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Cell 16 - Crossref

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Last Updated: 10 January 2023

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Nerolidol, bioactive compound suppress growth of HCT-116 colorectal cancer cells through cell cycle arrest and induction of apoptosis

Abstract Background: Colon cancer is the most common disease worldwide, and it accounts for the most cancer-related deaths in both men and women. HCT-116 cells' viability and cytotoxic mechanisms were investigated by the current research in the colon cancer HCT-116 cells. Methodology of the MTT cell viability assay was conducted to determine the effect of nerolidol at various doses on the HCT-116 cell viability. In the HCT-116 cells, flow cytometry was used to investigate the effect of nerolidol on cell cycle arrest. Conclusions MTT assay findings revealed that nerolidol in different doses significantly reduced the HCT-116 cell viability in the MCT-116 cell viability at an IC50 rate of 25 %u00b5M. The HCT-116 cells' ROS level was also raised after the treatment with nerolidol. Conclusions in HCT-116 cells nerolidol has been shown to hinder cell cycle, increase ROS accumulation, and cause apoptosis.

Source link: https://doi.org/10.21203/rs.3.rs-2430794/v1

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions