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Endometrioid endometrial adenocarcinomas are the most typical histological variant of deadly tumors in the uterine tooth cavity. To name a few adhesion particles, considerable interest has recently been paid to the molecules of cell adhesion of carcino-embryonic antigen 1. It has been shown that endometrial tissue shows various expression of MCA-REA1 and E-cadherin receptors in the regular state and in endometrioid adenocarcinomas. On the other hand, the endometrioid endometrial carcinoma tissues showed the obvious heterogeneous location of MCA-REA1 in tumor cells. During cancer dedifferentiation, the intensity of E-cadherin expression reduced, which was come with by an increase in nuclear polymorphism of cancer cells and focal separation of cells from the overall growth mass. The variability of the expression patterns of MCA-REA1 and E-cadherin in the dedifferentiation of endometrioid adenocarcinoma might be a sign of neoplastic change and progression of the malignant process.
Source link: https://doi.org/10.26693/jmbs06.05.089
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