Cell 7 - Wiley Online Library

Green synthesized nickel doped cobalt ferrite nanoparticles exhibit antibacterial activity and induce reactive oxygen species mediated apoptosis in MCF‐7 breast cancer cells through inhibition of PI3K/Akt/mTOR pathway

This research was conducted in the hopes of synthesizing the nickel doped cobalt ferrite nanoparticles and determining its anticancer activity on breast cancer MCF/u20107 cells. The various Ni doped CFO nanoparticle sizes were synthesized using Coriandrum sativum extracts by precipitation method. The Niu2010CFO nanoparticles, which were 0. 8% at the end of the analysis, showed better magnetic stability and antioxidant activity than other Niu2010CFO nanoparticles. In addition, administration of 0. 8% Niu2010CFO nanoparticles reduced the Bclu20102 expression while triggering the expression of p53, Bax, and cleaved caspase 3, 8, 8 and 9 protein expression.

Source link: https://onlinelibrary.wiley.com/doi/10.1002/tox.23644

Androgen receptor splicing variant 7 (ARv7) promotes DNA damage response in prostate cancer cells

Androgen deprivation therapy in the treatment of patients with locally advanced prostate cancer significantly improves radiotherapy's success by weakening the DNA damage response pathway. Here, we showed that AR splicing version 7, the most common ARvs, greatly increases the DDR of PCa cells under severe DNA damage independent of their parent's family's. Moreover, the presence of ARv7 also jeopardizes AR antagonists' synergistic interaction with the poly ADPu2010ribose polymerase inhibitor, which has also been suggested as a promising future treatment technique for metastatic castration resistant prostate cancer. Our findings show that consistently robust ARv7 not only contributes to radioresistance after ADT, but also acts as a potential predictive biomarker for determining the efficacy of novel PARP inhibitor-u2010 based therapy in PCa.

Source link: https://onlinelibrary.wiley.com/doi/10.1096/fj.202200190R

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