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Cell (Play) - MedlinePlus Genetics

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Last Updated: 10 September 2022

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Chronic granulomatous disease

Individuals with chronic granulomatous disease may have recurring bacterial and fungal infections. People with this condition may also have spots of inflammation in several tissues that can cause damage to those organs. Chronic granulomatous disease is common in childhood, but some people don't show symptoms until later in life. At least one severe bacterial or fungal infection is reported every 3 to 4 years for people with chronic granulomatous disease. Individuals with persistent granulomatous disease may experience mulch pneumonitis, which causes fever and shortness of breath after exposure to decaying organic materials such as mulch, hay, or dead leaves. People with persistent granulomatous disease and the numerous fungi involved in their decomposition may suffer fungal infections in their lungs. The skin, liver, and lymph nodes are other common areas of infection in people with chronic granulomatous disease. In people with persistent granulomatous disease, inflammation can occur in a variety of areas of the body. The stomach, colon, and rectum are among the more common areas of inflammation in people with chronic granulomatous disease, as well as the throat, and skin. Inflammation in the stomach can prevent food from traveling through to the intestines, resulting in an inability to digest food. Rarely, people with chronic granulomatous disease have autoimmune disorders that arise when the immune system malfunctions and attacks the body's own tissues and organs.

Source link: https://medlineplus.gov/genetics/condition/chronic-granulomatous-disease


Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome

Multiple autoimmune disorders in the affected individuals are characterized by the onset of multiple autoimmune disorders. Although IPEX syndrome can affect many areas of the body, autoimmune disorders affecting the intestines, skin, and hormone-producing glands are the most common. In early childhood, IPEX syndrome can be life-threatening. Almost all people with IPEX syndrome have autoimmune enteropathy, a disease of the intestines. Autoimmune enteropathy occurs when certain cells in the intestines are destroyed by a person's immune system, resulting in autoimmune enteropathy. People with IPEX syndrome often suffer skin inflammation, known as dermatitis. In IPEX syndrome, other skin disorders that cause similar symptoms are also present. Polyendocrinopathy is used in IPEX syndrome because people can have multiple disorders of the endocrine glands. Type 1 diabetes mellitus is an autoimmune disease affecting the pancreas that is the most common endocrine disorder in people with IPEX syndrome. Autoimmune thyroid disease may also occur in people with IPEX syndrome. Hormone production is present in the thyroid gland, which is a butterfly-shaped organ in the lower neck. Individuals with IPEX syndrome have a variety of autoimmune disorders in comparison to those that involve the intestines, skin, and endocrine glands. Autoimmune blood disorders are common; about half of those affected people have low red blood cells, platelets, or certain white blood cells because these cells are attacked by the immune system. IPEX syndrome affects the liver and kidneys in some people.

Source link: https://medlineplus.gov/genetics/condition/immune-dysregulation-polyendocrinopathy-enteropathy-x-linked-syndrome

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions