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Cell Adhesion Migration - Wiley Online Library

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Last Updated: 21 January 2023

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Treponema pallidum lipoprotein Tp0768 promotes the migration and adhesion of THP‐1 cells to vascular endothelial cells through stress of the endoplasmic reticulum and the NF‐κB/HIF‐1α pathway

A vital role is played by T. pallidum lipoprotein's migration and adhesion reaction. This research was designed to investigate the migration and adhesion effects of T. pallidum lipoprotein Tp0768 and its molecular mechanism. By the PERK and IREu20131 pathways of endoplasmic reticulum stress, Tp0768 promoted the THPu20101 cells migrating and adhering to vascular endothelial cells, according to our findings. Also, the adhesion rate of THPu20101 cells to endothelial cells decreased. Through ER stress and the NF/HIFu20101 pathway, our results showed that T. pallidum lipoprotein Tp0768 promoted migration and adhesion of THPu20101 cells to vascular endothelial cells.

Source link: https://onlinelibrary.wiley.com/doi/10.1111/mmi.15010

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions