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Cell Adhesion Molecule Expression - Wiley Online Library

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Last Updated: 15 November 2021

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The expression of neural cell adhesion molecule and the microenvironment of pituitary neuroendocrine tumours

The neural cell adhesion molecule has previously been studied in pituitary neuroendocrine tumours, but its function in tumour biology and aggressiveness stays controversial, and its relationship with the tumor microenvironment stays unknown. We aimed to characterise NCAM expression in PitNETs, to associate this with clinico‐pathological functions, and to examine the duty of different microenvironment parts on NCAM expression. There were no substantial NCAM expression distinctions in between PitNETs and normal pituitary, and no difference in between kinds of pituitary tumors. NCAM immunoreactivity was adversely correlated with TAF‐derived fibroblast development element 2, but not with various other TAF‐derived cytokines. Within the PitNET cohort, there were no connections in between NCAM immunoreactivity and immune infiltrates or proportions, although, within NF‐PitNETs, NCAM expression was greater in tumors with more FOXP3+ cells.

Source link: https://onlinelibrary.wiley.com/doi/10.1111/jne.13052

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions