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The introduction of TRPC1, -4, and -5 homo- or homomers at the plasma membrane and to the influx of Ca2+ into cultured cortical neurons and CHO cells expressing NCAM, PSA, and TRPC1, -4, and -5, as well as NCAM, FP1 and -5. The influx was not detected in NCAM-deficient cortical neurons nor in TRPC1/4- or TRPC1/5-expressing CHO cells that express NCAM but not PSA. Our results show that the interactions of NCAM, TRPC1, -4, and -5 contributes to the NCAM-stimulated and PSA-dependent Ca2+ entry into neurons, directly effecting key neural pathways.
Source link: https://europepmc.org/article/MED/36077460
Sixty patients with plaque-type psoriasis were enrolled in the study. tau protein, neuronal cell adhesion molecule, and neprilysin, three ND biomarkers who have not been extensively investigated in psoriasis, were determined before and after 12 weeks of treatment with acitretin or methotrexate. Patients' mortality and NEP values were significantly lower than those who did not, although MAPT was much higher. The number of NrCAM and NEP significantly increased during the therapy, and MAPT decreased. Psoriasis severity and duration do not appear to have an effect on the risk of neurodegenerative disease.
Source link: https://europepmc.org/article/MED/36078974
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