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Cell Adhesion - Springer Nature

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Last Updated: 10 September 2022

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Ubiquitous Neural Cell Adhesion Molecule (NCAM): Potential Mechanism and Valorisation in Cancer Pathophysiology, Drug Targeting and Molecular Transductions

Through a number of temporal-spatial laws that gradually change cell adhesion molecules, the neural cell adhesion molecule involved in cell-cell adhesion, undergoes various structural changes. NCAM plays a significant role in neurite growth, brain formation, and etc. The usefulness of NCAM in proliferating tumour cells and metastasis of several human melanomas is demonstrated by many clinical moieties, with the consistent use of the cell surface marker for diagnosis and potential target for several therapeutic moieties. NCAM's increased presence on cell surface has ignited curiosity among pharmaceutical scientists, prompting them to investigate the role of such expressions in various human melanomas and to explore the promising therapeutic approaches that are currently available to target NCAM appositely.

Source link: https://doi.org/10.1007/s12035-022-02954-9


Novel circularRNA circ-0047078 promotes pancreatic ductal adenocarcinoma progression through mircoRNA miR-11181— Chemokine (C-X-C motif) Ligand 12/Melanoma Cell Adhesion Molecule/Regulator of G-protein signaling 16 pathway

Pancreatic ductal carcinoma cancer, which is one of the most common human solid tumors, has a low surgical cure rate. Cir-0047078 was positively connected with the proliferation and migration of cell proliferation and migration, but negatively associated with CFPAC-1 cells' apoptosis. Both caspase-3 and caspase-9 production increased along with decrease invasion and increased apoptosis of CFPAC-1 cells, and no apparent effect on CFPAC-1 cells proliferation was found. caspase-3, caspase-8, and caspase-9 had no effect on proliferation and apoptosis, of course, no apparent improvement had been made on caspase-3, caspase-8, or caspase-9 had been found.

Source link: https://doi.org/10.1007/s11033-022-07723-4


Controlled drug delivery and cell adhesion for bone tissue regeneration by Keplerate polyoxometalate (Mo_132)/metronidazole/PMMA scaffolds

In this regard, scaffold nanofibers were developed using poly, Mo_132 as a Keplerate polyoxometalate and metronidazole. In addition, the addition of Mo_132 and metronidazole enhances the biodegradation rate of resulted scaffolds compared to pure PMMA membranes. The controlled release of metronidazole for 14 days has effectively stopped anaerobic microorganisms from colonizing anaerobic microorganisms. Overall, the findings show that the Mo_132 and metronidazole-loaded PMMA scaffold for guided bone regeneration/guided tissue regeneration.

Source link: https://doi.org/10.1038/s41598-022-18622-w


Effects of hydrophilic polymer-embedded membrane on permeability and cell adhesion during continuous hemofiltration

Filter membrane materials that improve filter membrane material properties can reduce the chance of clotting and prolong the filter life. Methods The NV-PS was tested using continuous hemofiltration in a permeate recycling system, which was divided into two portions for 24 h to compare the NV-PS to a standard polysulfone membrane. After the completion of the CHF experiment, the effect on the membrane's dextran sieving coefficient and the remaining blood clots in the filters were evaluated. Using the NV-PS rather than with the PS, the increase in the transmembrane pressure and the hemofilter's pressure drop were much smaller. The reduction in SC after blood contact was much smaller for the NV-PS for larger molecules. When the NV-PS was used, fewer blood cells were left in the residual blood clots.

Source link: https://doi.org/10.1186/s41100-022-00418-3

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions