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Cell Adhesion Molecule - Europe PMC

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Last Updated: 10 January 2023

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Lack of the Ig cell adhesion molecule BT-IgSF (IgSF11) induced behavioral changes in the open maze, water maze and resident intruder test.

Ig superfamily protein, which is both brain- and testis-specific, is a homotypic cell adhesion protein. BT-IgSF controls AMPA receptors in cultured hippocampal neurons' membrane, modulating the connectivity of chandelier cells and coordinating gap junction-mediated astrocyte-astrocyte communication in the nervous system. Although BT-IgSF-deficient mice initially discovered the platform in the water maze, their behavior was disrupted when the platform was relocated, indicating decreased behavioral flexibility. In addition, male BT-IgSF-deficient mice increased aggression toward an attacker. Our findings show that specific behaviors are affected by a lack of BT-IgSF, as well as the contribution of BT-IgSF to network operations.

Source link: https://europepmc.org/article/MED/36607983


Activated Leukocyte Cell Adhesion Molecule (ALCAM), a Potential 'Seed' and 'Soil' Receptor in the Peritoneal Metastasis of Gastrointestinal Cancers.

Activated Leukocyte Cell Adhesion Molecule is a cell-cell adhesion protein that promotes heterotypic and homotypic interactions between cells of the same type and those of various forms. Specifically, we investigated whether ALCAM behaves as both a'seed' receptor in these tumor cells and a'soil' receptor in peritoneal mesothelial cells during cancer metastasis. The ALCAM expression of gastric cancer and pancreatic cancer tissues with or without peritoneal metastasis were compared for their ALCAM levels. Human peritoneal mesothelial cells were also genetically modified to create cell models with different characteristics of ALCAM expression. Patients with peritoneal metastases had higher ALCAM transcripts than those without. Both gastric and pancreatic tumour tissues from patients with peritoneal metastases had higher levels of ALCAM transcripts than those without. Patients with tumors with high ALCAM content had a much shorter peritoneal metastasis free survival than those with low ALCAM levels. The cells were found with reduced communication with both gastric cancer cells and pancreatic cancer cells after the ALCAM knockdown of the mesothelial cell line MET5A. In addition, the ALCAM expression in both human gastric and pancreatic cancer cells was also a determining factor for their adhesiveness to mesothelial cells, a process that was supposed to be responsible for the phosphorylation of the SRC kinase. A soluble ALCAM was discovered to be able to reduce the adhesion between cancer cells and mesothelial cells, mechanistically behaving like a SRC kinase inhibitor. Both gastric and pancreatic cancer patients with ALCAM are a sign of peritoneal metastasis.

Source link: https://europepmc.org/article/MED/36614319


Activated Leukocyte Cell Adhesion Molecule (ALCAM), a Potential ‘Seed’ and ‘Soil’ Receptor in the Peritoneal Metastasis of Gastrointestinal Cancers

Activated Leukocyte Cell Adhesion Molecule is a cell-u2013cell adhesion protein that promotes heterotypic and homotypic interactions between cells of the same species and those of varying types of cells. Specifically, we investigated whether ALCAM serves as both a u2018seedu2019 receptor in these tumour cells and a u2018soilu2019 receptor in peritoneal mesothelial cells during cancer metastasis. The expression of ALCAM in gastric cancer and pancreatic cancer tissues with or without peritoneal metastasis were compared for their levels of ALCAM. The peritoneal mesothelial cells of Human peritoneal mesothelial cells were also genetically modified to create cell models with different characteristics of ALCAM expression. Both gastric and pancreatic tumor tissues from patients with peritoneal metastases had higher ALCAM transcripts than those without. Patients with tumours that had high ALCAM were asymptomatic metastasis free survival in comparison to those with poor ALCAM expression. The cells' interaction with both gastric cancer cells and pancreatic cancer cells was reduced after the cells' knockdown of the mesothelial cell line MET5A by ALCAM. In addition, levels of ALCAM in both human gastric and pancreatic cancer cells were also a determining factor for their adhesion to mesothelial cells, a process that was likely to trigger SRC kinase phosphorylation. A soluble ALCAM was found to be able to reduce the adhesion between cancer cells and mesothelial cells, mechanistically behaving like a SRC kinase inhibitor. During cancer metastasis, it appears that it is not limited to a potential peritoneal u2018soil u2019 receptor of tumour seeding but also a u2019soilu2019 receptor in peritoneal mesothelial cells.

Source link: https://europepmc.org/article/MED/PMC9821744


Mucosal addressin cell adhesion molecule 1 expression reflects mucosal inflammation and subsequent relapse in patients with ulcerative colitis.

Background and aims Mucosal addressin cell adhesion molecule 1 is upregulated in the vascular endothelium of the colonic mucosa in ulcerative colitis. Although the connection between MAdCAM-1 expression and mucosal inflammation has been discussed, no link has been established between the two conditions in UC patients. In this research, we investigated not only the relationship between mucosal MAdCAM-1 expression and mucosal inflammation, but also its connection with subsequent relapse in UC patients with clinical remission. MRNA and protein expression in the relapse group were much higher in the relapse group than in the remission group, suggesting that MAdCAM-1 expression in the mucosa was already elevated in UC patients in clinical remission who later relapsed. Conclusions MAdCAM-1 expression in the granic mucosa of UC patients related to mucosal inflammation and subsequent relapse; it may act as a marker for both relapse and therapeutic success in UC patients.

Source link: https://europepmc.org/article/MED/36511086

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions