terms outcome in pembrolizumab-treated patients with unresectable hepatocellular carcinoma: a retrospective study

Abstract Background Although immune checkpoint inhibitors have improved the prognosis of unresectable hepatocellular carcinoma, the condition has also resulted in the rare immune-related adverse events. The relationship between irAE and treatment outcomes in ICIs-treated advanced HCC patients remains unclear. Methods From March 2019 to February 2021, a total of 190 unresectable HCC patients receiving Pepicillin therapy were retrospectively reviewed. The median TTP was 98 days, and the median OS was 376 days. They were 72. 6% and 10. 0% of cases of severe irAEs in the overall population. Patients with hypothyroidism were observed to have a longer lifespan than those without irAE and a longer TTP. Conclusion HCC patients with hypothyroidism demonstrated a positive therapeutic effect, according to a bettertherapeutic result. Hypothyroidism, an immune-related adverse event, could be used as a clinical assessment tool for HCC responses to ICIs.

Source link: https://doi.org/10.21203/rs.3.rs-2222674/v1


Prognostic role of primary tumor metabolic-volumetric parameters of 18F-fluorodeoxyglucose positron emission tomography in tongue squamous cell carcinoma

Aim: It was intended to determine the prognostic value of primary tumor metabolic-volumetric parameters of 18F-Fluorodeoxyglucose positron emission tomography/computed tomography in resectable tongue squamous cell carcinoma. The imaging findings of 44 TSCC patients with resectable tumors who underwent 18F-FDG PET/CT imaging for primary staging before surgery between 2010-2021 were reviewed retrospectively. Patients with higher MTV had lower OS and PFS scores than those with lower MTV. Conclusion: Primary tumor MTV is a primary prognostic factor in resectable TSCC. PET volumetric measurements can be used as a prognostic biomarker to identify patients with poor prognosis.

Source link: https://doi.org/10.32322/jhsm.1220117


Cathepsin S Evokes PAR2-Dependent Pain in Oral Squamous Cell Carcinoma Patients and Preclinical Mouse Models

Oral squamous cell carcinoma pain is more common and severe than pain caused by any other form of cancer. We discovered that cathepsin S was more active in human oral SCC than matched controls, and that in an orthotopic xenograft tongue cancer model than normal tongue. The multiplex immunolocalization of cathepsin S in human oral cancers suggests that carcinoma and macrophages produce cathepsin S in the oral cancer microenvironment. Cathepsin S produced nocience in wild-type mice but not in mice lacking PAR2 in Nav1. 8-positive neurons nor in mice treated with LY3000328 or an endogenous cathepsin S inhibitor. Our results show that cathepsin S is stimulated in oral SCC, and that cathepsin S contributes to cancer pain in neurons through PAR2 on neurons.

Source link: https://doi.org/10.3390/cancers13184697


Progress of MRI Radiomics in Hepatocellular Carcinoma

Hepatocellular carcinoma is the sixth most common cancer in the world and the third leading cause of cancer-related deaths. Radiomics extracts from various types of images to produce models and predict clinical outcomes noninvasively before surgery, making it a useful aid in making personalized treatment decisions preoperatively. The aim of this article was to assess the operational efficiency of radiomics and the study of magnetic resonance imaging radiomics in the diagnosis and treatment of HCC. HCC patients' prognosis, differential diagnosis, histological grade, microvascular invasion status, gene expression status, local and systemic therapeutic responses, and HCC patients' prognosis can be determined by MRI biomarkers. MRI radiomics has a significant use in the diagnosis and treatment of HCC.

Source link: https://doi.org/10.3389/fonc.2021.698373


CircRNA-mTOR Promotes Hepatocellular Carcinoma Progression and Lenvatinib Resistance via PSIP1/c-Myc Axis Nuclear Translocation and Partially through Increasing EGFR Expression

CirRNA-mTOR has been shown to promote hepatocellular carcinoma formation and lenvatinib resistance by improving the stemness of HCC cells in vivo and in vitro experiments. Mechanismically, circRNA-mTOR could influence RNA-binding protein nuclear translocation by specifically binding to it, as well as increasing HCC cell stemness via the PSIP1/c-Myc axis, thereby encouraging HCC and lenvatinib resistance. And, in addition, circRNA-mTOR may help to raise the expression of EGFR in HCC in HCC by increasing the expression of EGFR. This report provides a concrete scientific basis for the targeted drug therapy of HCC and brings forward new insights, new findings, and new approaches in identifying the occurrence and growth of HCC, and it is of umost importance to look for new markers and targets for diagnosis and treatment of HCC.

Source link: https://doi.org/10.21203/rs.3.rs-2437109/v1

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions