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Cell (Play) - Europe PMC

Summarized by Plex Scholar
Last Updated: 10 January 2023

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Diminished schwann cell repair responses play a role in delayed diabetes-associated wound healing.

Diabetes mellitus is the most common metabolic disorder related to impaired wound repair in patients with delayed wound healing. Schwann cells, the peripheral nervous system's glia, have been shown to speed up normal skin wound healing. However, the roles of SCs in diabetic wound healing are not fully understood. In addition, in vitro experiments were carried out using rodent SC and murine fibroblast cell lines to see the effects of elevated glucose conditions on SC de-differentiation of SCs and the paracrine effects of SCs on myofibroblast formation. We found that wound healing was postponed and SCs struggled to implement a repair service after diabetic mice's skin wound injury. These findings show that delayed wound healing in diabetes is in part due to a reduced SC repair response and attenuated myofibroblast formation.

Source link: https://europepmc.org/article/MED/36620211

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions

* Please keep in mind that all text is summarized by machine, we do not bear any responsibility, and you should always check original source before taking any actions