Cell Biology - Springer Nature

Modeling the Cell Biology of Prions

Cell lines were created later to investigate the effects of mutations on the prion protein metabolism and, in parallel, the normal synthesis and processing of the cellular prion protein.

Source link: https://doi.org/10.1007/978-3-031-20565-1_14

Lipid Raft Facilitated Receptor Organization and Signaling: A Functional Rheostat in Embryonic Development, Stem Cell Biology and Cancer

Over the past 50 years, Molecular theories of plasma membrane organization and dynamics have been gradually evolving. Several signaling nexuses are present in eukaryotic cells, and several signaling nexuses are inactivated by plasma membrane dynamics. lipid rafts are unusual among other membrane subdomains in terms of functionality. lipid rafts in cellular metabolism and homeostasis are analyzed in this regard, including GPCRs, catalytic receptors, and ionotropic receptors embedded within, as well as multiple signaling pathways. The developmental procedures were developed for patterning of the entire organism, but they differ from fully developed organisms' somatic cell physiology and signaling. We have outlined and reviewed the roles of lipid rafts in embryonic development, cell signaling, and gene expression during embryonic development; from pre-implantation to post-implantation, stem cell and cancer biology; In view of this, we've outlined and discussed the roles of lipid rafts in embryonic development.

Source link: https://doi.org/10.1007/s12015-022-10448-3

Introduction: Impact of Nanotechnology on Plant Cell Biology

This book explores the latest developments in nanotechnology Nanotechnology, emphasizing the relationship between nanoparticles and plants at the cellular level. Nanomaterials' introduction into plant cells, their effect on cell division reactions, and their effect on total crop yield are among the topics. These chapters include information about plant responses to NMs Nanomaterials applications, including morphological, physicochemical, and anatomical variations, as well as their effect on plant growth and productivity. NPs Nanoparticles' absorption and translocation are also discussed as a result of their interaction with the plant's biological chemistry and organelles.

Source link: https://doi.org/10.1007/978-3-031-20878-2_1

Functional Applications of Stable Tau Oligomers in Cell Biology and Electrophysiology Studies

Aggregated tau protein plays a vital role in the pathogenesis of neurodegenerative tauopathies, including Alzheimer's disease. To investigate the mechanistic correlations between oligomer formation and neurodegeneration, tau oligomers complicates vitro functional studies. This technique allows for the flexibility of stabilizing tau oligomers by specifically labelling cysteine residues with fluorescent or colorless maleimide conjugates. We'll explore here how these preformed stable tau oligomers can be used in cell biology and electrophysiological research.

Source link: https://doi.org/10.1007/978-1-0716-2597-2_11

Comparative Genomics for Evolutionary Cell Biology Using AMOEBAE: Understanding the Golgi and Beyond

Taking an evolutionary approach to cell biology can give us valuable new insight into how the cell behaves and how it evolved to do so. It also includes an example dataset that shows that Golgi protein AP4 Epsilon is the sole remaining subunit of the AP4 complex of basidiomycete fungi, with the AP4 Epsilon representing the sole remaining subunit of the AP4 complex in basidiomycete fungi. AMOEBAE can support comparative genomic studies by balancing reproducibility and speed with user input and interpretation. Cell biologists may be encouraged to incorporate an evolutionary perspective into their research by AMOEBAE or similar technologies.

Source link: https://doi.org/10.1007/978-1-0716-2639-9_26

Revelations in Thymic Epithelial Cell Biology and Heterogeneity from Single-Cell RNA Sequencing and Lineage Tracing Methodologies

Thymic epithelial cells contribute to the establishment of a functionally healthy and self-tolerant T-cell lineage. Cortical TECs, which are present in the cortex, are vital for early thymocyte differentiation, including the selection of thymocytes that have functional TCRs. Medullary TECs, based in the medulla, plays a significant role in late thymocyte formation, including the depletion of self-reactive T cells and the selection of regulatory T cells. The transition from embryonic to adult stages of scRNA-Seq's discovery made possible by scRNA-Seq's achievement, which included the discovery of novel mTEC subsets, advances in understanding mTEC promiscuous gene expression, and TEC alterations from embryonic to adult stages.

Source link: https://doi.org/10.1007/978-1-0716-2740-2_2

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