Cell Ablation - Crossref

Trapped ventricle after laser ablation of a subependymal giant cell astrocytoma complicated by intraventricular gadolinium extravasation: case report

Laser ablation of subependymal giant cell astrocytomas in some children with tuberous sclerosis is a promising alternative to maintenance immunotherapy in those children with tuberous sclerosis complex; however, the effect of disease progression and the cause and frequency of potential complications remain largely unclear. The authors explore the case of a 5-year-old boy with TSC who underwent stereotactic laser ablation of a SEGA at the right foramen of Monro on two separate occasions. The patient presented with papilledema and delayed obstructive hydrocephalus as a result of intraventricular adhesions, resulting in a trapped right lateral ventricle nine months later.

Source link: https://doi.org/10.3171/2017.11.peds17518

Integrated proteogenomic characterization and immune response evaluation reveal an imbalanced hepatocellular carcinoma microenvironment induced by incomplete radiofrequency ablation

Abstract Background : After incomplete radiofrequency ablation, researchers struggling to quantify tumor-specific T-cell immune responses capable of mediating dysfunctional hepatocellular carcinoma ecosystems are still facing significant challenges. Methods : Whole blood and tissue samples were obtained from HCC patients who underwent RFA. In HCC patients with early recurrence after RFA, the ability of proteinase-3 to predict overall survival was tested. The number of CD4+ T cells, CD4+CD8+ T cells, and CD4+CD127- Treg cells were significantly elevated, according to a flow cytometry analysis, but the number of CD16+CD56+ natural killer cells was significantly reduced on day 5 following cRFA. Conclusion : This paper gives a comprehensive review of HCC milieus' immune responses and transcriptomic and proteogenomic landscapes, as well as the biological factors involved in tumor formation and iRFA-induced immune responses.

Source link: https://doi.org/10.21203/rs.3.rs-2041668/v1

Clinical value of combined preoperative-postoperative neutrophil-to-lymphocyte ratio in predicting the prognosis of hepatocellular carcinoma after radiofrequency ablation

After radiofrequency ablation in patients with hepatocellular carcinoma, we evaluated the benefits of preoperative and postoperative NLR and PP-NLR in predicting prognosis in patients with hepatocellular carcinoma. Patients with hepatocellular carcinoma who had undergone RFA at Harbin Medical University between January 2018 and June 2019 were retrospectively evaluated for leukocytes, lymphocytes, neutrophils, and NLR before and after RFA. Using univariate and multivariate Cox hazard ratio models, risk factors for early HCC recurrence and risk factors affecting recurrence-free survival were investigated. After RFA, a multivariate review revealed that PP-NLR was an independent risk factor for poor RFS and early recurrence in HCC patients. Patients with elevated preoperative NLR, neutrophils, and alpha-fetogram level; high postoperative NLR, neutrophils, and leukocytes; and multiple tumors may have shorter RFS and a higher risk of early recurrence. P-NLR was more useful in predicting the prognosis than preoperative or postoperative NLR alone.

Source link: https://doi.org/10.21203/rs.3.rs-2013292/v1

Laparoscopic resection vs thermal ablation for 3-5cm hepatocellular carcinoma: A multicenter study based on machine learning

Abstract Background & Background Detailed information based on a summary of Patient with primary hepatocellular carcinoma treated earlier in life. Objectives: After laparoscopic resection and thermal ablation therapy, the aim of the study was to determine the surviving patients with VER. Methods 956 primary HCC patients treated with thermal ablation or laparoscopic resection from 12 centers were included in our study. Both patients and patients with VER in two groups were compared in terms of overall survival and cancer specific survival rate. Following laparoscopic resection, different machine learning techniques were used to develop prediction models of VER occurrences. Patients with VER in two groups have no difference in terms of PSM or CSS, but there is no evidence between OS and CSS before or after PSM. The 3-2 cm primary hepatocellular carcinoma patients with VER after laparoscopic surgery can be healthier if choose thermal ablation instead. The model used in this study can help patients with VER after laparoscopic resection.

Source link: https://doi.org/10.21203/rs.3.rs-2001886/v1

Local Anesthesia vs. General Anesthesia for Percutaneous Microwave Ablation in Hepatocellular Carcinoma, an Efficacy, Safety, and Cost Analysis

Abstract Purpose (abstract): The aim of this paper is to determine the effectiveness, safety, and cost of local anesthesia and general anesthesia modality for percutaneous microwave ablation in hepatocellular carcinoma patients receiving combination therapy for curative therapy purposes. Patients were divided into two cohorts according to the anesthesia modality used during the percutaneous microwave ablation procedure. In the local anesthesia group, there were 105 patients with 128 HCC lesions, while 70 patients with 107 lesions in the general anesthesia group had 105 patients with 107 lesions. After PSM, 51 pairs of patients were matched with 78 lesions in the GA group and 68 lesions in the Los Angeles group. In the GA group, there was more MWA procedure time, medical equipment consumption, and financial strain relative to the LA group than in the LA group. Local anesthesia may be more cost-effective during ablation procedures for HCC patients within Milan limits due to the higher cost of general anesthesia.

Source link: https://doi.org/10.21203/rs.3.rs-1770369/v2

Local Anesthesia vs. General Anesthesia for Percutaneous Microwave Ablation in Hepatocellular Carcinoma, an Efficacy, Safety, and Cost Analysis

Abstract aims : To determine the effectiveness, safety, and cost of local anesthesia and general anesthesia treatment techniques for percutaneous microwave ablation in hepatocellular carcinoma patients undergoing combined therapy for curative therapy purposes. Patients were divided into two cohorts according to the anesthesia modality used during the percutaneous microwave ablation procedure. The local anesthesia group had 105 patients with 128 HCC lesions, and the general anesthesia group had 107 lesions. After PSM, 51 pairs of patients were matched with 78 lesions in the Atlanta area and 68 in the LA group, with 78 lesions in the GA group and 68 lesions in the LA group. In the GA group, there was more MWA procedure time spent, medical equipment use, and financial strain than the LA group relative to the LA group. Local anesthesia may be more flexible during ablation procedures for HCC patients within Milan limits due to the higher cost of general anesthesia.

Source link: https://doi.org/10.21203/rs.3.rs-1770369/v1

Oocyte-specific ablation of N- and O-glycans alters cumulus cell signalling and extracellular matrix composition

For ovulation and fertilisation, Cumulusu2013oocyte complex expansion is crucial, and it is closely related to oocyte quality. At 9 h-post-hCG, DM COCs did not differ from Controls in cumulus size or cell density; however, HA and HC contents, as well as phosphorylated-SMAD1/5/8 were reduced; however, HC and phosphorylated-SMAD1/5/8 were unchanged; however, hemethoda decreased. In addition, no correlations were found between the levels of matrix molecules and the cumulus area in DM or Control samples. We suggest that oocyte-specific ablation of C1galt1 and Mgat1 can influence bone morphogenetic protein 15 synthesis or bioactivity, thus lowering SMAD1/5/8 phosphorylation and HA production.

Source link: https://doi.org/10.1071/rd18209

Dynamic changes in cytokine profiles and their impact on tumour recurrence following thermal ablation in hepatocellular carcinoma

Abstract Background Thermal ablation is widely used as a cutting HCC therapy. We reviewed the effects of thermal ablation on HCC patients'u2019 immune cytokine profiles and identified predictive biomarkers of tumour recurrence herein. HCC patients at baseline were significantly reduced, but MCP-1 was elevated relative to that in healthy controls, according to the authors. IL-6 levels were noticeably elevated at week 1 and plunged at week 4 after ablation, and there were positive correlations between IL-6 levels and ALT and WBC at week 1. Patients with elevated IL-10 levels at baseline and low TNF-u03b1-b1, PDGF-BB, and RANTES at week 4 were also at risk of tumor recurrence, according to TNF-u03b1, PDGF-BB, and RANTES. Conclusions by the authors Thermal ablation aids tumour immune suppression and promotes systemic immune responses by circulating cytokines linked to tumour recurrence.

Source link: https://doi.org/10.21203/rs.3.rs-1998332/v1

RASA2 ablation in T cells boosts antigen sensitivity and long-term function

Abstract : The effectiveness of adoptive T cell therapies for cancer treatment can be limited by suppressive signals from both extrinsic factors and intrinsic inhibitory checkpoints 1,2. These screens joined on RASA2, a RAS GTPase-activating protein that we can recognize as a signalling checkpoint in human T cell transplantation that can be reduced on acute T cell receptor stimulation and can rise with chronic antigen exposure. RASA2-deficient T cells show enhanced activation, cytokine production, and metabolic activity in vitro, in comparison to control cells, and show a significant advantage in persistent cancer cell killing. In a mouse model of leukaemia, RASA2-knockout CAR T cells had a competitive fitness advantage over control cells in the bone marrow. In mice xenografted with either liquid or solid tumours, RASA2 inhibition in multiple preclinical models of T cell receptor and CAR T cell therapy prolonged survival in mice xenografted with either liquid or solid tumours.

Source link: https://doi.org/10.1038/s41586-022-05126-w

Radiofrequency Ablation versus Transarterial Chemoembolization for Hepatocellular Carcinoma within Milan Criteria: Prognostic Role of Tumor Burden Score

A Tumor burden score, determined by the volume and number of tumor nodules, was recently developed to assess the tumor burden in hepatocellular carcinoma. Within the Milan criteria for radiofrequency ablation or transarterial chemoembolization, we wanted to determine the prognostic impact of TBS on HCC patients. In univariate survival study, the RFA group had higher long-term survival than the TACE group in patients within the Milan criteria. Conclusions: TBS is a useful diagnostic tool for HCC patients within the Milan guidelines.

Source link: https://doi.org/10.3390/cancers14174207

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