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Cell Ablation - Europe PMC

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Last Updated: 10 January 2023

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Ultra-small NIR-Responsive Nanotheranostic Agent for Targeted Photothermal Ablation Induced Damage-Associated Molecular Patterns (DAMPs) from Post-PTT of Tumor Cells Activate Immunogenic Cell Death.

Theranostic nanoparticles is a cost-effective way to bring together diagnosis and therapy into cancer care. The novel NC's photothermal conversion results were determined at 808 nm, where the NC converts light energy to heat energy in a safe manner. Surprisingly, damage-associated molecular patterns from post-PTT of tumor cells induced immunogenic cell death, triggering tumor-specific immune responses in tumor-specific immune responses. The NC is an excellent platform for photoacoustic imaging due to the deserving photothermal results and photo-stability. In a concentration-dependent manner, a superior contrast was obtained for PAI, raising the level of penetration into tissues, thereby improving imaging. The newly produced NC could be used as a "neurotheranostic" designed for medical and image diagnostic agents of cancer biomedical applications, according to this report.

Source link: https://europepmc.org/article/MED/36593797


Thermal ablation versus radiotherapy for inoperable stage III non-small cell lung cancer: a propensity score matching analysis.

Objective: To determine the survival benefits of thermal ablation and radiotherapy in inoperable patients with stage III non-small cell lung cancer, with stage III non-small cell lung cancer. Results The present research included 33,393 inoperable patients with stage III NSCLC, including 106 patients treated with TA and 33,287 patients treated with radiotherapy. There was no significant difference in overall survival or cancer-specific survival between the patients treated with TA and those treated with radiotherapy. Following PSM, the differences in OS and CSS were still not significant between the radiotherapy and TA groups. TA may be a potential therapeutic treatment for inoperable stage III NSCLC.

Source link: https://europepmc.org/article/MED/36535924


Variations in dynamic tumor-associated antigen-specific T cell responses correlate with HCC recurrence after thermal ablation.

Methods We investigated the influence of tumor-associated immunogen -specific immune responses and changes in peripheral blood mononuclear cell phenotype in patients with HCC both before and after tumor ablation. To determine the effectiveness of the immune response in blocking HCC recurrence, the relationship between T cell response and disease outcome was investigated. With a switch from an AFP-specific T cell response to a SMNMS-specific T cell response, which was associated with improved survival, one week after ablation was a week. In addition, an increase in immune status was accompanied by a reduced number of PD1+ and Tim3+ T cells in CD8+ T cells. Ablation elicits a transient antitumor immune response in patients with HCC by altering the T cell function and the expression of immune checkpoint molecules, which are both associated with longer recurrence-free survival of patients with HCC.

Source link: https://europepmc.org/article/MED/36618423

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions