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Laser ablation of subependymal giant cell astrocytomas in several children with tuberous sclerosis complex may be a safe alternative to maintenance immunotherapy; however, the effect of disease progression and the occurrence and frequency of potential complications remain largely unknown. Two separate times, the authors explore the case of a 5-year-old boy with TSC who underwent stereotactic laser ablation of a SEGA at the right foramen of Monro on two separate occasions. The patient presented with papilledema and delayed obstructive hydrocephalus secondary to intraventricular adhesions, resulting in a trapped right lateral ventricle nine months later.
Source link: https://doi.org/10.3171/2017.11.peds17518
Abstract The treatment of glioblastoma multiforme is particularly difficult due to a lack of techniques to selectively target diffuse infiltrative cells and therapy-resistant glioma stem cell populations. We can't wait for targeted ablation based on nuclear size, although we did show killing of both normal and malignant cells using pulsed electric fields to treat spontaneous canine GBM. Cell death from PEFs can be prevented by the nuclear envelope electric potential disruption, according to experts.
Source link: https://doi.org/10.1038/srep17157
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