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Cell 16 - Crossref

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Last Updated: 10 June 2022

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Tobacco Smoking and Cutaneous Squamous Cell Carcinoma: A 16-Year Longitudinal Population-Based Study

The results from previous clinical and case-u2013control studies are inconsistent, with tobacco smoking commonly recommended as a risk factor for cutaneous squamous cell carcinoma. In a population-based survey, we therefore sought to prospectively investigate the role of nicotine smoking in the formation of SCC of the skin. Over a 16-year period, 1992 to 2007, thorough prospective data on sun exposure, smoking, and skin cancer incidence was collected. Conclusions: Cigarette smoking did not raise the risk of SCC of the skin in this Australian follow-up report. Impact: These prospective adjusted results show that cutaneous SCC should not be on the list of tobacco-related cancers, according to these updated reports.

Source link: https://doi.org/10.1158/1055-9965.epi-11-0150


Relationship between Epidermal Growth Factor Receptor Status, p16INK4A, and Outcome in Head and Neck Squamous Cell Carcinoma

"Abstract Background: Human papilloma virus infection is a common prognostic biomarker for head and neck squamous cell carcinoma". This research investigated the connection between HPV status, EGFR gene copy number, EGFR protein expression, and clinical outcomes in HNSCC patients treated with chemoradiation. In 212 patients, HPV status was established by using p16INK4A immunohistochemistry, EGFR gene copy number was determined with FISH, and EGFR protein expression by IHC. EGFR FISH was positive in 41 of 204 patients and was negatively related to failure-free survival and overall longevity. Patients with p16-positive oropharyngeal cancer had dramatic rises in FFS and OS. Only 2 of 126 oropharyngeal cancer patients were found to be p16+/EGFR FISH+. Although p16INK4A and EGFR FISH are both predictive of outcome in univariate studies, only p16INK4A is independently predictive. IMPACT's Impact: Knowing of HPV and EGFR status can have a major effect on treatment choices and prognosis in HNSCC. ".

Source link: https://doi.org/10.1158/1055-9965.epi-10-1262


Human Papillomavirus-16 Modifies the Association between Fruit Consumption and Head and Neck Squamous Cell Carcinoma

"HPV-positive cancers have distinct disease cofactors and improved survival after treatment. " Fruit intake with HNSCC is disputed by inconsistent evidence. We investigated whether the relationship between fruit intake and HNSCC risk was enhanced by HPV-16 exposure as HPV-related disease is clinically distinct. We looked at 270 cases and 493 controls with fruit intake reports and suspected HPV-16 antibody status in addition to known HPV-16 antibody status. With rising citrus fruit intake [odds ratio tertile 2, 0. 60; 95% CI, 0. 35-0. 95] and specifically increasing citrus fruit intake, the seronegative individuals had a significant risk of HNSCC, gender, origin, nicotine, carbon, total energy intake, body mass index, and education, leading to a significant decrease in HNSCC risk, with an increasing risk of HNSCC. [odds ratio tertile 2, 0. 60; 95% CI, 0. 60; Fruit intake was associated with a reduced HNSCC risk among HPV-16-seronegative individuals, but among the HPV-16-seropositive individuals, it was highly significant.

Source link: https://doi.org/10.1158/1055-9965.epi-08-0560

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions